First report of gastroenteritis by genotype G12 rotavirus in Dakar, Senegal

Abstract

The genotype G12 rotavirus was isolated from the stool of children 5 years old or younger with acute gastroenteritis during 1 year in three Dakar hospitals. The G12 genotype was the most common (58.25%). VP4 genotyping revealed mixed genotypes (1.94%).

Whole Genome Analysis of African G12P[6] and G12P[8] Rotaviruses Provides Evidence of Porcine-Human Reassortment at NSP2, NSP3, and NSP4

“…Interestingly, most of these early strains were associated with VP4 P[6], a traditionally animal genotype, and it was thus proposed that this might be a mechanism whereby a novel genotype might intrude into human populations to adapt for biological competitiveness (Cunliffe et al, 2009;Page et al, 2009). This was followed by reports of G12 strains circulating as prominent genotypes in multiple African countries, such as Malawi (Nakagomi et al, 2012), Cameroon (Ndze et al, 2013a), Democratic Republic of the Congo (Pukuta et al, 2014), Uganda (Odiit et al, 2014), Senegal (Dia et al, 2015), Tunisia (Moussa et al, 2017), Mozambique (Joao et al, 2018), Central African Republic (Moure et al, 2018), Nigeria (Japhet et al, 2018), and Ethiopia (Abebe et al, 2018), over recent years. Although less common, animal G12 strains have also been detected in porcine and bovine from Cameroon (Ndze et al, 2013a) and Uganda (Bwogi et al, 2017) and South Africa (unpublished data from this laboratory).…”