First Report for Levodopa Electrocatalytic Oxidation Based on Copper Metal‐Organic Framework (MOF): Application in a Voltammetric Sensor Development for Levodopa in Real Samples

Abstract

Levodopa (LD) determination was achieved for the first time by a cooper metal‐organic framework (MOF) based nanocomposite modified electrode. This research describes a simple, sensitive and cost‐effective electrochemical method for the detection of LD in real samples and the laboratory samples. This method is based on LD oxidation on glassy carbon electrode (GCE) surface modified with multi‐walled carbon nanotubes and copper terephthalic acid MOF (MWCNTs/Cu (TPA) MOF) nanocomposite. MOF was synthesized by the hydrothermal method. The synthesized MOF was characterized by Fourier‐transform infrared spectrophotometry (FT‐IR), energy‐dispersive X‐ray spectroscopy (EDX), field emission scanning electron microscopy (FESEM) and X‐ray diffraction (XRD). Electrochemical studies were accomplished by square wave voltammetry (SWV) and cyclic voltammetry (CV). The applied MOF, as a Cu‐containing synthetic peroxidase enzyme, can electrocatalyze oxidation of LD on the electrode surface and in incorporation with MWCNTs illustrated satisfactory synergic electrocatalytical properties which leads to sensitive detection of LD in the human serum sample. Limit of detection (LOD), sensitivity and linear range were 2 nmol L–1, 2.26 μA/μmol L–1 and 0.9‐35 μmol L–1 respectively, which in compared to other enzymatic or non‐enzymatic sensors were completely satisfying. Ultimately, stability, repeatability and reproducibility of as‐prepared sensor were investigated and the results were acceptable.

A Series of Cobalt-Based Coordination Polymer Crystalline Materials as Highly Sensitive Electrochemical Sensors for Detecting Trace Cr(VI), Fe(III) Ions, and Ascorbic Acid

“…The peaks located at 1020–1050 and 1620–1670 cm –1 correspond to the ν­(C–C) and ν­(C–N) in the pyridine ring of the 4-dptb ligand, respectively. The peak positions at approximately 1390–1420 cm –1 for 1 – 5 are attributed to the stretching vibration of carboxylic groups, and peaks at 1392–1583 cm –1 are attributed to the phenyl ring stretching vibration . Especially, for compounds 1 and 2 , there are lattice water molecules and −OH in the frameworks; thus, the peaks of −OH groups are observed at about 3300 cm –1 . , Also, the characteristic peak at 3416 cm –1 for 3 can be assigned to the ν­(−NH−) stretching vibrations.…”

A sensitive electrochemical DNA biosensor for determination of Capecitabine anticancer drug based on ss-DNA/RGO/MoS2/CPE electrode

“…Among the electrochemical methods, electrochemical sensor and biosensors possess several advantages including high sensitivity and selectivity, rapid response time, miniaturization and portability, low cost and simple instrumentation, operational versatility, real-time monitoring and continuous measurement, wide range of applicability, ease of functionalization [14][15][16][17][18][19][20][21][22][23]. These advantages collectively make electrochemical sensors powerful tools for monitoring and quantifying various analytes in a wide range of elds, contributing to their widespread use and ongoing research and development In recent years, electrochemical DNA biosensors have gained prominence in recent years due to their high sensitivity, rapid response, and speci city in detecting target molecules [24][25][26][27][28].…”

A simple and low-cost electrochemical sensor based on a graphite sheet electrode modified by carboxylated multiwalled carbon nanotubes and gold nanoparticles for detection of acyclovir

“…In electrochemical research, efficient modifiers including different metal and metal oxide nanoparticles, 36,37 carbon nanomaterials, 38 conducting polymers 39,40 and metal organic frameworks 41,42 have been developed for the modification of electrodes in order to improve the LOD, LDR and their selectivity in determining drug molecules. On the other hand, the most common modified electrodes are those carbon-based electrodes such as the glassy carbon electrode (GCE), 43 carbon paste electrode (CPE), 44 pencil graphite electrode (PGE) 45 and graphite sheet electrode (GSE).…”