First‐trimester maternal serum tumor necrosis factor receptor‐1 and pre‐eclampsia

Leal, Antonio; Poon, Liona C.; Frisová, V.; Veduță, Alina; Nicolaides, Kypros H.

doi:10.1002/uog.6275

Cited by 33 publications

(23 citation statements)

References 39 publications

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“…Although 65 combinations of markers included at least 1 marker that was assessed during the second trimester, only 6 combinations included both biological and ultrasonographic markers measured during the first trimester (32)(33)(34)(35)(36)(37). No given combination was assessed more than once.…”

Section: Discussionmentioning

confidence: 99%

“…When these variables were combined in logistic regression algorithms for early PE, a predictive rate of 94% at a false-positive rate of 5% was observed (35 ). Therefore, a growing body of evidence suggests that combination of first-trimester biochemical and ultrasonographic markers may be useful in prediction of early PE; the addition of maternal characteristics to the prediction algorithms might further improve their performance (33,(35)(36)(37). Although regression analysis demonstrated significant contribution to the detection or PE from maternal factors, TNF-R1, and PI, in multiple regression analysis, there was no significant contribution of TNF-R1 (P ϭ 0.07) to the prediction provided by maternal factors and PI (sensitivity 32%, specificity 95%).…”

Section: Discussionmentioning

confidence: 99%

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Combining Biochemical and Ultrasonographic Markers in Predicting Preeclampsia: A Systematic Review

et al. 2010

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BACKGROUND: Early identification of pregnant women at risk for preeclampsia is a priority to implement preventive measures. Some biochemical and ultrasonographic parameters have shown promising predictive performance, but so far there is no clinically validated screening procedure.CONTENT: Using a series of keywords, we reviewed electronic databases (Medline, Embase, all records to May 2009) reporting the performance of biological and ultrasonographic markers to predict preeclampsia, both single markers and combinations of markers. We analyzed the data according to gestational age and risk levels of the studied populations. We evaluated the methodological quality of included publications using QUADAS (quality assessment of diagnostic accuracy studies). We identified 37 relevant studies that assessed 71 different combinations of biochemical and ultrasonographic markers. Most studies were performed during the second trimester on small-scale high-risk populations with few cases of preeclampsia. Combinations of markers generally led to an increase in sensitivity and/or specificity compared with single markers. In low-risk populations, combinations including placental protein 13 (PP13), pregnancy-associated plasma protein A (PAPP-A), a disintegrin and metalloprotease-12 (ADAM12), activin A, or inhibin A measured in first or early second trimester and uterine artery Doppler in second trimester appear promising (sensitivity 60%-80%, specificity Ͼ80%). In high-risk populations, the combination of PP13 and pulsatility index in first tri-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combining Biochemical and Ultrasonographic Markers in Predicting Preeclampsia: A Systematic Review

et al. 2010

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“…Previous studies have shown that TNFreceptors are useful in first-trimester screening of women who are at subsequent risk of preeclampsia. 63,64 By contrast, elevated levels of TNF-R1 and TNF-R2 have been described as markers of normal human pregnancy, although a lack of soluble TNF-receptors have been associated with spontaneous miscarriage in women who undergo recurrent miscarriage. 65 In our study, there was significantly higher TNF-R1 levels in the plasma of patients with TM who had a normal pregnancy.…”

Section: Wwwajogorgmentioning

confidence: 99%

Pro- and antiinflammatory cytokines in threatened miscarriages

Calleja‐Agius

Muttukrishna

Pizzey

et al. 2011

American Journal of Obstetrics and Gynecology

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OBJECTIVE:The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome.STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF␣, interferon gamma (IFN␥), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS:Monocyte expression of TNF␣ and circulating levels of TNF␣, IFN␥, IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF␣/IL-10, IFN␥/IL-10, and TNF␣/IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome.CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage.

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“…While certain studies report increased TNF-α or TNF-R1 levels at as early as the first trimester in patients who subsequently develop preeclampsia, others reveal no significant difference between preeclampsic patients and controls (27,28). Leal et al found that maternal serum TNF-R1 levels at 11-13 weeks gestational age was increased in pregnant subjects developing preeclampsia, but the TNF-R1 levels were not associated with the degree of impairment in placental perfusion or the severity of preeclampsia (29). Our findings were consistent with the above-mentioned studies and supported the hypothesis that intravascular inflammation is a mechanism of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Serum protein microarray analysis of patients with preeclampsia

Hou

Zhu

et al. 2012

Mol Med Report

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Abstract. The present study identified novel factors related to preeclampsia. Serum samples were analyzed using a membrane-based human cytokine microarray technology in patients with preeclampsia. Serum was collected from 29 healthy pregnant subjects, 16 gestational hypertensive patients and 31 patients with preeclampsia. The samples for microarray analysis were randomly selected from 8 subjects, 5 patients with preeclampsia and 3 healthy pregnant controls. Serum was analyzed using a custom human cytokine microarray (RayBio ® Custom Human Cytokine Array) designed to analyze 120 specific cytokines simultaneously. The levels of sTNF-R1, Axl and TIMP-2 were further measured by sandwich enzyme-linked immunosorbent assay (ELISA). In microarray analysis, there were no significant differences in most of the measured parameters among the two study groups, except in serum TNF-R1, Axl and TIMP-2 (P=0.021, P=0.034 and P= 0.040, respectively). ELISA showed that the serum TNF-R1 levels were significantly higher in preeclampsia patients (288.06±78.30 pg/ml) compared to patients with gestational hypertension (229.81±47.65, P=0.005) and healthy pregnant subjects (247.48±59.00, P= 0.009). Serum Axl levels were markedly higher in patients with preeclampsia (2.28±0.25 ng/ml) compared to patients with gestational hypertension (2.05±0.21 ng/ml) and healthy pregnant subjects (2.11±0.28, P= 0.005). Additionally, preeclamptic patients had higher TIMP-2 levels (3.33±1.01 ng/ml) as compared to gestational hypertensive patients (3.13±0.56 ng/ml) and healthy pregnant women (3.00±0.49 ng/ml), but there was no pronounced difference between the three groups (F=1.285, P= 0.283>0.05). Our results demonstrated that two biological processes related to inflammatory response and endothelium activation are involved in the pathogenesis of preeclampsia.

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First‐trimester maternal serum tumor necrosis factor receptor‐1 and pre‐eclampsia

Abstract: Objectives To examine whether the maternal serum concentration of the soluble receptor-1 of tumor necrosis factor-α (TNF-R1

Cited by 33 publications

References 39 publications

Combining Biochemical and Ultrasonographic Markers in Predicting Preeclampsia: A Systematic Review

Combining Biochemical and Ultrasonographic Markers in Predicting Preeclampsia: A Systematic Review

Pro- and antiinflammatory cytokines in threatened miscarriages

Serum protein microarray analysis of patients with preeclampsia

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