First report of the main vector of visceral leishmaniasis in America, <i>Lutzomyia longipalpis</i>
 (Lutz, Neiva, 1912) (Diptera: Psychodidae: Phlebotominae), in southern Minas Gerais State, Brazil

Barçante, Thales Augusto; Botelho, Maria C.A.; Freitas, Heloísa F.; Soares, Gustavo D.T.; Barçante, J. M. P.

doi:10.1111/jvec.12182

Cited by 3 publications

(7 citation statements)

References 7 publications

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“…Health education is considered an important tool in controlling leishmaniasis 13 . Of note, the delay and failure in the early diagnosis leading to health worsening, often evidence the negligence of the disease by health professionals 12 , 14 , 15 . In the present case, 20 days have passed since the appearance of the first symptoms until the definitive diagnosis.…”

Section: Discussionmentioning

confidence: 64%

“…Therefore, it is of great clinical importance that health professionals be familiar with the clinical patterns of VL to avoid delayed or missed diagnosis 11 . Since the first confirmed case of canine VL in 2013, and the first report of Lutzomyia longipalpis in the municipality of Lavras in 2015 12 , several health education actions were implemented by the authors, who were aware of the importance of the disease and the early diagnosis and treatment. These actions were applied to health professionals, teachers of elementary and secondary education schools and throughout the community by the distribution of explanatory brochures, flipcharts, and lectures.…”

Section: Discussionmentioning

confidence: 99%

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First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Narciso

Carvalho

Campos³

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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American visceral leishmaniasis (VL) is a vector-borne disease transmitted by some species of phlebotomine sandflies from the genus Lutzomyia. This neglected tropical zoonosis shows increasing urbanization process, since the end of the 1980s. After the emergence of foci of the disease in urban areas, VL has assumed an important role in public health. Although VL is widely prevalent in several parts of the world, diagnosing the illness is still difficult. We present a case of a 12-year-old girl with a history of recurrent fever, anorexia, cachexia, chronic fatigue, weight loss, left palpebral unilateral edema, persistent cough and pancytopenia. A diagnosis of VL was performed using a reference immunochromatographic rapid test. Identification of the infecting protozoan was directly obtained by PCR of bone marrow. The patient responded favorably to treatment using liposomal amphotericin B. This is the first report of human visceral leishmaniasis in the city of Lavras in the South of Minas Gerais State. This first report of VL highlighted the need of maintenance of permanent surveillance and control programs in the city of Lavras, including the active search of sandflies, human and canine cases. The current situation of Lavras should also be taken as an alert to other near cities where favorable eco-epidemiological conditions may exist.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Narciso

Carvalho

Campos³

et al. 2018

Rev. Inst. Med. trop. S. Paulo

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“…A phlebotominic survey was performed, but Lutzomyia -carrying insects were not found in this municipality 39 , 40 . In the city of Lavras (21°14'S, 44°59'W, about 140 km from Alfenas ), in an area of raising chicks 20 , specimens of L. longipalpis were found as well as dogs diagnosed with CVL. Cases of CVL have also been reported in another study carried out in Juiz de Fora 19 (21°14' S, 42°14'W, about 380 km from Alfenas and 240 km from Lavras ), another city of the southern region of Minas Gerais , close to Rio de Janeiro State.…”

Section: Discussionmentioning

confidence: 96%

“…In 1989, the death of a two-year-old child from VL was reported in Belo Horizonte , the capital of the state 15 , and in the same study, the presence of infected dogs and of the vector L. longipalpis was verified in various districts of the city. Other cases were described in Governador Valadares 16 , Montes Claros 17 and Divinópolis 18 , municipalities in the northern region of the state, and in Juiz de Fora 19 and Lavras 20 , located in the southern region of the state. Currently, the region of Belo Horizonte , the state capital, has the highest incidence of VL and the higher risk of disease transmission 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%

Leishmania infantum INFECTION IN DOGS FROM THE SOUTHERN REGION OF MINAS GERAIS STATE, BRAZIL

Nunes

Laurenti

Kanamura

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVisceral leishmaniasis is a systemic and chronic disease and dogs are the main reservoir of the etiologic agent, Leishmania infantum (syn L. chagasi). A serological and molecular investigation of canine visceral leishmaniasis (CVL) was performed in the municipality of Alfenas, located in the southern region of Minas Gerais, where the disease is not endemic. Samples from 87 dogs were submitted to serological tests including the Dual Path Platform (DPP(r) ) CVL Bio-Manguinhos rapid test, an in-house enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence antibody test (IFAT), as well as molecular techniques such as a conventional polymerase chain reaction (PCR) with the RV1/RV2 primers and a quantitative PCR (qPCR) with the LinJ31, Ldon and DNApol primers. Of the 87 serum samples, eight (9.2%) were positive for Leishmania using the DPP rapid test, but only four (4.6%) were confirmed by ELISA and two (2.3%) by IFAT. In these two serologically confirmed cases, spleen and liver samples were positive by all the employed molecular and parasitological procedures performed on spleen samples. When whole blood samples were used in the molecular assays, two samples (2.3%) were positive only by qPCR. DNA extracted and amplified from the spleens of seropositive dogs was sequenced, showing 100% of similarity with the Leishmania infantum (syn L. chagasi) sequence. Thus, the first cases of CVL have been confirmed in the Alfenas region, suggesting the importance of canine surveys in non-endemic municipalities for CVL to monitor disease progression and to prevent outbreaks.

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“…Leishmaniasis is an infectious and parasitic disease with a variety of clinical forms, ranging from dermatological lesions (tegumentary leishmaniasis) to systemic manifestations (visceral leishmaniasis). 1-4 American tegumentary leishmaniasis (ATL) represents a serious public health problem. Due to the high number of cases of ATL in Brazil, differential diagnosis is necessary to understand the epidemiological profile of ATL, both in areas previously considered non-endemic and in endemic areas.…”

mentioning

confidence: 99%

Use of the polymerase chain reaction for the diagnosis of American tegumentary leishmaniasis

Barçante

Souza

Fernandes

et al. 2019

An. Bras. Dermatol.

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First report of the main vector of visceral leishmaniasis in America, Lutzomyia longipalpis (Lutz, Neiva, 1912) (Diptera: Psychodidae: Phlebotominae), in southern Minas Gerais State, Brazil

Cited by 3 publications

References 7 publications

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

First report of an autochthonous human visceral leishmaniasis in a child from the South of Minas Gerais State, Brazil

Leishmania infantum INFECTION IN DOGS FROM THE SOUTHERN REGION OF MINAS GERAIS STATE, BRAZIL

Use of the polymerase chain reaction for the diagnosis of American tegumentary leishmaniasis

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