Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of eNOS genotype

Wu, Szu-Yun; Mayneris‐Perxachs, Jordi; Lovegrove, Julie A.; Todd, Susan; Yaqoob, Parveen

doi:10.3945/ajcn.114.088880

Cited by 55 publications

(40 citation statements)

References 47 publications

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“…Although this relation is not consistent in literature, the mechanisms that support cancer prevention are the decrease of cell proliferation and tumor endothelial cell adhesion, decrease of inflammation, and increase of apoptosis [25]. The relationship with CVD prevention is based on the decrease of triglycerides, blood pressure, thrombosis, and cardiac arrhythmias and on the increase of endothelial relaxation induced by nitric oxide [26].…”

Section: Introductionmentioning

confidence: 93%

Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents

et al. 2015

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Section: Introductionmentioning

confidence: 93%

Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents

et al. 2015

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“…Recently, an endothelial regenerative effect of omega-3 PUFA has been demonstrated in low cardiovascular risk patients. In these patients, omega-3 PUFA promoted the production of endothelial progenitor cells and reduced the presence of endothelial cell-damaged microparticles [49].…”

Section: Omega-3 Pufa In Mechanisms Of Endothelial Dysfunctionmentioning

confidence: 87%

Omega-3 Polyunsaturated Fatty Acids in Blood Pressure Control and Essential Hypertension

Colussi¹,

Catena²,

Novello³

et al. 2016

Update on Essential Hypertension

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Hypertension is a worldwide problem that affects up to % of adults and contributes to the global burden of disability due to cardiovascular disease. Several factors influence blood pressure and participate to the development of hypertension. "mong these factors, polyunsaturated fatty acids of the omega-family omega-PUF" are effective hypotensive agents. Through their anti-inflammatory and antioxidant properties, omega-PUF" can improve cardiac hemodynamics and vascular function and potentially reduce arterial stiffness and atherosclerotic damage. However, despite this promising evidence many meta-analyses on the cardiovascular effect of omega-PUF" were inconclusive. The choice of the omega-PUF" sources, baseline tissue content of these fatty acids, and individual compliance to their intake can be reasons for such a discrepancy between studies. "asic and clinical research on these fatty acids documents interesting mechanisms through which these molecules could be useful in the treatment of hypertension and its related organ damage. The role of the maternal dietary habit during pregnancy and the quality of prenatal growth on the effect of omega-PUF" in cardiovascular system need further investigations. This chapter summarizes the literature of the past years on the antihypertensive effects of this family of essential fatty acids.

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“…Recent work exploring cellular mechanisms for the effects of LC n ‐3 PUFA on vascular function has demonstrated that they lower circulating levels of endothelial microparticles, thought to be produced as a result of damage to the endothelium, and increase numbers of endothelial progenitor cells, which are associated with vascular repair and angiogenesis (Wu et al . ).…”

Section: Diet Immunity and Cancermentioning

confidence: 97%

“…There is some evidence for anti-inflammatory effects of LC n-3 PUFA, which may contribute to lowering of CVD risk and beneficial effects on vascular function (Calder & Yaqoob 2012). Recent work exploring cellular mechanisms for the effects of LC n-3 PUFA on vascular function has demonstrated that they lower circulating levels of endothelial microparticles, thought to be produced as a result of damage to the endothelium, and increase numbers of endothelial progenitor cells, which are associated with vascular repair and angiogenesis (Wu et al 2014).…”

Section: Diet Immunity and Cancermentioning

confidence: 99%

The Hugh Sinclair Unit of Human Nutrition – 20 years of research 1995–2015

et al. 2015

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The Hugh Sinclair Unit of Human Nutrition (HSUHN) at the University of Reading was founded in October 1995 with the appointment of Christine Williams OBE as the first Hugh Sinclair Chair in Human Nutrition. This was made possible by the competitively won funds from the estate and legacy of the late Professor Hugh Macdonald Sinclair (1910–1990). The vision for the newly established HSUHN was to ‘strengthen the evidence base for dietary recommendations for prevention of degenerative chronic diseases’. This has remained the research focus of the HSUHN under the leadership of Professors Christine Williams (1995–2005), Ian Rowland (2006–2013) and Julie Lovegrove (2014‐present). Our mission is to improve population health and evaluate mechanisms of action for the effects of dietary components on health, which reflects Hugh Sinclair's life ambition within nutritional science. Over the past 20 years, the HSUHN has developed an international reputation within the nutrition science community, and in recognition of the 20th anniversary, this paper highlights Hugh Sinclair's contributions to the field of nutrition and key research achievements by members of the Unit.

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Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of eNOS genotype

Cited by 55 publications

References 47 publications

Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents

Relationships between n-3 polyunsaturated fatty acid intake, serum 25 hydroxyvitamin D, food consumption, and nutritional status among adolescents

Omega-3 Polyunsaturated Fatty Acids in Blood Pressure Control and Essential Hypertension

The Hugh Sinclair Unit of Human Nutrition – 20 years of research 1995–2015

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