Stem cell regulation and dynamics in myeloid malignancies

Sashida, Goro

doi:10.1007/s12185-023-03615-w

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…OGT improves ASXL1 stability by inducing O -GlcNAcylation at the ASXL1 Ser199 site [ 127 ], while ASXL1 interacts with and activates BAP1 [ 66 ]. It is reported that ASXL1 is mutated in numerous myeloid malignancies, including MDS, AML, and CMML [ 128 , 129 ], and ASXL1 mutations have been shown to be positively associated with poor prognosis in patients with MDS and AML [ 130 , 131 ]. The ASXL1 mutation occurs at the C-terminus, generating a C-terminally truncated ASXL1 mutant [ 132 , 133 ], which retains the DEUBAD binding domain and facilitated the catalytic activity of BAP1 and promotes H2AK119ub1 deubiquitination, which in turn drives myeloid leukemogenesis [ 134 ].…”

Section: Pr-dub Complexmentioning

confidence: 99%

Can O-GIcNAc Transferase (OGT) Complex Be Used as a Target for the Treatment of Hematological Malignancies?

Zhuang,

Liu,

et al. 2024

Pharmaceuticals

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The circulatory system is a closed conduit system throughout the body and consists of two parts as follows: the cardiovascular system and the lymphatic system. Hematological malignancies usually grow and multiply in the circulatory system, directly or indirectly affecting its function. These malignancies include multiple myeloma, leukemia, and lymphoma. O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) regulates the function and stability of substrate proteins through O-GlcNAc modification. Abnormally expressed OGT is strongly associated with tumorigenesis, including hematological malignancies, colorectal cancer, liver cancer, breast cancer, and prostate cancer. In cells, OGT can assemble with a variety of proteins to form complexes to exercise related biological functions, such as OGT/HCF-1, OGT/TET, NSL, and then regulate glucose metabolism, gene transcription, cell proliferation, and other biological processes, thus affecting the development of hematological malignancies. This review summarizes the complexes involved in the assembly of OGT in cells and the role of related OGT complexes in hematological malignancies. Unraveling the complex network regulated by the OGT complex will facilitate a better understanding of hematologic malignancy development and progression.

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