First-in-Class Combination Therapy of a Copper(II) Metallo-Phosphorus Dendrimer with Cytotoxic Agents

Mignani, Serge; Brahmi, Nabil El; Cresteil, Thierry; Majoral, Jean‐Pierre

doi:10.1159/000486680

Cited by 12 publications

(12 citation statements)

References 20 publications

(28 reference statements)

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“…Because of many interesting properties, phosphorus dendrimers are of great interest for drug delivery applications, anti-prion, imaging [27], anti-cancer [28,29,30], and anti-inflammatory agents [31,32,33]. Moreover, polyanionic and polycationic phosphorus dendrimers have been proposed as carriers for photosensitizers in photodynamic therapy [34].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

et al. 2019

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Despite the numerous studies on dendrimers for biomedical applications, the antibacterial activity of anionic phosphorus dendrimers has not been explored. In our research, we evaluated the antibacterial activity of modified polycationic and polyanionic dendrimers in combination with levofloxacin (LVFX) against Gram-negative (Escherichia coli ATCC 25922, Proteus hauseri ATCC 15442) and Gram-positive (Staphylococcus aureus ATCC 6538) bacteria. In the case of Gram-negative bacteria, we concluded that a combination of dendrimers and antibiotic gave satisfactory results due to a synergistic effect. The use of fluoroquinolone antibiotics, such as LVFX, not only caused resistance in disease-causing microorganisms but also increased environmental pollution. Therefore, reduction of drug dosage is of general interest.

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Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

et al. 2019

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“…The anti-proliferative activity of To overcome cross-therapy drug resistance in cancers, the strategy of a combination of drugs using different modes of action was used [40]. The anti-proliferative activity of 1G3-Cu in a cocktail of several canonical cytotoxic drugs used in chemotherapy, such as camptothecin (topoisomerase I inhibitor), cisplatin (DNA cross-linker/intercalator), taxol (microtubule stabilizer), MG-132 (proteasome inhibitor) and doxorubicin (DNA intercalator/topoisomerase II inhibitor), is an example: no additive outcome with camptothecin and cisplatin was observed, but there was an additive response with paclitaxel and MG-132 and also a very interesting synergy with doxorubicin [32].…”

Section: Neutral Phosphorus Dendrimers As Anti-cancer Agentsmentioning

confidence: 99%

“…The main therapeutic domains developed by J.-P. Majoral and A.-M. Caminade are as follows: anti-inflammatory [ 27 , 28 ], anti-tuberculosis [ 29 ], against Alzheimer’s disease [ 30 ], antiprion [ 31 ] and anti-cancer [ 32 , 33 , 34 , 35 ]. The theragnostic realm in oncology [ 36 ] has also been developed using phosphorus dendrimers and dendrons [ 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

et al. 2021

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Based on phenotypic screening, the major advantages of phosphorus dendrimers and dendrons as drugs allowed the discovery of new therapeutic applications, for instance, as anti-cancer and anti-tuberculosis agents. These biological activities depend on the nature of the chemical groups (neutral or cationic) on their surface as well as their generation. As lessons to learn, in the oncology domain, the increase in the generation of metallo-dendrimers is in the same direction as the anti-proliferative activities, in contrast to the development of polycationic dendrimers, where the most potent anti-tuberculosis phosphorus dendrimer was observed to have the lowest generation (G0). The examples presented in this original analysis of phosphorus dendrimers and dendrons provide support for the lessons learned and for the development of new nanoparticles in nanomedicine.

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“…No additive effect was observed with camptothecin and cisplatin, but it was observed with paclitaxel and MG132. More interestingly, synergy was observed with doxorubicin [ 95 ].…”

Section: Phosphorus Dendrimers As Carriers Of Anticancer “Drugs”mentioning

confidence: 99%

Phosphorus Dendrimers as Nanotools against Cancers

Caminade

2020

Molecules

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This review concerns the use of dendrimers, especially of phosphorhydrazone dendrimers, against cancers. After the introduction, the review is organized in three main topics, depending on the role played by the phosphorus dendrimers against cancers: (i) as drugs by themselves; (ii) as carriers of drugs; and (iii) as indirect inducer of cancerous cell death. In the first part, two main types of phosphorus dendrimers are considered: those functionalized on the surface by diverse organic derivatives, including known drugs, and those functionalized by diverse metal complexes. The second part will display the role of dendrimers as carriers of anticancer “drugs”, which can be either small molecules or anticancer siRNAs, or the combination of both. In the third part are gathered a few examples of phosphorhydrazone dendrimers that are not cytotoxic by themselves, but which under certain circumstances induce a cytotoxic effect on cancerous cells. These examples include a positive influence on the human immune system and the combination of bioimaging with photodynamic therapy properties.

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First-in-Class Combination Therapy of a Copper(II) Metallo-Phosphorus Dendrimer with Cytotoxic Agents

Cited by 12 publications

References 20 publications

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

Synergistic Effects of Anionic/Cationic Dendrimers and Levofloxacin on Antibacterial Activities

First-in-Class Phosphorus Dendritic Framework, a Wide Surface Functional Group Palette Bringing Noteworthy Anti-Cancer and Anti-Tuberculosis Activities: What Lessons to Learn?

Phosphorus Dendrimers as Nanotools against Cancers

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