First report of invasive <i>Aspergillus</i> rhinosinusitis in a critically ill COVID‐19 patient affected by acute myeloid leukemia, northeastern Iran

Hosseinikargar, Neginsadat; Basiri, Reza; Asadzadeh, Mohammad; Najafzadeh, Mohammad Javad; Zarrinfar, Hossein

doi:10.1002/ccr3.4889

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…Chronic conditions and other comorbidities have been reported in many cases of candidemia [20,21]. The relationship between DM and candidemia has been studied several times, especially since patients with DM are more sensitive to fungal infections than those without DM [22,23]. There are a few components in the pathogenesis of candidemia in patients with DM, especially Candida colonization, which is more common in patients with diabetes than in patients without DM.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Dursun¹,

Sipahioğlu²,

Yüksel³

et al. 2022

CMM

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Background and Purpose: Candidemia remained important in the intensive care units (ICU) during the COVID-19 pandemic. This study aimed to investigate the clinical and laboratory data on candidemia in COVID-19 patients. Materials and Methods: The baseline characteristics, as well as laboratory and clinical findings of candidemia and non-candidemia patients, were compared. Candidemia was defined as the isolation of Candida spp. from blood cultures. The isolates were identified by VITEK® 2 (bioMérieux, France) commercial method. Antifungal susceptibility was assessed using the E-test method. Univariate and multiple binary logistic regression analyses were performed to compare the variables. Results: In total, 126 patients with the COVID-19 disease were included. Candidemia was diagnosed in 44 (35%) of the patients. The number of patients with diabetes mellitus and chronic renal failure was higher in the candidemia group. In the candidemia group, the duration of ICU stay of patients, the 30-day mortality rate, mechanical ventilation therapy, and systemic corticosteroids (Prednisone) usage were significantly higher in candidemia patients. Moreover, the median white blood cell, neutrophils, and lactate dehydrogenase were higher in the candidemia group. Univariate and multiple binary logistic regression analyses were performed to compare the variables. Isolated species were identified as Candida albicans (n=12, 41%), Candida parapsilosis (n=7, 24%), Candida glabrata (n=6, 21%), Candida tropicalis (n=3, 10%), and Candida dublinensis (n=1, 3%). In total, three isolates of six C. glabrata species had dose-dependent sensitivity to fluconazole, and one C. parapsilosis was determined to be resistant. Conclusion: The COVID-19 patients who are admitted to ICU have many risk factors associated with candidemia. The most common risk factors for the development of candidemia were mechanical ventilation, diabetes mellitus, neutrophilia, and low hemoglobin level. The most frequently isolated species was C. albicans. Moreover, caspofungin was found to be the most effective drug in vitro. No significant resistance pattern was detected against the isolated species. It should be noted that risk-stratified antifungal prophylaxis in the ICU is possible.

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Section: Discussionmentioning

confidence: 99%

Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Dursun¹,

Sipahioğlu²,

Yüksel³

et al. 2022

CMM

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“…Indoor air of hospital wards could have a wide range of infectious microorganisms. Exposure to airborne microbes may have a more severe effect on susceptible groups, especially those who are immunocompromised [ 7 ]. Fungal agents are one of the most common microorganisms in hospital indoor environments, which can lead to nosocomial infections.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to many microorganisms is inevitable in indoor environments such as hospitals [ 5 ]. It can be hazardous for hospitalized patients, especially those requiring long-term intensive care to exposure under the bioaerosols [ 6 , 7 ]. Fungi are considered as one of the major sources of microbial contamination in indoor environments [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…Also, outdoor fungal spores may be transmitted through visitors, patients, and air conditioning [ 8 ]. Opportunistic fungal infections are usually reported in individuals with immune deficiency, such as hospitalized patients [ 7 ]. Therefore, fungal bioaerosols should be reduced in hospitals because of the high-risk groups; those may be sensitive or vulnerable to these dangerous biological agents [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Interventional Effect of Nanosilver Paint on Fungal Load of Indoor Air in a Hospital Ward

