Fish Oil Improves the Lipid Profile and Reduces Inflammatory Cytokines in Wistar Rats With Precancerous Colon Lesions

Rosa, Damiana Diniz; Lourenço, Fabíola Cesário; Fonseca, Ana Carolina Machado da; Sales, Regiane Lopes de; Ribeiro, Sônia Machado Rocha; Neves, Clóvis Andrade; Pelúzio, Maria do Carmo Gouveia

doi:10.1080/01635581.2012.665563

Cited by 12 publications

(9 citation statements)

References 44 publications

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“…In agreement, ω -3 PUFAs were found to inhibit in vitro the expression of IL-1 β and IL-6 cytokines in AR42J pancreas acinar tumor cells stimulated by the pancreatitis-inducer cerulean [110]. Moreover, recently Rosa et al [111] found that in rats treated with fish oil (FO) (Galena FO, 4% w/w) and subjected to 1,2-dimethylhydrazine (DHM)-induced colon carcinogenesis a lower incidence of aberrant crypt foci (ACF) was observed as compared to soybean-oil-treated rats (controls), confirming a wide series of previous observation [112]. Interestingly, the authors suggested the existence of a relationship between the anticancer effect of ω -3 PUFAs and their anti-inflammatory effect, since they observed an increased expression of the immunosuppressive factor TGF- β and a decreased expression of the pro-inflammatory and pro-angiogenic chemokine IL-8 in the colonic mucosa of DHM-treated rats fed with a FO-enriched diet.…”

Section: Beneficial Effects Of ω-3 Pufas In Cancer: Involvement Ofmentioning

confidence: 71%

Experimental Evidence ofω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Calviello

Weylandt

et al. 2013

BioMed Research International

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A large body of evidence has emerged over the past years to show the critical role played by inflammation in the pathogenesis of several diseases including some cardiovascular, neoplastic, and neurodegenerative diseases, previously not considered inflammation-related. The anti-inflammatory action of ω-3 polyunsaturated fatty acids (PUFAs), as well as their potential healthy effects against the development and progression of the same diseases, has been widely studied by our and others' laboratories. As a result, a rethinking is taking place on the possible mechanisms underlying the beneficial effects of ω-3 PUFAs against these disorders, and, in particular, on the influence that they may exert on the molecular pathways involved in inflammatory process, including the production of inflammatory cytokines and lipid mediators active in the resolving phase of inflammation. In the present review we will summarize and discuss the current knowledge regarding the modulating effects of ω-3 PUFAs on the production of inflammatory cytokines and proresolving or protective lipid mediators in the context of inflammatory, metabolic, neurodegenerative, and neoplastic diseases.

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Section: Beneficial Effects Of ω-3 Pufas In Cancer: Involvement Ofmentioning

confidence: 71%

Experimental Evidence ofω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Calviello

Weylandt

et al. 2013

BioMed Research International

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“…The FA methyl esters were identified by gas chromatography (CG-17A Shimadzu ® /Class model) (25). Peak identification was made by comparison of their retention times with that of a mixture of commercial standards (FAME mix, Supelco ® , USA).…”

Section: Fatty Acids In Breast Adipose Tissuementioning

confidence: 99%

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

Conceição¹,

Dias²,

Pessoa³

et al. 2017

Nutr Hosp

Self Cite

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Introduction: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle.Objectives: Evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγpolymorphism.Material and Methods: A hospital-based case-control study was conducted including incident cases (n = 38 breast cancer; n = 75 benign breast disease; n = 166 control). Lifestyle features, socioeconomic issues, dietary intake, anthropometry, and blood and tissue data were assessed.Results: No differences were observed for fatty acids intake. Interestingly, lauric acid (P = 0.001), myristic acid (P = 0.036), stearic acid (P = 0.031), and total saturated fatty acids (SFAs) (P=0.048) had lower concentrations in BC than in BBD women, while palmitoleic acid (P = 0.022), erucic acid (P = 0.002), total monounsaturated fatty acids (MUFAs) (P = 0.039) and oleic acid/stearic acid ratio (P = 0.015) increased. There was no significant association between PPARγ polymorphism and studied groups (P = 0.977). The age at first full pregnancy (P = 0.004) was significantly associated with the development BC, whereas BMI (P = 0.005); percentage of body fat (P = 0.024); physical activity (P = 0.036); and age at menarche (P = 0.008), at first full pregnancy (P < 0.001), and of first mammogram (P = 0.018) were significantly associated with the development of BBD.Conclusion: The results suggest a different fatty acids composition of breast adipose tissue, a biomarker of long-term dietary intake, particularly for SFAs, MUFA and 18: 1 n-9/18: 00 ratio. Our findings also show that are differences in the factors related to the development of BC and BBC.

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“…Lower levels of aberrant crypt foci were found in rats fed with ω 3 PUFA. In addition, this group of carcinogen-treated rats showed greater expression of transforming growth factor β and lower interleukin-8 expression, resulting in a protective effect on the colonic precancerous mucosa and a beneficial effect on inflammatory modulation [39]. Using the Fat-1 mice, a genetic model that synthesizes long-chain ω-3 PUFAs de novo , it was shown that ω-3 PUFAs can modulate the colonic mucosal microenvironment to suppress Th17 cell accumulation and inflammatory damage following the induction of chronic colitis [40].…”

Section: Marine Lipidsmentioning

confidence: 99%

Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

Stonik

Fedorov

2014

Marine Drugs

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Due to taxonomic positions and special living environments, marine organisms produce secondary metabolites that possess unique structures and biological activities. This review is devoted to recently isolated and/or earlier described marine compounds with potential or established cancer preventive activities, their biological sources, molecular mechanisms of their action, and their associations with human health and nutrition. The review covers literature published in 2003–2013 years and focuses on findings of the last 2 years.

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Fish Oil Improves the Lipid Profile and Reduces Inflammatory Cytokines in Wistar Rats With Precancerous Colon Lesions

Cited by 12 publications

References 44 publications

Experimental Evidence ofω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Experimental Evidence ofω-3 Polyunsaturated Fatty Acid Modulation of Inflammatory Cytokines and Bioactive Lipid Mediators: Their Potential Role in Inflammatory, Neurodegenerative, and Neoplastic Diseases

Difference in fatty acids composition of breast adipose tissue in women with breast cancer and benign breast disease

Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

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