First reported case of Robinsoniella peoriensis pyometra and bloodstream infection: A case report and review of the literature

Mejia-Gomez, Javier; Zigras, Tiffany; Patel, Yashesh; Wolfman, Wendy; Philippopoulos, Eleni; Shaltout, Nada; Rotstein, Coleman; Laframboise, Stéphane; Patel, Samir N.; Kus, Julianne V.; Poutanen, Susan M.; Hosseini-Moghaddam, Seyed M

doi:10.1016/j.anaerobe.2022.102581

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…32 In 2022, eight months after a prematurely terminated surgery, a Canadian woman with jejunal adenocarcinoma and endometrial cancer was admitted to hospital and analysis of blood and uterine samples revealed a Clostridium perfringens infection. 33 A course of piperacillin-tazobactam, tobramycin and doxycycline was initiated for four days with resolution. Next, she was put on oral amoxicillin-clavulanate for ve weeks.…”

Section: Discussionmentioning

confidence: 99%

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

Hunter,

Dia,

Boykins

et al. 2024

Preprint

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Pancreatic cancer is a significant public health concern, with increasing incidence rates and limited treatment options. Recent studies have highlighted the role of the human microbiome, particularly the gut microbiota, in the development and progression of this disease. Microbial dysbiosis, characterized by alterations in the composition and function of the gut microbiota, has been implicated in pancreatic carcinogenesis through mechanisms involving chronic inflammation, immune dysregulation, and metabolic disturbances. Researchers have identified specific microbial signatures associated with pancreatic cancer, offering potential biomarkers for early detection and prognostication. By leveraging advanced sequencing and bioinformatics tools, scientists have delineated differences in the gut microbiota between pancreatic cancer patients and healthy individuals, providing insights into disease pathogenesis and potential diagnostic strategies. Moreover, the microbiome holds promise as a therapeutic target in pancreatic cancer treatment. Interventions aimed at modulating the microbiome, such as probiotics, prebiotics, and fecal microbiota transplantation, have demonstrated potential in enhancing the efficacy of existing cancer therapies, including chemotherapy and immunotherapy. These approaches can influence immune responses, alter tumor microenvironments, and sensitize tumors to treatment, offering new avenues for improving patient outcomes and overcoming therapeutic resistance. Overall, understanding the complex interplay between the microbiome and pancreatic cancer is crucial for advancing our knowledge of disease mechanisms and identifying innovative therapeutic strategies. Here we report phylogenetic analysis of the 16S microbial sequences of the pancreatic cancer mice microbiome and corresponding age matched healthy mice microbiome. We successfully identified differentially abundance of microbiota in the pancreatic cancer.

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Section: Discussionmentioning

confidence: 99%

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

Hunter,

Dia,

Boykins

et al. 2024

Preprint

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“…In contrast, the remaining three bacteria showed a tendency to increase in nontreated and treated‐tumor‐bearing mice that did not receive oral probiotics (Figure 3B). One strain of Robinsoniella was identified in 2009 as a Gram‐positive, spore‐forming, anaerobic rod that was originally isolated from swine manure and can cause lethal septic shock in patients with cancer 37 . To date, there is limited or no evidence regarding the association between cancer progression and treatment with Robinsoniella , Merdimonas , and Phocea species.…”

Section: Discussionmentioning

confidence: 99%

Probiotics enhances anti‐tumor immune response induced by gemcitabine plus cisplatin chemotherapy for urothelial cancer

et al. 2022

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Chemotherapy drugs, such as gemcitabine and cisplatin (GC), are frequently administered to patients with advanced urothelial carcinoma, however the influence of the gut microbiota on their action is unclear. Thus, we investigated the effects of GC on the gut microbiome and determined whether oral supplementation with a probiotics mixture of Lactobacillus casei Shirota and Bifidobacterium breve enhanced the anti-tumor immune response. After subcutaneous inoculation with MBT2 murine bladder cancer cells, syngenic C3H mice were randomly allocated into eight groups.The gut microbiome cluster pattern was altered in both the GC and oral probiotics groups (p = 0.025). Both tumor-bearing conditions (no treatment) and GC chemotherapy influenced Pseudoclostridium, Robinsoniella, Merdimonas, and Phocea in the gut. Furthermore, comparison of the GC-treated and GC + probiotics groups revealed an association of four methyltransferase family enzymes and two short-change fatty acid-related enzymes with oral probiotics use. A significant difference in tumor volume was observed between the GC and GC + probiotics groups at week 2 of treatment. Additionally, decreased recruitment of cancer-associated fibroblasts and regulatory T cells, and activation of CD8 + T cells and dendritic cells were observed in the tumor microenvironment. Our findings reveal the positive effects of a probiotics mixture of Lactobacillus and Bifidobacterium in enhancing anti-tumor effects through the gut-tumor immune response axis. Future clinical trials are needed to evaluate the full benefits of this novel supplement with oral probiotics in patients with advanced urothelial carcinoma.

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Robinsoniella peoriensis: an emerging pathogen with few virulence factors

McLaughlin

2022

Int Microbiol

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First reported case of Robinsoniella peoriensis pyometra and bloodstream infection: A case report and review of the literature

Cited by 5 publications

References 19 publications

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

An investigation for phylogenetic characterization of human Pancreatic cancer microbiome by 16SrDNA Sequencing and Bioinformatics techniques

Probiotics enhances anti‐tumor immune response induced by gemcitabine plus cisplatin chemotherapy for urothelial cancer

Robinsoniella peoriensis: an emerging pathogen with few virulence factors

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