First total synthesis and structure confirmation of diacetylenic polyol (+)-oploxyne B

Srihari, P.; Reddy, A. Sathish; Yadav, J. S.; Yedlapudi, Deepthi; Kalivendi, Shasi V.

doi:10.1016/j.tetlet.2013.08.020

Cited by 10 publications

(1 citation statement)

References 25 publications

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“…Since then, more than 1000 acetylenic natural products have been isolated from organisms such as plants, mosses and lichens, fungi, bacteria, insects, algae, sponges, and tunicates with a variety of biological activities viz. anti-inflammatory, antimicrobial, antitumor, antiviral, neurotrophic, phytotoxic properties, etc. ,, Inspired by nature and enormous biological applications of acetylene moiety containing scaffolds, several synthetic or semisynthetic analogues or derivatives have been prepared. − The interesting and diverse activity of these compounds have been directly related to their linear rodlike conjugated structure. , Chart shows some of the prominent and biologically active acetylenic compounds found in nature (kingdom plantae and animalia both) as well as recently reported synthetic and semisynthetic acetylenic compounds. Acetylenic compounds found in higher plants can be classified into seven families, with the majority being isolated from the botanically related apiaceae, araliaceae, and asteraceae families.…”

Section: Applicationsmentioning

confidence: 99%

Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

et al. 2018

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Conjugated poly-ynes and poly(metalla-ynes) constitute an important class of new materials with potential application in various domains of science. The key factors responsible for the diverse usage of these materials is their intriguing and tunable chemical and photophysical properties. This review highlights fascinating advances made in the field of conjugated organic poly-ynes and poly(metalla-ynes) incorporating group 4-11 metals. This includes several important aspects of conjugated poly-ynes viz. synthetic protocols, bonding, electronic structure, nature of luminescence, structure-property relationships, diverse applications, and concluding remarks. Furthermore, we delineated the future directions and challenges in this particular area of research.

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Section: Applicationsmentioning

confidence: 99%

Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

et al. 2018

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Synthesis of Alkynyl Sulfides: Alkynyl Trifluoromethyl Sulfides and Thiocyanates

Zeng,

Yuan,

Jiao

et al. 2023

Eur J Org Chem

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Sulfur‐containing alkynes, are important starting materials and intermediates in organic reactions. Some of sulfur‐containing alkynes display interesting bioactivities and are potentially applied as drugs. Various synthetic methodologies towards sulfur‐containing alkynes have been developed, including C(sp)–S coupling, thiolation, S‐alkynylation, trifluoromethylthiolation, etc. In this review, the approaches towards alkynyl sulfides in recent 3 years, as well as to form alkynyl trifluoromethyl sulfides and alkynylthiocyanates were highlighted. Firstly, the property and application of alkynes were introduced. After presenting the superiority of sulfur‐containing alkynes, their synthetic methods were classified and presented in details. According to different kinds of sulfur‐containing alkynes, synthetic methodologies for alkynyl sulfides, alkynyl trifluoromethyl sulfides and alkynylthiocyanates were summarized and the proposed reaction mechanisms were demonstrated if available.

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Stereoselective Total Syntheses of (R )-Strongylodiols A, B, C and D

2017

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A facile stereoselective approach for the total syntheses of (R)strongylodiols A, B, C and D is described. A chiron approach has been followed wherein the stereochemistry at the chiral center is fixed and a methodology of base induced elimination of b-alkoxy chloride to get the chiral propargyl alcohol is employed. A key intermediate synthesized from commercially available (-)-diethyl D-tartrate has been utilized for the total syntheses of all the four titled compounds.

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First total synthesis and structure confirmation of diacetylenic polyol (+)-oploxyne B

Cited by 10 publications

References 25 publications

Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

Rise of Conjugated Poly-ynes and Poly(Metalla-ynes): From Design Through Synthesis to Structure–Property Relationships and Applications

Synthesis of Alkynyl Sulfides: Alkynyl Trifluoromethyl Sulfides and Thiocyanates

Stereoselective Total Syntheses of (R )-Strongylodiols A, B, C and D

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