First world-wide interlaboratory study on polybrominated diphenylethers (PBDEs)

Boer, Jacob de; Cofino, W.P.

doi:10.1016/s0045-6535(01)00226-0

Cited by 115 publications

(79 citation statements)

References 8 publications

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“…In our preliminary experiment, BDE183 and BDE209 were difficult to combust in the oxidation tube. BDE209 can also thermally degrade when performing GC-MS analysis, especially when using a long capillary column [27]. Therefore, only lower brominated congeners were analyzed for stable carbon isotopic compositions.…”

Section: Application To Environmental Samplesmentioning

confidence: 99%

Method for the purification of polybrominated diphenyl ethers in sediment for compound-specific isotope analysis

Zeng¹,

Luo²,

Chen³

et al. 2013

Talanta

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Section: Application To Environmental Samplesmentioning

confidence: 99%

Method for the purification of polybrominated diphenyl ethers in sediment for compound-specific isotope analysis

Zeng¹,

Luo²,

Chen³

et al. 2013

Talanta

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“…Until now laboratories were not very experienced in this analysis. This is clearly reflected in results of inter-laboratory studies [6]. Methods for determination of PBDE-209 in environmental samples are based on extraction with organic solvents (hexane, toluene, hexane-acetone mixtures, or dichloromethane) or supercritical-fluid extraction (with CO 2 or CO 2 with modifiers such as methanol, acetone, and diethylamine) [7] and further clean-up by adsorption chromatography [8] or solid-phase extraction (SPE) [9].…”

Section: Introductionmentioning

confidence: 99%

Determination of decabromodiphenyl ether in sediments using selective pressurized liquid extraction followed by GC–NCI-MS

2003

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A method based on selective pressurized liquid extraction (SPLE) followed by gas chromatography-negative ion chemical ionization-mass spectrometry (GC-NCI-MS) has been evaluated for analysis of decabromodiphenyl ether (PBDE-209) in sediment samples. Instrumental operating conditions such as source temperature and system pressure were optimized in the NCI-MS system, giving an instrumental detection limit of 2 pg. The limit of determination of the entire SPLE-GC-NCI-MS procedure was around 50 pg g(-1) dry weight (dw), with repeatability of replicates between 4 and 21% relative standard deviation. Application of the method to 13 different river and marine sediment samples collected in Spain revealed that levels of decabromodiphenyl ether ranged between 2 and 132 ng g(-1) dry weight.

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“…Among the 209 possible congeners of PBDEs, the 2,2Ј,4,4Ј,5-brominated diphenyl ether (BDE-99) is one of the major isomers in penta-commercial products [De Boer and Cofino, 2002;Hardy, 2002]. Along with BDE-47 (a tetra-BDE), BDE-99 is found at high concentrations in biological tissues.…”

Section: Introductionmentioning

confidence: 99%

In vitro assessment of mutagenicity and clastogenicity of BDE‐99, a pentabrominated diphenyl ether flame retardant

Evandri

Mastrangelo

Costa

et al. 2003

Environ and Mol Mutagen

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Polybrominated diphenyl ethers (PBDEs), which are widely used as flame retardants, are considered persistent organic pollutants. To date, the available toxicological data on PBDEs are limited and were primarily obtained by studying technical blends. The present study was undertaken to investigate the genotoxicity of the pure congener 2,2',4,4',5-brominated diphenyl ether (BDE-99), one of the major isomers present in penta-commercial products. Bacterial reverse mutation assays in Salmonella typhimurium strains TA98 and TA100 and in Escherichia coli WP2 uvrA, and the Allium cepa chromosome aberration test were carried out to evaluate mutagenicity and clastogenicity. The experimental design also involved testing a well-known polychlorinated biphenyl (PCB) mixture, Aroclor(R) 1254, which is structurally related to PBDEs. BDE-99 was negative in the bacterial mutagenicity assays, with and without S9 mix. Also, the frequency of structural chromosome aberrations was not significantly higher than the control and no signs of cytotoxicity were observed in BDE-99-treated A. cepa. Aroclor(R) 1254 was not mutagenic, but it induced a significant increase in chromosomal aberrations in A. cepa. In conclusion, BDE-99 was not mutagenic in S. typhimurium or E. coli, or clastogenic in A. cepa; however, the possibility that PBDEs might act through an epigenetic mechanism cannot be excluded.

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First world-wide interlaboratory study on polybrominated diphenylethers (PBDEs)

Cited by 115 publications

References 8 publications

Method for the purification of polybrominated diphenyl ethers in sediment for compound-specific isotope analysis

Method for the purification of polybrominated diphenyl ethers in sediment for compound-specific isotope analysis

Determination of decabromodiphenyl ether in sediments using selective pressurized liquid extraction followed by GC–NCI-MS

In vitro assessment of mutagenicity and clastogenicity of BDE‐99, a pentabrominated diphenyl ether flame retardant

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