First experience with a new form of orthotopic ileal neobladder (Leuven N-Pouch) following radical cystectomy

Akand, Murat; Kılıç, Özcan; Bocu, Kadir; Harmankaya, Ísmail; Aydoğan, Muhammed Furkan Furkan

doi:10.5152/tud.2019.68704

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…All IC patients received a Bricker anastomosis, and Leuven N-pouch was performed for the patients who had a NB. The technique for each UD was described previously (10)(11)(12). Briefly, Leuven N-pouch was created with a 50-cm segment of preterminal ileum that was folded into four equally long parts.…”

Section: Methodsmentioning

confidence: 99%

Comparison of postoperative complications of ileal conduits versus orthotopic neobladders

Demaegd¹,

Albersen²,

Muilwijk³

et al. 2020

Transl Androl Urol

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Background: Radical cystectomy (RC) and urinary diversion (UD), with either an ileal conduit (IC) or an orthotopic neobladder (NB), is a complex surgery, in which various complications can occur. In this study, we compared postoperative complication rates after a RC and UD performed for the treatment of muscleinvasive bladder cancer or recurring high-risk non-muscle-invasive bladder cancer in our center. Methods: We retrospectively included 604 patients that underwent UDs from December 1996 to August 2015. Complications were classified by type and severity according to the Clavien-Dindo classification (CDC). Univariate and multivariate analyses were performed to identify predictive factors of short-term (≤30 d), intermediate-term (31-90 d), and long-term (>90 d) complications.Results: Four hundred and forty-five (74%) and 159 (26%) patients received ICs and NBs, respectively. These groups had significantly different long-term complication rates (IC: 39.7% vs. NB: 49%, P=0.046), but similar short-term (P=0.319) and intermediate-term complication rates (P=0.397). Short-term complications (CDC I-V) were predicted by male gender, age-adjusted Charlson comorbidity index (aCCI) ≥3, and American Society of Anesthesiologists (ASA) score ≥3. Compared to minor short-term complications (CDC I-II), major short-term complications (CDC III-V) were predicted by male gender and a previous abdominal/pelvic surgery, and long-term major complications were predicted by the type of UD (NB). Conclusions:The increasing risk of short-term complications with increasing aCCI and ASA score can be used when counseling the patients who are planned to undergo a RC with UD. Patients that receive NBs should be informed of the increased risk of reoperations compared to an IC.

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Section: Methodsmentioning

confidence: 99%

Comparison of postoperative complications of ileal conduits versus orthotopic neobladders

Demaegd¹,

Albersen²,

Muilwijk³

et al. 2020

Transl Androl Urol

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Study of the constrictor properties of the neobladder under the influence of new chemical compounds in vivo experiment

Савчук

Kostyev

Shmatkova

2021

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The orthotopic ileocystoplasty is the most preferred urine derivation method for patients after removal of the bladder. The best quality of life, self-esteem, cosmetic appearance of one’s own body, and the possibility of physiological urination characterize the artificial bladder as the “gold standard” of urine derivation. There are a greater number of postoperative complications associated with the functionality of the neobladder, considering the complexity of orthotopic derivation of urine. The autocaturation is required in some patients day or night urinary incontinence, and in the other group, periodic urinary retention. Urinary retention is more common in women up to 43 % compared with 20 % in men, who need intermittent catheterization. The aim of investigation was to evaluate the possibility of pharmacological correction of contractile activity of mini-pigs neobladder in vivo, under the influence of new chemical compounds and the anticholinesterase drug nivalin. Materials and methods Experimental studies were performed on 21 female mini-pigs, with an average age of 6 to 14 months. The duration of the experiment was 12 months. Performing of enterocystometry in experimental animals is possible only under anesthesia and, accordingly, only part of the urodynamic parameters can be obtained. Results. The obtained results of in vivo experimental studies demonstrated the constrictor activity of the studied new chemical compounds. Compound I in comparison with the control group statistically significantly increased basal tone by 62.09 %, the amplitude of contractions by 37.34 %, and the duration of contractions by 35.71 %. The new chemical compound II, in comparison with the control group, showed less pronounced results of constrictor activity, so the basal tone statistically significantly increased by 38.86 %, and the amplitude of contractions by 15.0 %. Conclusion. Thus, under the influence of new chemical compounds in the conditions of an experimental artificial bladder, constrictor properties are proved, which require further research and study. In turn, cholinomimetic nivalin has prospects for use in urology, in particular in patients with hypoactive forms of artificial and neurogenic bladder.

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First experience with a new form of orthotopic ileal neobladder (Leuven N-Pouch) following radical cystectomy

Cited by 2 publications

References 15 publications

Comparison of postoperative complications of ileal conduits versus orthotopic neobladders

Comparison of postoperative complications of ileal conduits versus orthotopic neobladders

Study of the constrictor properties of the neobladder under the influence of new chemical compounds in vivo experiment

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