Fish, docosahexaenoic acid and Alzheimer’s disease

Cunnane, Stephen C.; Plourde, Mélanie; Pifferi, Fabien; Bégin, Michel E.; Féart, Catherine; Barberger‐Gateau, Pascale

doi:10.1016/j.plipres.2009.04.001

Cited by 282 publications

(220 citation statements)

References 182 publications

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“…Hence, the MeDi could contribute to postpone disability in B-IADL by slowing down cognitive decline in older persons. Indeed, the MeDi provides dietary antioxidants, from fruits and vegetables, B vitamins, from cereals and green leafy vegetables and omega3 fatty acids, from fish, whose protective role against brain aging has been suggested by many observational studies [49][50][51]. This effect was independent of baseline cognitive performance and cardiovascular risk factors in our study.…”

Section: Discussionsupporting

confidence: 65%

Adherence to a Mediterranean diet and onset of disability in older persons

et al. 2011

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Section: Discussionsupporting

confidence: 65%

Adherence to a Mediterranean diet and onset of disability in older persons

et al. 2011

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“…In particular, EPA plus DHA are most important elements related to the benefits of marine food consumption, including the prevention of various circulatory diseases, neurodevelopment in infants, and Alzheimer s disease in aged people 11,12,31 . In general, highly migratory fishes, such as K. pelamis, are considered one of the most practical sources of n-3 PUFA.…”

Section: Lipid Content Of the Three Myctophids And K Pelamismentioning

confidence: 99%

Lipid and Fatty Acids of Three Edible Myctophids, Diaphus watasei, Diaphus suborbitalis, and Benthosema pterotum: High Levels of Icosapentaenoic and Docosahexaenoic Acids

2014

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“…In particular, basic research as well as epidemiological studies suggest a protective effect of long-chain omega3 polyunsaturated fatty acids (LC n-3 PUFA) against pathological brain aging and cognitive decline (Barberger Cunnane et al, 2009). However, most randomized controlled trials (RCT) with LC n-3 PUFA supplements have been disappointing regarding cognitive outcomes in older persons (Jiao et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Long-chain omega3 polyunsaturated fatty acids and cognition in older people: interaction with APOE genotype

Barberger‐Gateau

Samieri

Cunnane³

2015

OCL

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-Basic research and epidemiological studies suggest a protective effect of long-chain omega3 polyunsaturated fatty acids (LC n-3 PUFA) against age-related cognitive decline. However, most randomized controlled trials with LC n-3 PUFA supplements have yielded disappointing results on cognitive outcomes in older persons. One explanation for this discrepancy may be an inadequate targeting of potential beneficiaries of LC n-3 PUFA according to their Apolipoprotein E (APOE) genotype. The aim of this paper was to examine the potential modifying effect of APOE genotype on LC n-3 PUFA metabolism and its relation to cognitive decline in older persons. At least five epidemiological studies and three intervention studies with LC n-3 PUFA supplements have found an interaction between LC n-3 PUFA and APOE genotype on cognition. However, the direction of the effect is inconsistent across studies: the impact of LC n-3 PUFA on cognition is stronger in APOE4 carriers (the main genetic risk factor for Alzheimer's disease) in some studies, but conversely stronger in APOE4 non-carriers in other studies. These discordant results may be explained by different age groups, cognitive status, measures of cognition, or amounts of DHA intake across studies. Experimental studies suggest that the APOE4 genotype modifies the metabolism of DHA. The APOE genotype should be systematically taken into account and interactions tested in epidemiological and intervention studies with LC n-3 PUFA. Further research is needed to better understand the underlying mechanisms of this gene X diet interaction.Keywords: Cognition / aging / omega3 fatty acids / Apolipoprotein E gene / DHA Résumé -Acides gras oméga-3 à longue chaîne et cognition chez les sujets âgés : interaction avec le géno-type APOE. La recherche fondamentale et les études épidémiologiques suggèrent un effet protecteur des acides gras oméga3 à longue chaîne (AGPI-LC n-3) contre le déclin cognitif lié à l'âge. Cependant les études d'intervention avec des suppléments d'AGPI-LC n-3 ont donné des résultats décevants sur la cognition. Une raison pourrait en être un ciblage inadéquat des bénéficiaires potentiels d'une supplémentation en raison notamment de leur génotype pour le gène de l'Apolipoprotéine E (APOE). L'objectif de cet article était d'explorer l'effet potentiellement modificateur du géno-type de l'APOE sur le métabolisme des AGPI-LC n-3 et sa relation avec le déclin cognitif chez le sujet âgé. Au moins cinq études épidémiologiques et trois études d'intervention ont mis en évidence une interaction entre les AGPI-LC n-3 et le génotype de l'APOE sur la cognition des personnes âgées. Cependant la direction de l'effet est inconstant entre les études, certaines montrent un impact des AGPI-LC n-3 uniquement chez les porteurs de l'allèle epsilon4 (APOE4), principal facteur de risque génétique de maladie d'Alzheimer, et d'autres inversement un effet chez les non-porteurs de l'APOE4. Ces résultats discordants peuvent s'expliquer par des différences d'âge, de statut cognitif, de domaine d...

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Fish, docosahexaenoic acid and Alzheimer’s disease

Cited by 282 publications

References 182 publications

Adherence to a Mediterranean diet and onset of disability in older persons

Adherence to a Mediterranean diet and onset of disability in older persons

Lipid and Fatty Acids of Three Edible Myctophids, Diaphus watasei, Diaphus suborbitalis, and Benthosema pterotum: High Levels of Icosapentaenoic and Docosahexaenoic Acids

Long-chain omega3 polyunsaturated fatty acids and cognition in older people: interaction with APOE genotype

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