First total synthesis of neurotrophic diacetylene tetrol (−)-petrosiol D

Stereoselective total synthesis and structural revision of the diacetylenic diol natural products strongylodiols H and I

“…In continuation to our research interest on the synthesis of acetylenic compounds [ 19 – 21 ], recently we have accomplished the total synthesis of the diacetylenic polyol natural products petrosiols A, D, E ( 11 , 12 , 13 ) [ 22 – 23 ] and strongylodiols A–D ( 1 – 4 ) [ 24 ]. Herein we describe the total synthesis of strongylodiols H and I ( 9 and 10 ).…”

Total synthesis of (−)-petrosiol E

“…During our efforts, Srihari et al reported the first total synthesis of petrosiol D (4). 5 In their report, petrosiol D (4) was prepared from (þ)-diethyl L-tartrate with an overall yield of 4.7% in 17 steps, employing Sharpless asymmetric epoxidation, base-induced elimination of chiral epoxy halides, and CadioteChodkiewicz coupling …”