Fish-oil dietary supplementation in patients with Raynaud's phenomenon: A double-blind, controlled, prospective study

Digiacomo, Ralph; Kremer, Joel M.; Shah, Dhiraj M.

doi:10.1016/0002-9343(89)90261-1

Cited by 144 publications

(65 citation statements)

References 22 publications

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“…These PUFAs have been reported to show anti-inflammatory effects in patients with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and chronic inflammatory bowel disease (18)(19)(20)(21)(22)(23)(24). Several reports have focused on the beneficial effects of EPAor fish oil on bronchial asthma (25)(26)(27)(28)(29).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

et al. 2000

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Objective The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes.Methods and Subjects 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumedperilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTsby leucocytes and respiratory function were comparedbetween the two groups.Results The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV1 0 (p<0.05) and V25 (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV1 0 (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation.Conclusion These results suggest that perilla seed oilrich supplementation is useful for the treatment of asthma in terms of suppression of LTB4and LTC4generation by leucocytes, and improvement of pulmonary function.

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Section: Discussionmentioning

confidence: 99%

Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

et al. 2000

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“…Putting these two observations together, he postulated that fish oils may be beneficial for persons with Raynaud's. This was later confirmed (DiGiacomo et al, 1989). Although the original discovery was made using the closed approach, we first apply the open procedure (Gordon & Lindsay, 1996;Weeber et al, 2001) and then the closed one (Weeber et al, 2001).…”

Section: Fish Oils and Raynaud's Diseasementioning

confidence: 61%

Text mining: Generating hypotheses from MEDLINE

Srinivasan

2003

J. Am. Soc. Inf. Sci.

241

186

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Hypothesis generation, a crucial initial step for making scientific discoveries, relies on prior knowledge, experience, and intuition. Chance connections made between seemingly distinct subareas sometimes turn out to be fruitful. The goal in text mining is to assist in this process by automatically discovering a small set of interesting hypotheses from a suitable text collection. In this report, we present open and closed text mining algorithms that are built within the discovery framework established by Swanson and Smalheiser. Our algorithms represent topics using metadata profiles. When applied to MEDLINE, these are MeSH based profiles. We present experiments that demonstrate the effectiveness of our algorithms. Specifically, our algorithms successfully generate ranked term lists where the key terms representing novel relationships between topics are ranked high.

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“…If a hypothesized link turns out to be fruitful, it leads to new medical knowledge such as a treatment for a currently untreatable disease, a treatment that is more cost efficient or has fewer side effects, or an advance in basic science. Subsequent to Swanson's work on Raynaud's, DiGiacomo, Kremer, & Shah (1989) conducted clinical tests and determined that secondary, but not primary, Raynaud's could be effectively treated by fish oil. Migraine/magnesium connections have also been published after the dates used to establish the literature-based connection (Castelli, Meossi, Domenici, Fontana, & Stefani, 1993;Gallai, Sarchielli, Morucci, & Abbritti, 1993).…”

Section: Discussionmentioning

confidence: 99%

Literature-based discovery by lexical statistics

Lindsay

Gordon

1999

J. Am. Soc. Inf. Sci.

131

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We report experiments that use lexical statistics, such as word frequency counts, to discover hidden connections in the medical literature. Hidden connections are those that are unlikely to be found by examination of bibliographic citations or the use of standard indexing methods and yet establish a relationship between topics that might profitably be explored by scientific research. Our experiments were conducted with the MEDLINE medical literature database and follow and extend the work of Swanson.

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Fish-oil dietary supplementation in patients with Raynaud's phenomenon: A double-blind, controlled, prospective study

Cited by 144 publications

References 22 publications

Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

Text mining: Generating hypotheses from MEDLINE

Literature-based discovery by lexical statistics

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