Fish Oil and Primrose Oil Suppress the Progression of Alzheimer’s Like Disease Induced by Aluminum in Rats

Al‐Okbi, Sahar Y.; Mohammed, Shaimaa; Al-Siedy, Enas S.K.; Ali, Naglaa A.

doi:10.5650/jos.ess20015

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…injection of D-Gal for 6 weeks. Aluminium was successful in induction of AD model in rats by some of the authors in the present research [17,36,37]. These results encourage us for studying the effect of D-Gal and AlCl 3 combination in induction of AD in rats as both of them are neurotoxic.…”

Section: Discussionsupporting

confidence: 70%

Ameliorative Effect of Probiotic-Fermented Milk and Costus Extract in Alzheimer’s Disease Model Induced by D-Galactose and Aluminum Chloride

et al. 2021

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Alzheimer's disease (AD) is a neurodegenerative disease associated with memory and cognitive dysfunction and is the main reason of dementia worldwide. The present research aimed to evaluate the protective effect of administration of probioticfermented milk and costus extract against AD in rats. Total phenolic content (TPC), total flavonoids (TF) and antioxidants activity (AA) of costus extracts were studied. The study included 40 rats divided into five groups. Group 1 and 2 served as normal control and AD control, respectively. Groups 3 and 4 were given daily oral dose of costus extract (100 and 200mg/KG RBW), while group 5 was given probiotic-fermented milk (1 ml/rat/day). AD was induced in rats by intraperitoneally (i.p.) injection of D-galactose and aluminium chloride for 21 days. Hippocampal gene expression of PI3K and Akt, biochemical, nutritional and histopathological studies were evaluated in all rats' groups. Microflora of fecal samples from cecum and colon were studied in group 1, 2 and 5. Costus root extract showed 98% AA and contains TPC and TF as 378.1 mg GAE/g and 275.3 mg/g extract, respectively. Induction of AD in rats led to reduction of mRNA level of PI3K and Akt in hippocampal of rats, also elevation of inflammatory and oxidative stress markers in association with significant elevation of acetylcholinesterase activity were observed. The results revealed relevant new visions towards the influences of probioticfermented milk and costus extract on cognitive function through reduction of neurofibrillary tangles formations, regulation of hippocampal gene expression of PI3K and Akt, inflammatory and oxidative stress markers. Conclusion: Administration of probiotic-fermented milk and costus extract have a promising effect on cognitive function through reduction of neurofibrillary tangles formation, regulation of hippocampal gene expression of PI3K and Akt, inflammatory and oxidative stress markers. The present results suggested that intake of probiotic-fermented milk had a beneficial effect on the composition of cecum and colon flora. Probiotic-fermented milk was the most effective for prevention of AD in the present study.

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Section: Discussionsupporting

confidence: 70%

Ameliorative Effect of Probiotic-Fermented Milk and Costus Extract in Alzheimer’s Disease Model Induced by D-Galactose and Aluminum Chloride

et al. 2021

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“…BChE activity in human subjects is related to the hepatobiliary disease, hyperlipidemia, diabetes and cardiovascular disease in adult patients ( 36 ) . Moreover, there was a report that BChE levels of Alzheimer's-like disease model rats were significantly higher than those of control rats ( 37 ) .…”

Section: Discussionmentioning

confidence: 99%

Effect of fish paste products, fish balls ‘tsumire’, intake in Sprague–Dawley rats

Kadokura¹,

Tomita²,

Suruga³

2021

J Nutr Sci

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The fish paste product, fish balls ‘tsumire’, is a traditional type of Japanese food made from minced fish as well as imitation crab, kamaboko and hanpen. Although tsumire is known as a high-protein and low-fat food, there is a lack of scientific evidence on its health benefits. Hence, we aimed to investigate the effects of tsumire intake on organ weight and biomarker levels in Sprague–Dawley rats for 84 d as a preliminary study. Six-week-old male Sprague–Dawley rats were divided into two groups: group I, fed normal diets, and group II, fed normal diets with 5 % dried tsumire. Throughout the administration period, we monitored their body weight and food intake; at the end of this period, we measured their organ weight and analysed their blood biochemistry. No significant differences were observed with respect to body weight, food intake, organ weight and many biochemical parameters between the two groups. It was found that inorganic phosphorus and glucose levels were higher in group II rats than in group I rats. On the other hand, sodium, calcium, amylase and cholinesterase levels were significantly lower in group II than in group I. Interestingly, we found that the levels of aspartate aminotransferase, alanine transaminase, lactate dehydrogenase and leucine aminopeptidase in group II were significantly lower than in group I, and that other liver function parameters of group II tended to be lower than in group I. In conclusion, we consider that the Japanese traditional food, ‘tsumire,’ may be effective as a functional food for human health management worldwide.

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“…The predominant components of primrose are phenol compounds, which confer its antioxidant and free radical scavenging properties. Primrose reportedly contains 9.24% gamma-linolenic acid, 73.88% linoleic acid, and 6.93% oleic acid, along with other components [ 7 ]. Gamma-linolenic acid in primrose is regarded as an anti-inflammatory eicosanoid precursor.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that primrose's ethanolic extracts exhibit antioxidant effects [ 20 ], and its methanolic extracts potentially have antioxidant properties [ 21 ]. Previous research suggested that primrose could reverse neuro-conduction disorders in diabetic rats [ 22 ]; halt Alzheimer's progression in rats; and significantly enhance cognitive function, vitality, and quality of life in patients with multiple sclerosis [ 7 , 8 ]. To our knowledge, the present study is the first to examine the effects of primrose on SCI.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study

Çavuş,

Yılmaz,

Tascanov

et al. 2023

Heliyon

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Fish Oil and Primrose Oil Suppress the Progression of Alzheimer’s Like Disease Induced by Aluminum in Rats

Cited by 5 publications

References 33 publications

Ameliorative Effect of Probiotic-Fermented Milk and Costus Extract in Alzheimer’s Disease Model Induced by D-Galactose and Aluminum Chloride

Ameliorative Effect of Probiotic-Fermented Milk and Costus Extract in Alzheimer’s Disease Model Induced by D-Galactose and Aluminum Chloride

Effect of fish paste products, fish balls ‘tsumire’, intake in Sprague–Dawley rats

Efficacy of combination of N-acetylcysteine and primrose in spinal cord injury; an experimental study

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