“…Since then, more than 1000 acetylenic natural products have been isolated from organisms such as plants, mosses and lichens, fungi, bacteria, insects, algae, sponges, and tunicates with a variety of biological activities viz. anti-inflammatory, antimicrobial, antitumor, antiviral, neurotrophic, phytotoxic properties, etc. ,, Inspired by nature and enormous biological applications of acetylene moiety containing scaffolds, several synthetic or semisynthetic analogues or derivatives have been prepared. − The interesting and diverse activity of these compounds have been directly related to their linear rodlike conjugated structure. , Chart shows some of the prominent and biologically active acetylenic compounds found in nature (kingdom plantae and animalia both) as well as recently reported synthetic and semisynthetic acetylenic compounds. Acetylenic compounds found in higher plants can be classified into seven families, with the majority being isolated from the botanically related apiaceae, araliaceae, and asteraceae families.…”