Robinsoniella peoriensis: an emerging pathogen with few virulence factors

McLaughlin, Richard William

doi:10.1007/s10123-022-00281-6

Cited by 1 publication

(3 citation statements)

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“…To that end, these predisposing factors are included as a minor criterion in the diagnostic criteria for the diagnosis of infective endocarditis even after the last updates of the criteria [40]. Figure 4 summarizes the possible pathogenicity of R. peoriensis based on the currently described virulence factors and types of infections [6]. The polymicrobial infection was relatively common in patients with an infection by R. peoriensis.…”

Section: Discussionmentioning

confidence: 99%

“…Notably, even though data regarding the antimicrobial susceptibility of R. peoriensis have been provided in the case reports included in the present analysis, the mechanisms underlying this resistance remain unknown. Interestingly, no genes associated with antimicrobial resistance were identified by McLaughlin in his recent study on the pathogenicity of R. peoriensis [ 6 ]. Given that in the present review, there was notable antimicrobial resistance to some antimicrobials, the fact that no known gene associated with antimicrobial resistance was identified may imply that either the strains studied by McLaughlin would have been sensitive if tested with antimicrobial susceptibility assays, while the resistant clinical strains may have some of the known antimicrobial resistant genes, or that the resistant clinical isolates may harbor genes conferring resistance by unknown mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…For example, in a recent study, McLaughlin characterized the pathogenicity of R. peoriensis using a pathogenomics approach. More specifically, six strains were used and allowed the conduction of the phylogenetic analysis and the identification of specific prophages inside their genome, while issues regarding its antimicrobial resistance and putative virulence factors were discussed [6]. In other studies, R. peoriensis has been Antibiotics 2024, 13, 570 2 of 13 identified in humans and animals, and, in some cases, its genome was characterized [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Robinsoniella peoriensis Infections in Humans—A Narrative Review

Ioannou,

Baliou,

Kofteridis

2024

Antibiotics

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Robinsoniella peoriensis is a Gram-positive, strictly anaerobic, spore-forming, rod-shaped bacterium belonging to the phylum Firmicutes and the family Lachnospiraceae. Until now, R. peoriensis is the only species of its genus. It was first isolated in 2003 during a study into the flora of lagoons and manure pits. Given the rarity of this microorganism and the sparse information in the literature about its way of transmission, the way to diagnose its infections and identify it in the microbiology laboratory, and its public health relevance, the present study aimed to identify all the published cases of Robinsoniella, describe the epidemiological, clinical, and microbiological characteristics, and provide information about its antimicrobial resistance, treatment, and outcomes. A narrative review was performed based on a Pubmed/Medline and Scopus databases search. In total, 14 studies provided data on 17 patients with infections by Robinsoniella. The median age of patients was 63 years and 47% were male. The most common types of infection were bone and joint infections, bacteremia, infective endocarditis, and peritonitis. The only isolated species was R. peoriensis, and antimicrobial resistance to clindamycin was 50%, but was 0% to the combination of piperacillin with tazobactam, aminopenicillin with a beta-lactamase inhibitor, and metronidazole which were the most commonly used antimicrobials for the treatment of these infections. The overall mortality depends on the type of infection and is notable only for bacteremia, while all other infections had an optimal outcome. Future studies should better assess these infections’ clinical and epidemiological characteristics and the mechanisms of the antimicrobial resistance of this microorganism from a mechanistic and genetic perspective.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%