First Report of Chronic Pulmonary Infection by KPC-3-Producing and Colistin-Resistant Klebsiella pneumoniae Sequence Type 258 (ST258) in an Adult Patient with Cystic Fibrosis

Delfino, Emanuele; Giacobbe, Daniele Roberto; Bono, Valerio Del; Coppo, Erika; Marchese, Anna; Manno, G.; Morelli, Patrizia; Minicucci, L.; Viscoli, Claudio

doi:10.1128/jcm.03199-14

Cited by 11 publications

(10 citation statements)

References 19 publications

(19 reference statements)

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“…for longer than 6 months) among German CF patients [2] . Besides that, reports of KPC-producing K. pneumoniae in individuals with CF supports a role for members of the Enterobacteriaceae as possible CF pathogens [1] , [2] . Our group reported the first isolation of KPC-2-producing K. pneumoniae from two Brazilian patients with CF patients pulmonary exacerbations.…”

Section: Discussionmentioning

confidence: 82%

“…However, no KPC-producing strains grew from subsequent sputum cultures [2] . More recently, the establishment of a chronic lung infection in a patient with CF with a colistin-resistant KPC-3-producing K. pneumoniae was reported [1] . The isolates were persistently isolated from sputum cultures collected from the patient for at least 6 consecutive months.…”

Section: Discussionmentioning

confidence: 99%

“…Enterobacteriaceae are uncommonly isolated from respiratory specimens and appear to play a minor role in lung infection in individuals with cystic fibrosis (CF). However, increasing reports of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae in individuals with CF is a matter of concern [1] , [2] . This study describes the first report of a KPC-2 and QnrB-1-producing Enterobacter cloacae from an individual with CF.…”

Section: Introductionmentioning

confidence: 99%

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Enterobacter cloacae harbouring blaKPC-2 and qnrB-1 isolated from a cystic fibrosis patient: a case report

Alves

Carvalho-Assef

Neto

et al. 2018

New Microbes and New Infections

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enterobacter cloacae harbouring blaKPC-2 and qnrB-1 isolated from a cystic fibrosis patient: a case report

Alves

Carvalho-Assef

Neto

et al. 2018

New Microbes and New Infections

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“…The MLST International clone ST-258 has been recognized as the prevalent ST of carbapenem-resistant K. pneumoniae isolates worldwide [45,46,47,48]. Herein, we described an isolate that belongs to sequence type ST-14 which has been associated with pan resistant isolates and the production of OXA-48 and NDM carbapenemases with a higher colistin rate of resistance when compared with isolates outside the cluster (37.1% vs. 27.1%) [49].…”

Section: Discussionmentioning

confidence: 99%

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

et al. 2018

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Herein, we describe a case report of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae isolates that were identified from the same patient at a Tertiary University Hospital Centre in Portugal. Antimicrobial susceptibility and the molecular characterization of resistance and virulence determinants were performed. PCR screening identified the presence of the resistance genes blaKPC-3, blaTEM-1 and blaSHV-1 in both isolates. The KPC-3 K. pneumoniae isolate belonged to the ST-14 high risk clone and accumulated an uncommon resistance and virulence profile additional to a horizontal dissemination capacity. In conclusion, the molecular screening led to the first identification of the A. baumannii KPC-3 producer in Portugal with a full antimicrobial resistance profile including tigecycline and colistin.

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“…5 Several cases of multidrug-resistant Enterobacteriaceae chronic infections have recently been reported. [6][7][8] The purpose of this study was to characterize antimicrobial susceptibility trends among organisms isolated from the respiratory tract of CF patients.…”

mentioning

confidence: 99%

Increasing Incidence of Multidrug Resistance Among Cystic Fibrosis Respiratory Bacterial Isolates

Rutter

Burgess

2017

Microbial Drug Resistance

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Pseudomonas aeruginosa and Staphylococcus aureus are common pathogens in cystic fibrosis (CF) patients with increasing multidrug resistance (MDR). This study characterized antimicrobial susceptibility trends among organisms isolated from the respiratory tract of CF patients. Microbiological culture and sensitivity results for all CF patients were collected from January 2010 through December 2014. Minimum inhibitory concentrations were obtained using Phoenix and Etest methods. Clinical and Laboratory Standards Institute guidelines were used to remove duplicate isolates and develop antimicrobial susceptibility reports. MDR was defined as resistance to one agent in three or more antibiotic classes or oxacillin resistance in S. aureus. Overall, 542 bacterial isolates from 376 cultures were analyzed for trends. P. aeruginosa (41%), S. aureus (40%), and Stenotrophomonas maltophilia (8%) were the most commonly isolated organisms. Multidrug-resistant organism isolation increased from 39% to 49% (r = 0.76, p = 0.13), while representing 47.6% of all isolates. Multidrug-resistant P. aeruginosa incidence increased each year from 26% to 43% (r = 0.89, p = 0.046), while P. aeruginosa isolation decreased from 47% to 38% over the study period (r = -0.93, p = 0.02). MRSA accounted for 62.6% of all S. aureus isolated, while overall multidrug-resistant S. aureus incidence was 73.1% in all cultures. MDR among common pathogens in CF continues to increase. Empiric therapy for CF exacerbations should be targeted to previous antimicrobial susceptibility, and P. aeruginosa and S. aureus should be empirically covered.

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First Report of Chronic Pulmonary Infection by KPC-3-Producing and Colistin-Resistant Klebsiella pneumoniae Sequence Type 258 (ST258) in an Adult Patient with Cystic Fibrosis

Cited by 11 publications

References 19 publications

Enterobacter cloacae harbouring blaKPC-2 and qnrB-1 isolated from a cystic fibrosis patient: a case report

Enterobacter cloacae harbouring blaKPC-2 and qnrB-1 isolated from a cystic fibrosis patient: a case report

First Description of Colistin and Tigecycline-Resistant Acinetobacter baumannii Producing KPC-3 Carbapenemase in Portugal

Increasing Incidence of Multidrug Resistance Among Cystic Fibrosis Respiratory Bacterial Isolates

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