Fish (Fluorescence in situ hybridization) to Detect Effects of Smoking, Caffeine, and Alcohol on Human Sperm Chromosomes

Reproductive pathology in the male represents about 20% of infertility cases. Male infertility may be attributed to a number of causes, including genetic and congenital abnormalities, infection, multisystemic diseases, varicocele, and others; however, a significant number of cases are idiopathic. Global declines in semen quality were suggested to be associated with enhanced exposure to environmental chemicals that act as endocrine disrupters as a result of our increased use of pesticides, plastics, and other anthropogenic materials. A significant body of toxicology data based upon laboratory and wildlife animals studies suggests that exposure to certain endocrine disrupters is associated with reproductive toxicity, including (1) abnormalities of the male reproductive tract (cryptorchidism, hypospadias), (2) reduced semen quality, and (3) impaired fertility in the adult. There is, however, a relative paucity of studies designed to measure exposure to endocrine disrupters on semen quality parameters (sperm concentration, motility, morphology). An overview of the human semen quality literature is presented that examines the role of endocrine disrupters including organochlorines (OC), dioxins, phthalates, phytoestrogens, and chemical mixtures (pesticides and tobacco smoke).

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Paternally Mediated Effects on Development

Robaire¹,

Hales²

2005

Developmental and Reproductive Toxicology

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Fish (Fluorescence in situ hybridization) to Detect Effects of Smoking, Caffeine, and Alcohol on Human Sperm Chromosomes

Cited by 3 publications

References 108 publications

Flow cytometry applications in the evaluation of sperm quality: semen analysis, sperm function and DNA integrity

Flow cytometry applications in the evaluation of sperm quality: semen analysis, sperm function and DNA integrity

Human Exposure to Endocrine Disrupters and Semen Quality

Paternally Mediated Effects on Development

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