Fish-oil esters of plant sterols improve the lipid profile of dyslipidemic subjects more than do fish-oil or sunflower oil esters of plant sterols

Abstract

Supplementation of an OO-based diet with FO-PS may reduce cardiovascular disease risk more than does supplementation with fish oil or SU-PS.

Phytosterol stearate esters elicit similar responses on plasma lipids and cholesterol absorption but different responses on fecal neutral sterol excretion and hepatic free cholesterol in male Syrian hamsters

“…2 Sum of brassicasterol, campesterol, stigmasterol, sitosterol, and sitostanol. 3 Phytosterol treatment indicates quantification of the specific treatment phytosterol only. 4 Free treatment phytosterol to total treatment phytosterol ratio is referred to as net hydrolysis.…”

“…Both free and fatty acid-esterified phytosterols decrease serum studies. Fish oil phytosterol esters have demonstrated equal effectiveness as sunflower oil phytosterol esters in lowering LDL cholesterol but have the added benefit of reducing plasma triglycerides [3], indicating that the fish oil phytosterol esters maintain the favorable therapeutic effects of both the fatty acid and the phytosterol [4]. Phytosterols esterified to stearate-enriched fatty acid mixtures have demonstrated an ability to decrease LDL cholesterol in humans [5] and a superior plasma nonhigh-density lipoprotein (non-HDL) cholesterol-lowering efficacy compared with linoleate-enriched esters in hamsters [6].…”

High Fibre Diets and Alzheimer’s Disease

“…Phytosterol esters with fish oil have been found to lower the plasma cholesterol levels than conventional phytosterol esters [155]. Furthermore, this synergistic supplement has a more hypotriglyceridemic effect than the conventional fish oil [155]. Esterification of phytosterol with oleic acid and esterification of beta sitosterol with conjugated linoleic acid have been previously reported [156].…”

“…Esterification of phytosterol with short chain fatty acids may improve its integration into a variety of foods without disturbing the efficiency of phytosterol as with omega 3 fatty acids and phytosterol. Phytosterol esters with fish oil have been found to lower the plasma cholesterol levels than conventional phytosterol esters [155]. Furthermore, this synergistic supplement has a more hypotriglyceridemic effect than the conventional fish oil [155].…”

Plant sterols for human health- A review

“…PS are natural components of human diets (Weihrauch and Gardner, 1978;Phillips et al, 2005). An average daily intake of PS from natural sources is estimated between 150 and 440mg in Western countries (Ostlund, 2002;Jimenez-Escrig et al, 2006) Need of fortification: Phytosterols has been known for its cholesterol lowering action since 1950s (Russel et al, 2002;Demonty et al, 2006;Ortega et al, 2006;Acuff et al, 2007;Earnest et al 2007;Marangoni and Poli, 2010;Rocette et al, 2010). ß-sitosterol had been used as a supplement and as a drug to lower serum cholesterol for a long time.…”