First insights into human acetabular labrum cell metabolism

Abstract

The findings in this study demonstrated that the acetabular labrum is populated with unique highly active fibrochondrocyte-like cells. These cells are capable of expressing and releasing pro-inflammatory enzymes and cytokines and react to a pro-inflammatory stimulus. In this way, they contribute obviously to disturbed tissue function in hip labrum pathology.

Hip chondropathy at arthroscopy: prevalence and relationship to labral pathology, femoroacetabular impingement and patient-reported outcomes

“…Since hip chondropathy at arthroscopy represents early-onset hip OA, it appears that those with more advanced chondropathy have progressed further along the disease continuum of hip OA. As severity of chondropathy increases, involvement in structures capable of generating nociception, such as the subchondral bone41 and the acetabular labrum,42 may also increase, creating a perception of greater pain and worse symptoms or function in these patients. The collection of PRO data by an independent researcher in a physiotherapy clinic, rather than a surgeon's rooms, may also explain the lower scores, as patients may be more likely to report higher scores when the data are collected by the treating surgeon.…”

Acetabular Labral Reconstruction With Autologous Tendon Tissue in a Porcine Model

“…19 Hence, these cells may convert to fibrocartilaginous cells within the labral defect, which changes the collagen gene profile of the tendon by secreting collagen types 1, 2, and 3. One study demonstrated that highly active fibrochondrocytes exist within the acetabular labrum of humans, 3 which may contribute to the healing process of labral defects in humans.…”

“…A previous study in vitro characterized the ECM genes (COL1A1, COL2A1, aggrecan, and SOX-9) and proinflammatory mediators (MMP-1, -2, -3, -9, -13; IL-6, ADAMTS-4, ADAMTS-5, and TIMP-1) expressed by human acetabular labrum cells compared with articular chondrocytes and meniscus cells. 3 Our study aimed to clarify the content of ECM components of implants in acetabular labral reconstruction. Therefore, we chose the COL family of genes for analysis.…”

Inflammation in joint injury and post-traumatic osteoarthritis

“…Infrapatellar fat pads from patients with knee OA have increased numbers of macrophages, granulocytes and lymphocytes [40], and this tissue can contribute to production of inflammatory cytokines in knee OA patients [41, 42]. Fibrocartilaginous structures such as the meniscus in the knee [43] and the labrum in the hip [44] respond to and produce inflammatory mediators. Understanding which tissues and cell types contribute to inflammation has important implications for therapeutic targeting.…”