Rostami

Hossein

Zarrinfar

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Hospital ward environments contain various types of microorganisms, in which fungal agents are one of the main contaminants that may cause hospital-acquired infections. Regarding this, the aim of the present study was to evaluate the effect of nanosilver paint on reducing fungal contaminants of indoor air in an educational, research, and treatment center. Two rooms in the hematology ward were selected. One room was painted using usual paint (control room) and the other room was painted with paint containing nanosilver particles (experimental room). One hundred and twelve samples were collected using active (Anderson BioSampler) and passive (settle plate or open plate) air sampling techniques. The samples were incubated for 3–7 days at 35°C, and the positive fungal cultures were examined according to morphological and microscopic characteristics. Following active sampling, the mean and standard deviation of the number of colony-forming units (CFU/m3) of fungi colonies in the experimental and control rooms were 29.21 ± 17.99 and 22.50 ± 10.02 before intervention and 13.79 ± 6.20 and 31.07 ± 21.1 after intervention, respectively. Following passive sampling, the number of CFU/plate in the experimental and control rooms was 6 and 0 before and 1and 1 after intervention, respectively. The use of the nanosilver paint was effective in reducing air fungal contamination. Moreover, the active sampling method was more sensitive to measuring the concentration changes for fungal bioaerosols.

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“…Although C. albicans is still the most common species, the infection rate of non- C. albicans spp. has increased significantly in recent decades, especially in ICU patients ( 5 – 7 ). According to an epidemiological study conducted in Europe, the mortality rate of patients with non- C.albicans infections is higher than that of patients with C. albicans infections (47.3 and 32.4%, respectively) ( 8 , 9 ).…”

Section: Introductionmentioning

confidence: 99%

Deep Fungal Infections Among General Hospital Inpatients in Southwestern China: A 5-Year Retrospective Study

Wen

Yang

Dong

et al. 2022

Front. Public Health

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BackgroundDeep fungal infection is a type of life-threatening opportunistic infection. Its incidence has been increasing in recent years. This infection can affect the prognosis of patients, prolong hospital stays and raise costs for patients and their families.ObjectiveWe aimed to understand the current situation of deep fungal infections in the First Affiliated Hospital of Kunming Medical University and to provide a basis for the clinical diagnosis and treatment of deep fungal infections.MethodsThis was a retrospective analysis of 528,743 cases in the hospital from 2015 to 2019, including the epidemiological characteristics, treatment and prognosis of deep fungal infections.ResultsA total of 274 cases (0.05%) with deep fungal infections were identified, accounting for 0.05% of the total number of hospitalizations. The incidence of deep fungal infections in the hospital showed an increasing trend from 2015 to 2019. The most commonly infected site was the respiratory tract (93.07%). Among patients with deep fungal infections, 266 specimens were positive for fungal culture, by which 161 cultured Candida albicans (C. albicans), accounting for 60.53%, the main pathogen causing deep fungal infection. From 2015 to 2019, the percentage of C. albicans cases showed a downward trend, while that of non-C. albicans showed an opposite trend. Antibiotics were the most common predisposing factor for deep fungal infections (97.45%). Among the underlying diseases of patients with deep fungal infections, infectious diseases (59.49%) were the most common. Those with underlying diseases such as renal insufficiency and neurological diseases had a worse prognosis. Indwelling catheters, nervous system disease and tumors were risk factors for a poor prognosis.ConclusionsWe report for the first time the epidemiological data of deep fungal infections in a general hospital in southwestern China from 2015 to 2019. In the past 5 years, the number of patients with deep fungal infections in the First Affiliated Hospital of Kunming Medical University has been increasing. Although the clinical data are limited, these results can provide references for the diagnosis and treatment of deep fungal infections.

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First report of invasive Aspergillus rhinosinusitis in a critically ill COVID‐19 patient affected by acute myeloid leukemia, northeastern Iran

Abstract: This is a report of established invasive Aspergillus rhinosinusitis in a patient diagnosed with COVID‐19 and afflicted by AML, which was initially considered to be rhinocerebral mucormycosis.

Cited by 12 publications

References 17 publications

Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Risk factors and lethality associated with Candidemia in severe COVID-19 patients

Interventional Effect of Nanosilver Paint on Fungal Load of Indoor Air in a Hospital Ward

Deep Fungal Infections Among General Hospital Inpatients in Southwestern China: A 5-Year Retrospective Study

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