First-trimester prediction of preterm prelabour rupture of membranes incorporating cervical length measurement

Rode, Line; Wulff, C. B.; Ekelund, Charlotte Kvist; Hoseth, Eva; Petersen, Olav Bjørn; Tabor, Ann; El-Achi, Vanessa; Hyett, Jon; McLennan, Andrew

doi:10.1016/j.ejogrb.2023.03.003

Cited by 5 publications

(2 citation statements)

References 39 publications

(48 reference statements)

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“…The area under the curve for this model was reported at 0.72, indicating moderate predictive accuracy. Notably, this model was able to detect 30% of patients with pPROM while maintaining a false-positive detection rate of 10% 25 .…”

Section: Discussionmentioning

confidence: 90%

Evaluating the predictive efficacy of first trimester biochemical markers (PAPP-A, fβ-hCG) in forecasting preterm delivery incidences

Swiercz,

Zmelonek-Znamirowska,

Szwabowicz

et al. 2024

Sci Rep

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In this investigation, we explored the correlation between first-trimester biochemical markers and the incidence of preterm birth (PTB), irrespective of the cause, spontaneous preterm birth (sPTB), and preterm premature rupture of membranes (pPROM) within a cohort comprising 1164 patients. It was discovered that diminished levels of Pregnancy-Associated Plasma Protein-A (PAPP-A) between 11 and 13 + 6 weeks of gestation significantly contributed to the risk of preterm deliveries both before 35 and 37 weeks, as well as to pPROM instances. Furthermore, women experiencing sPTB before the 37th week of gestation also exhibited lower concentrations of PAPP-A. Moreover, reduced first-trimester concentrations of free beta-human chorionic gonadotropin (fb-HCG) were identified as a risk factor for deliveries preceding 37 weeks, pPROM, and sPTB before 35 weeks of gestation. Despite these correlations, the area under the curve for these biochemical markers did not surpass 0.7, indicating their limited diagnostic potential. The most significant discriminatory capability was noted for PAPP-A levels, with a threshold of < 0.71 multiples of the median (MoM) predicting PTB before 37 weeks, yielding an odds ratio of 3.11 (95% Confidence Interval [CI] 1.97–4.92). For sPTB, the greatest discriminatory potential was observed for PAPP-A < 0.688, providing an OR of 2.66 (95% CI 1.51–4.66). The cut-off points corresponded to accuracies of 76.05% and 79.1%, respectively. In regression analyses, the combined predictive models exhibited low explanatory power with R2 values of 9.2% for PTB and 7.7% for sPTB below 35 weeks of gestation. In conclusion, while certain biochemical markers demonstrated associations with outcomes of preterm birth, their individual and collective predictive efficacies for foreseeing such events were found to be suboptimal.

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Section: Discussionmentioning

confidence: 90%

Evaluating the predictive efficacy of first trimester biochemical markers (PAPP-A, fβ-hCG) in forecasting preterm delivery incidences

Swiercz,

Zmelonek-Znamirowska,

Szwabowicz

et al. 2024

Sci Rep

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“…Важно, что у женщин с ППСР во время комбинированного скрининга I триместра концентрации PAPP-A были ниже, а показатели пульсационного индекса маточных артерий, наоборот, выше по сравнению с теми, кто родил в срок [29]. Кроме того, при ППСР признаки нарушения кровообращения плацентарного ложа и физиологической трансформации миометриальных сегментов спиральных артерий по допплерометрии выявлялись чаще [28,30].…”

Section: современные методы прогнозирования поздних преждевременных с...unclassified

Late Premature Spontaneous Delivery: Versions and Contraversions

Apresyan,

Zyukina

2024

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Aim. To study modern ideas about late premature spontaneous labor, identify unresolved issues and identify tasks for further research on this theme. Key points. The problem of late premature labor occupies a leading position in modern obstetrics and perinatology. Currently, there is no single opinion and no identical approaches in predicting late premature spontaneous labor. This prevents the creation of a single algorithm of actions to prevent them. The article presents up-to-date information on the marker serum proteins and transcriptomic analysis of the placenta, as well as highlights some aspects of the pathogenesis of premature labor on the model of fetoplacental homeostasis disorders. Conclusion. To reduce the risk of adverse outcomes of late premature spontaneous labor, it is necessary to create clear criteria for their prediction and early diagnosis, as well as timely implementation of organizational and therapeutic measures for this obstetric complication. Keywords: late premature spontaneous labor, marker serum proteins, pregnancy-associated plasma protein-A, placental growth factor, soluble fms-like tyrosine kinase-1, gene expression.

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First-trimester and early-second-trimester transvaginal cervical length before 16 weeks among women with preterm and term birth: a systematic review and meta-analysis

Cheung,

Au,

et al. 2024

American Journal of Obstetrics & Gynecology MFM

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First-trimester prediction of preterm prelabour rupture of membranes incorporating cervical length measurement

Cited by 5 publications

References 39 publications

Evaluating the predictive efficacy of first trimester biochemical markers (PAPP-A, fβ-hCG) in forecasting preterm delivery incidences

Evaluating the predictive efficacy of first trimester biochemical markers (PAPP-A, fβ-hCG) in forecasting preterm delivery incidences

Late Premature Spontaneous Delivery: Versions and Contraversions

First-trimester and early-second-trimester transvaginal cervical length before 16 weeks among women with preterm and term birth: a systematic review and meta-analysis

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