First report on isolation of 2,3,4-trihydroxy-5-methylacetophenone from palmyra palm ( Borassus flabellifer Linn.) syrup, its antioxidant and antimicrobial properties

Reshma, M.V.; Jacob, Jubi; Syamnath, V.L.; Habeeba, V.P.; Kumar, Bhuvnesh; Lankalapalli, Ravi S.

doi:10.1016/j.foodchem.2017.02.043

Cited by 19 publications

(13 citation statements)

References 14 publications

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“…2,3,4-trihydroxy-5-methylacetophenone obtained from palmyra palm ( Borassus flabellifer Linn.) showed potential antimycobacterial activity against M. smegmatis with MIC of 10.0 µg/mL [ 154 ]. Another study in 2014 showed that total flavonoid contents obtained from fourteen edible plants possess a potent antioxidant (IC 50 values of DPPH: 8.15 μg/mL; ABTS: 9.16 μg/mL and TEAC: 0.75), antimycobacterial ( M. smegmatis and M. fortuitum : MIC value of 78 μg/mL) and the cytotoxic activities (LC 50 values stretching from 33 to 102 μg/mL) [ 155 ].…”

Section: Anti-nontuberculous Mycobacterial Efficacy and Mechanismsmentioning

confidence: 99%

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

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Nontuberculous mycobacteria (NTM) are the causative agent of severe chronic pulmonary diseases and is accountable for post-traumatic wound infections, lymphadenitis, endometritis, cutaneous, eye infections and disseminated diseases. These infections are extremely challenging to treat due to multidrug resistance, which encompasses the classical and existing antituberculosis agents. Hence, current studies are aimed to appraise the antimycobacterial activity of flavonoids against NTM, their capacity to synergize with pharmacological agents and their ability to block virulence. Flavonoids have potential antimycobacterial effects at minor quantities by themselves or in synergistic combinations. A cocktail of flavonoids used with existing antimycobacterial agents is a strategy to lessen side effects. The present review focuses on recent studies on naturally occurring flavonoids and their antimycobacterial effects, underlying mechanisms and synergistic effects in a cocktail with traditional agents.

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Section: Anti-nontuberculous Mycobacterial Efficacy and Mechanismsmentioning

confidence: 99%

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

2020

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“…The dose‐dependent increase in percentage neutrophil adhesion of treatment groups could be explained on the basis of phytochemicals present in the TS and PPS. Our previous study on PPS revealed the presence of 2,3,4‐trihydroxy‐5‐methylacetophenone, which has exhibited strong antimicrobial activity (Reshma et al., 2017).…”

Section: Resultsmentioning

confidence: 99%

“…Adhesion of mature neutrophils on to nylon fibers provides insights into the status of the immune system that deals with fighting microbial infection (Benacerraf, 1978). Our previous study on PPS revealed the presence of 2,3,4-trihydroxy-5-methylacetophenone, which has exhibited strong antimicrobial activity (Reshma et al, 2017).…”

Section: Neutrophil Adhesion Testmentioning

confidence: 99%

“…along with a decoction of these three spices exhibit immunomodulatory properties. The Palmyra Palm yields an oyster colored sap with a brix (Bx) ranging from 10–15°Bx; this sap is processed into syrup by open pan evaporation (Reshma et al., 2017). The product referred in this study as ‘Trikatu syrup’ (TS) was compared with the control Palmyra Palm syrup (PPS).…”

Section: Introductionmentioning

confidence: 99%

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Spice‐infused palmyra palm syrup improved cell‐mediated immunity in Wistar Albino rats

et al. 2020

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Spices attract tremendous attention in the management of viral infections. However, scientific validation is vital to recommend spices as nutraceuticals or functional foods. In the present work, we have selected three spices based on Ayurvedic knowledge and developed a nutraceutical for immunomodulation. Trikatu, a blend of ginger, black pepper, and long pepper, is used in the Indian Ayurvedic system, along with many herbs, for various ailments. We formulated a "Trikatu syrup" (TS) using these three spices and palmyra palm neera. Carbon clearance assay, neutrophil adhesion test, and sheep red blood cell (SRBC)-induced delayed-type hypersensitivity (DTH) reaction was performed to investigate the immunomodulatory potential of TS in Wistar Albino rats. The rats fed with TS showed a dose-dependent increase in footpad thickness compared to control rats, suggesting cell-mediated immunity. The major bioactive piperine in TS was isolated and quantified. Practical applications Spices are consumed worldwide as a flavor enhancer in food. Besides, spices have an array of bioactive molecules with a multitude of health benefits. In the backdrop of COVID-19, immunomodulation and antiviral properties of spices are discussed widely. The present study is intended to explore the potential of three selected spices (ginger, black pepper, and long pepper) beyond its application in typical food preparations. The syrup formulated in this study by using these three spices improved cell-mediated immunity in Wistar Albino rats. The study warrants further validation studies of the formulated product for providing indisputable claims for the immunomodulation properties.

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“…al. [8] has successfully extract 2,3,4-trihydroxy-5-methylacetophenone, nicotinamide, and uracil of palmyra palm syrup by using chloroform and butanol. The 2,3,4-trihydroxy-5-methylacetophenone is exhibited DPPH radical scavenging activity that used as antibacterial against Escherichia coli, Staphylococcus aureus, Mycobacterium smegmatis, and Staphylococcus simulans.…”

Section: Borassus Flabellifermentioning

confidence: 99%

Palm Sap Sources, Characteristics, and Utilization in Indonesia

Kurniawan¹,

Jayanudin²,

Kustiningsih³

et al. 2018

JFNR

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Sap from various species palm trees in which known as neera generally produced by traditional technology in Indonesia. There are 5 well known palm species that produce Neera in Indonesia such as arenga palm, coconut tree, doub palm, nipa palm and palm oil. Neera can be utilized as raw material for various derivatives such as palm sugar, sweet palm toddy, and alcoholic toddy. Tapping of neera is a crucial step because neera prone to immediately degrade and causing poor quality of palm sugar. Traditional sugar processing has some drawbacks for example: low energy efficiency processing and off-specification products. On the other side, sugar palm neera has important antioxidant component which benefits for human that unavailable in normal white sugar from sugarcane. In this current review, characterization of neera from various palms in Indonesia and available technology on sugar palm processing such as spray dryer and membrane ultrafiltration will be discussed.

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First report on isolation of 2,3,4-trihydroxy-5-methylacetophenone from palmyra palm ( Borassus flabellifer Linn.) syrup, its antioxidant and antimicrobial properties

Cited by 19 publications

References 14 publications

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria

Spice‐infused palmyra palm syrup improved cell‐mediated immunity in Wistar Albino rats

Palm Sap Sources, Characteristics, and Utilization in Indonesia

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