First Report of Extended-Spectrum β-Lactamases Among Clinical Isolates of<i>Klebsiella pneumoniae</i>in Gaza Strip, Palestine

Tayh, Ghassan; SallemRym, Ben; YahiaHoussem, Ben; GharsaHaythem,; KlibiNaouel,; BoudabousAbdellatif,; Slama, Karim Ben

doi:10.1089/mdr.2016.0089

Cited by 8 publications

(4 citation statements)

References 69 publications

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“…This increase appears to be correlated with the clonal expansion of ST131 E. coli strains carrying the blaCTX-M-14 and blaCX-M-15 genes (Karfunkel et al, 2013). ESBL production by K. pneumoniae in clinical settings was reported, whereby CTX-M-15, CTX-M-14a, CTX-M-3, SHV-12, SHV-5, and SHV-33 were detected (Tayh et al, 2017). In Jordan, very few studies have addressed the prevalence of ESBL producers in clinical settings.…”

Section: Distribution Of Multi-drug Resistant Organisms In Humansmentioning

confidence: 99%

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

et al. 2019

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In the last decade, extended-spectrum cephalosporin and carbapenem resistant Gram-negative bacilli (GNB) have been extensively reported in the literature as being disseminated in humans but also in animals and the environment. These resistant organisms often cause treatment challenges due to their wide spectrum of antibiotic resistance. With the emergence of colistin resistance in animals and its subsequent detection in humans, the situation has worsened. Several studies reported the transmission of resistant organisms from animals to humans. Studies from the middle east highlight the spread of resistant organisms in hospitals and to a lesser extent in livestock and the environment. In view of the recent socio-economical conflicts that these countries are facing in addition to the constant population mobilization; we attempt in this review to highlight the gaps of the prevalence of resistance, antibiotic consumption reports, infection control measures and other risk factors contributing in particular to the spread of resistance in these countries. In hospitals, carbapenemases producers appear to be dominant. In contrast, extended spectrum beta lactamases (ESBL) and colistin resistance are becoming a serious problem in animals. This is mainly due to the continuous use of colistin in veterinary medicine even though it is now abandoned in the human sphere. In the environment, despite the small number of reports, ESBL and carbapenemases producers were both detected. This highlights the importance of the latter as a bridge between humans and animals in the transmission chain. In this review, we note that in the majority of the Middle Eastern area, little is known about the level of antibiotic consumption especially in the community and animal farms. Furthermore, some countries are currently facing issues with immigrants, poverty and poor living conditions which has been imposed by the civil war crisis. This all greatly facilitates the dissemination of resistance in all environments. In the one health concept, this work re-emphasizes the need to have global intervention measures to avoid dissemination of antibiotic resistance in humans, animals and the environment in Middle Eastern countries.

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Section: Distribution Of Multi-drug Resistant Organisms In Humansmentioning

confidence: 99%

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

et al. 2019

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“…Notably, we previously reported the pandrugresistant OXA-48-producing Proteus mirabilis and clonal spread of toxic shock syndrome toxin (TSST-1)-producing methicillin-resistant Staphylococcus aureus (MRSA) in the same area (16,17). In addition, ESBL-producing Escherichia coli and Klebsiella pneumoniae, NDM-2-producing Acinetobacter baumannii, and VIM-producing P. aeruginosa from Gaza have also been documented (18)(19)(20). Apparently, besides other challenges, Gaza is facing an antimicrobial resistance crisis as a result of the emergence of these highly multidrug-resistant organisms.…”

mentioning

confidence: 97%

Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine

Laham

Chavda

Cienfuegos-Gallet

et al. 2017

Antimicrob Agents Chemother

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Carbapenemase-producing Gram-negative bacteria (CP-GNB) have increasingly spread worldwide, and different families of carbapenemases have been identified in various bacterial species. Here, we report the identification of five VIM metallo-β-lactamase-producing isolates associated with a small outbreak in a large hospital in Gaza, Palestine. Next-generation sequencing analysis showed is harbored by a chromosomal genomic island among three strains, while is carried by a novel plasmid in two strains.

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“…We found ISEcp1 upstream of the bla CTX-M-15 gene in all strains. This insertion sequence is also able to provide promoter sequences enhancing the expression of the bla CTX-M gene (2 (30). The conjugation studies revealed the transfer of plasmids carrying bla CTX-M-15 in all isolates.…”

Section: Discussionmentioning

confidence: 97%

Strain Typing and Molecular Characterization of CTX-M-1 Group ESBL in Clinical Klebsiella pneumoniae Isolated from Children

Peerayeh

Derakhshan

Fallah

et al. 2016

Arch Pediatr Infect Dis

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First Report of Extended-Spectrum β-Lactamases Among Clinical Isolates ofKlebsiella pneumoniaein Gaza Strip, Palestine

Cited by 8 publications

References 69 publications

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

Understanding the Epidemiology of Multi-Drug Resistant Gram-Negative Bacilli in the Middle East Using a One Health Approach

Genomic Characterization of VIM Metallo-β-Lactamase-Producing Alcaligenes faecalis from Gaza, Palestine

Strain Typing and Molecular Characterization of CTX-M-1 Group ESBL in Clinical Klebsiella pneumoniae Isolated from Children

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