Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

Okamoto, Makoto; Mitsunobu, Fumihiro; Ashida, Kozo; Mifune, Takashi; Hosaki, Yasuhiro; Tsugeno, Hirofumi; Harada, Seishi; Tanizaki, Yoshiro

doi:10.2169/internalmedicine.39.107

Cited by 66 publications

(38 citation statements)

References 29 publications

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“…Our results are in accord with Poerschmann et al, who showed that the unsaturation index of FAs in algae and bacteria tends to be higher in colder climates than in warmer climates [70,74]. -3 PUFAs, but not -6 PUFAs, mono-unsaturated FAs or saturated FAs, have been shown to be potent NF-B inhibitors [75][76][77][78][79][80]. One would hence have expected the CCMP 1619 extract, which has a twelve times higher concentration in -3 PUFA than the remaining extracts, to stand out as the strongest NF-B inhibitor.…”

Section: Discussionsupporting

confidence: 92%

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Folmer

Jaspars

Solano

et al. 2009

Biochemical Pharmacology

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, et al.. The inhibition of TNF-α induced NF-κB activation by marine natural products. Biochemical Pharmacology, Elsevier, 2009, 78 (6) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 AbstractThe deregulated activation of NF-B is associated with cancer development and inflammatory diseases. With the aim to find new NF-B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins.Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF--induced NF-B-DNA binding as well as TNF- induced IB degradation and nuclear translocation of p50/p65. Furthermore, we observed inhibition of NF-B activation induced by an overexpression of TNFR1, TRAF2, TRADD, or IKK Interestingly, natural products inhibited IKK kinase as well as the 26S proteasome proteolytic activity.

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Section: Discussionsupporting

confidence: 92%

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Folmer

Jaspars

Solano

et al. 2009

Biochemical Pharmacology

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“…Our observations support previous findings in patients with allergic disease in whom n–3 PUFA supplementation reduced the generation of inflammatory leukotrienes and prostaglandins [13, 16, 17, 30]. Repeated low-dose allergen challenge promotes features of airway inflammation, thus mimicking the natural course of allergic asthma more closely than a single high-dose allergen inhalation challenge [19].…”

Section: Discussionsupporting

confidence: 90%

“…In keeping with this observation, no clinical improvement in asthmatic symptoms was detected in some interventional studies [13, 14]. However, other studies have demonstrated a benefit of n–3 PUFA supplementation in patients suffering from bronchial asthma [15,16,17]. The inconsistency among study results may be attributable to the heterogeneity of the populations (e.g.…”

Section: Introductionmentioning

confidence: 79%

Effect of n–3 Polyunsaturated Fatty Acids in Asthma after Low-Dose Allergen Challenge

Schubert

Kitz

Beermann

et al. 2008

Int Arch Allergy Immunol

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Background: We investigated the anti-inflammatory potential of n–3 polyunsaturated fatty acids (PUFA) on specific bronchial inflammation. Allergic asthmatics were challenged using a low-dose allergen provocation model. Methods: Our parallel double-blinded study randomly assigned 23 house dust mite-allergic asthmatics (aged 22–29 years; 13 females, 10 males) to dietary supplementation with either an n–3 PUFA-enriched fat blend (0.69 g/day) or placebo for 5 weeks. After 3 weeks, the patients were challenged daily with low doses of mite allergen for 2 weeks. Primary outcome parameters were effects on lung function (forced expiratory volume in 1 s, FEV₁) and exhaled nitric oxide (eNO) as a marker of bronchial inflammation. Results: Even before the bronchial challenge, eNO was significantly lower in the n–3 PUFA group (p = 0.014). Levels of eNO increased during allergen exposure in both groups, but differences in means were significantly lower in the n–3 PUFA group (p = 0.022). During the low-dose allergen challenge, there were no differences between the groups with regard to symptoms, FEV₁ or the allergen dose required to induce deterioration of lung function (PD₂₀). Numbers of sputum eosinophils did not differ significantly, while serum eosinophils (10.1 ± 0.1.84 vs. 5.79 ± 0.69%) as well as changes in eosinophilic cationic protein (20.5 ± 9.93 vs. –1.68 ± 4.36 ng/ml) and in vitro cysteinyl leukotriene release (2,889 ± 872 vs. 1,120 ± 173 ng/ml) were significantly lower in the n–3 PUFA group (p < 0.05 each). Conclusion: Our results provide evidence that dietary supplementation with n–3 PUFA is able to reduce bronchial inflammation even after low-dose allergen challenge.

