First reported case of splenic diffuse red pulp small B-cell lymphoma with novel mutations in CXCR4 and TRAF3 genes

Zheng, Su-Ying; Li, Gang; Jin, Jing; Liu, Fang; Jiang, Wei; Feng, Yong; Zhang, Yaping; Luo, Hongqiang; Qin, Jiayue; Feng, Weiying

doi:10.1007/s12185-023-03581-3

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…Compared with SMZL, KLF2 mutations were rarely observed (2%), and TNF alpha induced protein 3 ( TNFAIP3) and MYD88 mutations were absent in SDRPL 49 . Other mutations in C‐X‐C motif chemokine receptor 4 ( CXCR4 ) and TNF receptor‐associated factor 3 (TRAF3) were more rarely observed 50 …”

Section: Hcl‐v/sblpn Is Very Close To Splenic Diffuse Red Pulp Lympho...mentioning

confidence: 99%

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Troussard,

Maitre

2023

J Cellular Molecular Medi

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The variant form of hairy cell leukaemia (HCL‐V) is a rare disease very different from hairy cell leukaemia (HCL), which is a very well‐defined entity. The 5th WHO edition (Leukemia, 36, 2022 and 1720) classification (WHO‐HAEM5) introduced splenic lymphomas/leukaemias including four different entities: (1) HCL, (2) splenic marginal zone lymphoma (SMZL) with circulating villous cells in the peripheral blood, (3) splenic lymphoma with prominent nucleolus (SLPN), which replaced HCL‐V and CD5 negative B‐prolymphocytic leukaemia (B‐PLL), and (4) splenic diffuse red pulp lymphoma (SDRPL). All these entities have to be distinguished because of a different clinical course and the need for a different treatment. The diagnosis can be challenging because of complex cases and overlap and/or grey zones between all the entities and needs integrating clinical, histologic, immunophenotypic, cytogenetic and molecular data. We review the diagnostic criteria including clinical, immunophenotypic and molecular characteristics of patients with HCL‐V and other HCL‐like disorders including HCL, SDRPL, SMZL, B‐PLL and the Japanese form of HCL. We also discuss the different criteria allowing us to separate these different entities and we will update the recent therapeutic options that have emerged, in particular the advances with chemoimmunotherapy and/or targeted therapies.

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Section: Hcl‐v/sblpn Is Very Close To Splenic Diffuse Red Pulp Lympho...mentioning

confidence: 99%

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Troussard,

Maitre

2023

J Cellular Molecular Medi

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Stem cell regulation and dynamics in myeloid malignancies

Sashida

2023

Int J Hematol

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First reported case of splenic diffuse red pulp small B-cell lymphoma with novel mutations in CXCR4 and TRAF3 genes

Cited by 2 publications

References 26 publications

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

Stem cell regulation and dynamics in myeloid malignancies

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