First-Trimester Inflammatory Markers for Risk Evaluation of Pregnancy Hypertension

Sharma, Karuna; Singh, Ranju; Kumar, Manisha; Gupta, Usha; Rohil, Vishwajeet; Bhattacharjee, Jayashree

doi:10.1007/s13224-017-0988-1

Cited by 24 publications

(16 citation statements)

References 26 publications

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“…PE has multifactorial etiopathogenesis, including inflammation, 8 oxidative stress, 9 endothelial dysfunction, 10 disturbed balance between proangiogenic and antiangiogenic factors, 11 as well as inheritance 12 and dietary habits. 13 During the primary development of the placenta, extravillous trophoblasts (EVTs) of the fetal origin play an important role in the migration, invasion, and remodeling of the maternal spiral arteries in the myometrium and decidua.…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA 00473 Is Involved in Preeclampsia by LSD1 Binding-Regulated TFPI2 Transcription in Trophoblast Cells

Zou

et al. 2018

Molecular Therapy - Nucleic Acids

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Preeclampsia (PE) is a syndrome manifested by high blood pressure that could develop in the latter half of pregnancy; however, the underlying mechanisms are not understood. Recent evidence points to the function of noncoding RNAs (ncRNAs) as novel regulators of the invasion, migration, proliferation, and apoptosis of trophoblasts involved in the development of placental vasculature. Here, we investigated the role of long intergenic ncRNA 00473 (linc00473) in PE and the associated molecular mechanisms. The expression of linc00473 was downregulated in the placenta of patients with severe PE as revealed by qRT-PCR analysis. In vitro, linc00473 knockdown in trophoblast cell lines HTR-8/SVneo, JAR, and JEG3 significantly inhibited cell proliferation and promoted apoptosis, whereas linc00473 overexpression stimulated trophoblast proliferation. The mechanistic insights were provided by RNA-seq and qRT-PCR, which revealed that linc00473 could regulate the transcription of genes relevant to cell growth, migration, and apoptosis. In particular, linc00473 inhibited the expression of tissue factor pathway inhibitor 2 (TFPI2) through binding to lysine-specific demethylase 1 (LSD1). These results indicate that linc00473 could be involved in the pathogenesis and development of PE and may be a candidate biomarker as well as therapeutic target for this disease.

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Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA 00473 Is Involved in Preeclampsia by LSD1 Binding-Regulated TFPI2 Transcription in Trophoblast Cells

Zou

et al. 2018

Molecular Therapy - Nucleic Acids

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“…20,21 whereas a study done by Sharma et al shows the incidence of PE was more in multigravidae. 22 The risk of preeclampsia was more in obese patients, and the risk doubles with each 5 to 7 kg/m 2 increase in prepregnancy BMI. Obesity is associated with renal hyperfiltration, hyperperfusion, glomerular hypertrophy and diabetes-like changes including focal mesangial sclerosis or glomerular and tubular basement membrane thickening.…”

Section: Discussionmentioning

confidence: 96%

“…3 If untreated, pregnancy hypertension can progress to PE and eclampsia, which are life-threatening. 4 PE subdivided into early onset PE with delivery <34 weeks gestation, and late onset PE with delivery ≥34 weeks gestation. Early onset PE associated with higher incidence of adverse outcome.…”

