Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

Stonik, Valentin A.; Fedorov, Sergey N.

doi:10.3390/md12020636

Cited by 48 publications

(33 citation statements)

References 143 publications

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“…Extensive recent reviews have been published on the potential of seaweed as a source of drugs for use in cancer chemotherapy (Murphy et al 2014;Stonik and Fedorov 2014). Glucan oligomers, for example, hydrolysed from laminarin extracted from kelp, inhibit the proliferation of human leukaemia U937 cells (Pang et al 2005).…”

Section: Cancer Chemotherapymentioning

confidence: 99%

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Milledge

Nielsen

Bailey³

2015

Rev Environ Sci Biotechnol

145

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Marine seaweeds represent an abundant source of natural products and may harbour valuable chemicals. The brown seaweed Sargassum muticum is an invasive species to the coasts of the British Isles, mainland Europe and North America. Attempts at its eradication and control have generally not been successful, although time-consuming and costly. Commercial exploration of this biomass for food, fuel and pharmaceutical products could encourage its harvesting and control. Though S. muticum might be unsuitable as a source of biofuel due to high ash and water content, this rapidly growing macroalga has a naturally high content of antioxidants, carotenoids and phenols, including the well-known anti-cancer compound fucoxanthin, making this species a potential source of a range of pharmaceutically relevant materials.

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Section: Cancer Chemotherapymentioning

confidence: 99%

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Milledge

Nielsen

Bailey³

2015

Rev Environ Sci Biotechnol

145

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“…Marine natural products are one of the most interesting targets for global drug discovery since they not only possess structural and chemical uniqueness but also represent novel scaffolds for drug development [34]. Marine natural products have also been studied and tested alongside with synthetic compounds as ABC transporter inhibitors [29,[35][36][37][38]. The development of anticancer drugs from marine compounds is one of the most promising approaches in drug discovery with therapeutic agents in clinical practice, such as the anticancer trabectedin [37].…”

Section: Introductionmentioning

confidence: 99%

Marine Natural Products as Models to Circumvent Multidrug Resistance

et al. 2016

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Multidrug resistance (MDR) to anticancer drugs is a serious health problem that in many cases leads to cancer treatment failure. The ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which leads to premature efflux of drugs from cancer cells, is often responsible for MDR. On the other hand, a strategy to search for modulators from natural products to overcome MDR had been in place during the last decades. However, Nature limits the amount of some natural products, which has led to the development of synthetic strategies to increase their availability. This review summarizes the research findings on marine natural products and derivatives, mainly alkaloids, polyoxygenated sterols, polyketides, terpenoids, diketopiperazines, and peptides, with P-gp inhibitory activity highlighting the established structure-activity relationships. The synthetic pathways for the total synthesis of the most promising members and analogs are also presented. It is expected that the data gathered during the last decades concerning their synthesis and MDR-inhibiting activities will help medicinal chemists develop potential drug candidates using marine natural products as models which can deliver new ABC transporter inhibitor scaffolds.

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“…makes marine organisms an important and almost unlimited field of basic and applied research. Moreover, they can synthesize unique chemical structures, most of them with potent bioactivities [10]. Interestingly, some marine organisms, such as microalgae, may be used as natural bioreactors potentiating the synthesis of valuable compounds depending on the cultivation conditions.…”

Section: Marine Resourcesmentioning

confidence: 99%

Green processes and sustainability: An overview on the extraction of high added-value products from seaweeds and microalgae

Herrero

Ibáñez

2015

The Journal of Supercritical Fluids

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Marine Low Molecular Weight Natural Products as Potential Cancer Preventive Compounds

Cited by 48 publications

References 143 publications

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

High-value products from macroalgae: the potential uses of the invasive brown seaweed, Sargassum muticum

Marine Natural Products as Models to Circumvent Multidrug Resistance

Green processes and sustainability: An overview on the extraction of high added-value products from seaweeds and microalgae

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