Emergence of G12P[6] rotavirus strains among hospitalised children with acute gastroenteritis in Belém, Northern Brazil, following introduction of a rotavirus vaccine

Guerra, Sylvia de Fátima dos Santos; Fecury, Priscylla Celeste Milhomem Silva; Bezerra, Delana Andreza Melo; Lobo, Patrícia dos Santos; Júnior, Edvaldo Tavares da Penha; Júnior, Edivaldo Costa Sousa; Mascarenhas, Joana D’Arc Pereira; Soares, Luana da Silva; Justino, Maria Cleonice Aguiar; Linhares, Alexandre da Costa

doi:10.1007/s00705-019-04295-w

Cited by 9 publications

(2 citation statements)

References 71 publications

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“…After the Rotarix TM introduction in 2006 in the National Immunization Program, an increase in G2P [4] detection rate was observed in Brazil 20 , including in the Northern region 21 . Time series analysis of RVA genotype distribution in Brazil showed a massive predominance of G2P [4] from 2006 to 2010, and a continuous decrease in the detection of this strain since 2010 4,22 , consistent with our present data.…”

Section: Discussionmentioning

confidence: 99%

Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)

Silva‐Sales

Leal

Milagres

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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Section: Discussionmentioning

confidence: 99%

Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)

Silva‐Sales

Leal

Milagres

et al. 2020

Rev. Inst. Med. trop. S. Paulo

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“…G3P[8] and G12P[8] genotypes were the most detected (data not shown), corroborating studies with samples collected during the same collection period in the northern region of Brazil [ 23 , 24 ]. Rare rotavirus genotypes have been observed relatively frequently in the northern region in Brazil [ 25 , 26 ]. Recently, G6P[8] genotypes have been emerging in the Brazilian regions of epidemiological surveillance studies covered by the Regional Rotavirus Reference Laboratory (Southern, Southeastern, and Northeastern) Ministry of Health, Brazil and PAHO (RRRL) [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

G6P[8] Rotavirus a Possessing a Wa-like VP3 Gene from a Child with Acute Gastroenteritis Living in the Northwest Amazon Region

et al. 2023

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The introduction of rotavirus A (RVA) vaccines has considerably reduced the RVA-associated mortality among children under 5 years of age worldwide. The ability of RVA to reassort gives rise to different combinations of surface proteins G (glycoprotein, VP7) and P (protease sensitive, VP4) RVA types infecting children. During the epidemiological surveillance of RVA in the Northwest Amazon region, an unusual rotavirus genotype G6P[8] was detected in feces of a 2-year-old child with acute gastroenteritis (AGE) that had been vaccinated with one dose of Rotarix® (RV1). The G6P[8] sample had a DS-1-like constellation with a Wa-like VP3 gene mono-reassortment similar to equine-like G3P[8] that has been frequently detected in Brazil previously. The results presented here reinforce the evolutionary dynamics of RVA and the importance of constant molecular surveillance.

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Reoviruses: Rotaviruses

Linhares

Justino

2022

Viral Infections of Humans

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Emergence of G12P[6] rotavirus strains among hospitalised children with acute gastroenteritis in Belém, Northern Brazil, following introduction of a rotavirus vaccine

Cited by 9 publications

References 71 publications

Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)

Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016)

G6P[8] Rotavirus a Possessing a Wa-like VP3 Gene from a Child with Acute Gastroenteritis Living in the Northwest Amazon Region

Reoviruses: Rotaviruses

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