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“…The most dramatic beneficial effect is demonstrated in subjects with exercise induced bronchoconstriction, in whom supplementation with n-3 fatty acid significantly reduced the fall in FEV 1 following exercise 27 40. Other studies found a positive effect in patients with asthma on respiratory health following supplementation 19 20 28 29. In contrast, a number of studies have found no change in respiratory health following supplementation41 – 47 but two of these did find a reduction in leukotrienes,41 42 another study found a reduction in thromboxane b2 with supplementation of n-3 fatty acids47 and finally one study found a reduction in tumour necrosis factor α in the group supplemented with n-3 fatty acids 46…”

Section: Discussionmentioning

confidence: 99%

The relation between dietary intake of individual fatty acids, FEV₁ and respiratory disease in Dutch adults

McKeever

Lewis

Cassano

et al. 2007

Thorax

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Background:A reduced dietary intake of n-3 fatty acids, in association with increased n-6 fatty acid intake, has been proposed as a potential aetiological factor for chronic obstructive pulmonary disease (COPD) and asthma. However, the relative importance of individual fatty acids within the n-3 and n-6 categories on this effect has not been widely investigated. We have studied the relation between individual fatty acid intakes, lung function and self-reported respiratory symptoms and diagnoses in a representative sample of more than 13 000 Dutch adults.Methods:Intake of individual fatty acids was estimated by a food frequency questionnaire and analysed in relation to measures of forced expiratory volume in 1 s (FEV1) and to questionnaire reported wheeze, asthma and COPD symptoms.Results:After adjusting for confounding, we found no protective association between individual n-3 fatty acid intakes and FEV1. Higher intakes of some n-6 fatty acids were associated with lower FEV1, this effect being most marked for c22:4 n-6 docosatetraenoic acid (reduction in FEV1 between the highest and lowest quintile of intake 54.5 ml (95% CI −81.6 to −27.4)). Most of the n-6 fatty acid effects interacted significantly with smoking, their effects being strongest in current smokers. Individual n-3 fatty acid intakes were generally associated with a higher risk of wheeze in the past year, but otherwise there was little or no association between fatty acid intake and wheeze, doctor diagnosed asthma or other respiratory symptoms.Conclusions:A high intake of n-3 fatty acids does not appear to protect against COPD or asthma, but a high intake of several n-6 fatty acids is associated with a significant reduction in FEV1, particularly in smokers. These findings indicate that high dietary intake of n-6 fatty acids, rather than reduced n-3 intake, may have an adverse effect on lung health.

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Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

Cited by 66 publications

References 29 publications

The inhibition of TNF-α-induced NF-κB activation by marine natural products

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Effect of n–3 Polyunsaturated Fatty Acids in Asthma after Low-Dose Allergen Challenge

The relation between dietary intake of individual fatty acids, FEV₁ and respiratory disease in Dutch adults

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Effects of Dietary Supplementation with n-3 Fatty Acids Compared with n-6 Fatty Acids on Bronchial Asthma.

Cited by 66 publications

References 29 publications

The inhibition of TNF-α-induced NF-κB activation by marine natural products

The inhibition of TNF-α-induced NF-κB activation by marine natural products

Effect of n–3 Polyunsaturated Fatty Acids in Asthma after Low-Dose Allergen Challenge

The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults

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Product

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The relation between dietary intake of individual fatty acids, FEV₁ and respiratory disease in Dutch adults