Section: Introductionmentioning

confidence: 99%

Potential screening strategies for early prediction of pre-eclampsia

Hymavathi

Davuluru

Shaik

et al. 2021

Int J Reprod Contracept Obstet Gynecol

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Background: This study was conducted to evaluate the efficacy of different biochemical and biophysical markers in the early weeks of gestation as screening tools for early prediction of preeclampsia.Methods: This hospital-based prospective observational study conducted on 52 pregnant women, at less than 13 weeks of gestation were recruited. Maternal serum inhibin A and USG uterine artery PI levels were analyzed among the pregnant women who subsequently developed PE and compare with those who did not develop PE. Methods used for the detection of markers were: chemiluminescence immunoassay (CLIA) for serum inhibin A levels, and uterine artery Doppler velocimetry was done by PHILIPS HD11XE transabdominal ultrasound machine using a 4-6 MHz probe with the same sonographer.Results: The present study revealed a significant rise of inhibin A in preeclamptic women when compared to normotensive women (p<0.0001). The mean levels of 1st and 2nd trimester uterine artery PI significantly high in women who subsequently developed PE when compared to those who did not develop preeclampsia (p<0.0001). Study results showed a strong association between gestational age at delivery and neonatal outcome (neonatal birth weight and APGAR) with preeclampsia. The maternal serum inhibin A, and uterine artery PI found to have good sensitivity and specificity for early prediction of PE.Conclusions: Study concluded that the women who are prone to develop PE subsequently, had high levels of MAP, UAPI, inhibin A. In our setting, MAP, UAPI, inhibin A, appeared to be better screening modalities. Combination of the biochemical markers with the biophysical markers, demographic characteristics, and other novel markers will establish the effective screening models for early prediction of PE. Early identification of high-risk cases will offer an opportunity for prophylactic therapy, such as Low- dose Aspirin in selected groups of high-risk women screened in the first trimester, thus improving the maternal and perinatal outcome.

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“…Most tables of reference intervals for pregnant women focus on thyroid hormones [1][2][3], followed by blood routine [4,5] as well as others including pregnancy associated plasma protein-A (PAPP-A), free β-human chorionic gonadotropin, tumor necrosis factor-α (TNF-α) and interferon gamma (INF-γ) [6,7]. There are some sources that provide reference ranges or laboratory values for pregnant women in western countries [8][9][10][11] and there are several papers that provided them for pregnant women in some Asian populations [3][4][5]12].…”

Section: Introductionmentioning

confidence: 99%

New trimester-specific reference intervals for clinical biochemical tests in Taiwanese pregnant women-cohort of TMICS

et al. 2020

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Background Because there are no published biochemical reference intervals (RI) for pregnant Taiwanese women, we used an established islandwide birth cohort, the Taiwan Maternal and Infant Cohort Study, to establish RIs for important biochemical parameters in women during their 3rd trimester in Taiwan. Additionally, we compared the differences in these biochemical parameters between early third trimester (weeks 28 to 31) and late third trimester (weeks 37 to 40) of pregnant women as well as the differences in them between the third trimester and after delivery. Methods Between 2012 and 2015, we recruited a total of 2,136 pregnant women from nine hospitals located in northern (n = 3), central (n = 3), southern (n = 2), and eastern Taiwan (n = 1) to receive regular prenatal health examinations during their third trimester (weeks 28 to 40). After exclusion, samples obtained from 993 eligible pregnant women were analyzed. Results There were increases in both lower and upper normal limits for blood neutrophil, thyroid profile (triiodothyronine (T3) and thyroxine (T4)), testosterone, estradiol, and progesterone and decreases for RBC, hemoglobin (Hb), alanine aminotransferase (ALT) and creatinine (Cr) during their third trimesters. Women in their late third trimester (n = 378) had higher median RBC, Hb, aspartate aminotransferase (AST), Cr, thyroid-stimulating hormone (TSH), testosterone, estradiol, and progesterone and lower median platelet and insulin, compared with those in their early third trimester (n = 490). Twenty-three of the women had both third trimester and post-pregnancy data. After delivery, the women had lower median AST, ALT, insulin, T3, T4, testosterone, estradiol, and progesterone and higher median Cr, free T4, FSH, and luteinizing hormone (LH), compared to their third trimesters. Conclusions Gestation-related changes in important biochemical parameters should be considered when evaluating clinical laboratory values in pregnant women.

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First-Trimester Inflammatory Markers for Risk Evaluation of Pregnancy Hypertension

Cited by 24 publications

References 26 publications

Long Noncoding RNA 00473 Is Involved in Preeclampsia by LSD1 Binding-Regulated TFPI2 Transcription in Trophoblast Cells

Long Noncoding RNA 00473 Is Involved in Preeclampsia by LSD1 Binding-Regulated TFPI2 Transcription in Trophoblast Cells

Potential screening strategies for early prediction of pre-eclampsia

New trimester-specific reference intervals for clinical biochemical tests in Taiwanese pregnant women-cohort of TMICS

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