2020
DOI: 10.1186/s12879-020-05522-5
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First identification of Anaplasma phagocytophilum in both a biting tick Ixodes nipponensis and a patient in Korea: a case report

Abstract: Background Human granulocytic anaplasmosis (HGA) is a tick-borne infectious disease caused by Anaplasma phagocytophilum. To date, there have been no reported cases of A. phagocytophilum infection found in both the biting tick and the patient following a tick bite. Case presentation An 81-year-old woman presented with fever following a tick bite, with the tick still intact on her body. The patient was diagnosed with HGA. The tick was identified as Ixodes nipponensis by morphological and molecular biological d… Show more

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Cited by 13 publications
(9 citation statements)
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“…Moreover, Xu et al [39] investigated the infection prevalence of B. burgdorferi sensu lato, B. miyamotoi, and A. phagocytophilum in human-biting ticks collected over a 10-year period in three western states of the US [39]. However, studies on TBPs in the ROK have primarily been conducted on wild or domesticated animals, such as goats [23], deer [24], and cattle [25], and several sporadic cases have been reported in patients with tick bites or in individuals visiting local hospitals [26,27]. To the best of our knowledge, this is the first report of a nationwide survey to test ticks removed from humans in the ROK.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Moreover, Xu et al [39] investigated the infection prevalence of B. burgdorferi sensu lato, B. miyamotoi, and A. phagocytophilum in human-biting ticks collected over a 10-year period in three western states of the US [39]. However, studies on TBPs in the ROK have primarily been conducted on wild or domesticated animals, such as goats [23], deer [24], and cattle [25], and several sporadic cases have been reported in patients with tick bites or in individuals visiting local hospitals [26,27]. To the best of our knowledge, this is the first report of a nationwide survey to test ticks removed from humans in the ROK.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, 16 ticks collected between 2014 and 2017 from residents of the southwestern region of the ROK tested positive for A. phagocytophilum (three ticks), Babesia gibsoni (one tick), B. microti (two ticks), and Rickettsia spp. (12 ticks) [26], with A. phagocytophilum infection detected in both ticks and patients [27]. However, no research has been conducted based on nationwide surveys.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, we detected the same pathogen with A. phagocytophilum in Tick30 and the blood of these tick-bitten patients. It has been identified via PCR and increased antibody levels (IgG/IgM) using an indirect immunofluorescence assay according to the sample collection date of these patients [22]. Further study will need to be conducted to analyze patient characteristics from clinical data of more ticks and these tick-bitten patients.…”
Section: Discussionmentioning
confidence: 99%
“…The pathogenic mechanism of human granulocytic anaplasmosis (HGA) is mainly that the function of neutrophils is damaged following infection by pathogens, resulting in abnormal adhesion, migration, neutrophil degranulation, and phagocytosis, which in turn cause a series of immunopathological changes. 9 In this case, the patient had fever and thrombocytopenia, and the possibility of Anaplasma phagocytophilum infection existed. However, considering that the cause of the disease was clear in this case, HGA could be excluded.…”
Section: Discussionmentioning
confidence: 82%