First Divergent Strategy Using Two AB<sub>2</sub> Unprotected Monomers for the Rapid Synthesis of Dendrimers

Brauge, Laurent; Magro, Germinal; Caminade, Anne‐Marie; Majoral, Jean‐Pierre

doi:10.1021/ja0029228

Cited by 94 publications

(49 citation statements)

References 39 publications

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“…In Figure 15a, the divergent growth method is initiated from the active sites of core part [77], which is synthesized step-by-step and can obtain the unique molecular weight, such as the highest reported generations (G10) of PAMAM [78]. Another approach is the convergent assembly of welldefined branches to the core [79].…”

Section: Structural Features Of Dendrimers and Dendrimer Monolayersmentioning

confidence: 99%

Dendrimers as Dopant Atom Carriers

Wu¹,

Dan²

2018

Dendrimers - Fundamentals and Applications

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Properties of modern semiconducting transistors and future electron or quantum devices are essentially determined by single dopant atoms. How to precisely control the individual dopant position is one of the key factors to advance these technologies. In this chapter, we first briefly introduce the research progress in single dopant devices. To fabricate single dopant devices at large scale, we then overview our previous propose to control the locations of single dopants by self-assembly of large molecules (polyglycerols) with each carrying one dopant atom. The synthesis process, doping properties, and challenges of the molecular doping technique will be thoroughly elaborated before we conclude this chapter.

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Section: Structural Features Of Dendrimers and Dendrimer Monolayersmentioning

confidence: 99%

Dendrimers as Dopant Atom Carriers

Wu¹,

Dan²

2018

Dendrimers - Fundamentals and Applications

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“…The step-by-step use of these branched monomers in alternation starting from (S)P(OC 6 H 4 CHO) 3 as core has been carried out up to the fourth generation dendrimer shown in Figure 13. All reactions were quantitative, with only water and nitrogen as by-products [94]. Such synthetic process has been applied to other AB 2 monomers, having an azide and two hydrazines for one of them, an aldehyde and two phosphines for the other one, and using a triphosphine as core.…”

Section: Functions As Intrinsic Constituents Of the Branches Of Layermentioning

confidence: 99%

“…Comparison of the properties of the dendrimers and of the hyperbranched polymers displayed large differences in the polydispersity index as expected (PDI between 1.16 and 8.1, with Mw ranging from 3600 to 36,700 for the hyperbranched polymer; PDI 1.029 for the fifth generation dendrimer with Mw = 60,200). Furthermore, the variation of the intrinsic viscosity with Mw is very different: a bell-shaped curve for the dendrimers, with a maximum for the third generation, contrarily to an almost constant value for the hyperbranched polymers [94]. Another type of diphosphine has been used also for the synthesis of dendrimers including P=N-P=S linkages at all layers [99].…”

Section: Functions As Intrinsic Constituents Of the Branches Of Layermentioning

confidence: 99%

Bifunctional Phosphorus Dendrimers and Their Properties

Caminade

Majoral

2016

Molecules

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Dendrimers are hyperbranched and monodisperse macromolecules, generally considered as a special class of polymers, but synthesized step-by-step. Most dendrimers have a uniform structure, with a single type of terminal function. However, it is often desirable to have at least two different functional groups. This review will discuss the case of bifunctional phosphorus-containing dendrimers, and the consequences for their properties. Besides the terminal functions, dendritic structures may have also a function at the core, or linked off-center to the core, or at the core of dendrons (dendritic wedges). Association of two dendrons having different terminal functions leads to Janus dendrimers (two faces). The internal structure can also possess functional groups on one layer, or linked to one layer, or on several layers. Finally, there are several ways to have two types of terminal functions, besides the case of Janus dendrimers: either each terminal function bears two functions sequentially, or two different functions are linked to each terminal branching point. Examples of each type of structure will be given in this review, as well as practical uses of such sophisticated structures in the fields of fluorescence, catalysis, nanomaterials and biology.

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“…The dendron is produced by a reiterative coupling of branch units, and the process is followed by a core anchoring step, enabling the formation of dendrimers of various generations. Though both synthesis approaches pose some challenges towards large-scale production of dendrimers [143], alternative methods have been proposed [144–147]. The choice of the initiator core, the branching cells and the external surface functional groups can bring about unlimited types of dendrimers.…”

Section: Poly(amidoamine) Dendrimersmentioning

confidence: 99%

Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers

Xu¹,

Wang²,

Pack³

2010

CPD

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Gene therapy is a potential medical solution that promises new treatments and may hold the cure for many different types of diseases and disorders of the human race. However, gene therapy is still a growing medical field and the technology is still in its infancy. The main challenge for gene therapy is to find safe and effective vectors that are able to deliver genes to the specific cells and get them to express inside the cells. Due to safety concerns, synthetic delivery systems, rather than viral vectors, are preferred for gene delivery and significant efforts have been focused on the development of this field. However, we are faced with problems like low gene transfer efficiency, cytotoxicity and lack of cell-targeting capability for these synthetic delivery systems. Over the years, we have seen a variety of new and effective polymers which have been designed and synthesized specifically for gene delivery. Moreover, various strategies that aimed at enhancing their physicochemical properties, improving transfection efficiency, reducing cytotoxicity as well as incorporating functional groups that offer better targetability and higher cellular uptake are established. Here, we look at two potential polymeric carriers, chitosan and poly(amidoamine) dendrimers, which have been widely reported for gene delivery. For chitosan, the interest arises from their availability, excellent non-cytotoxicity profile, biodegradability and ease of modification. For poly(amidoamine) dendrimers, the interest arises from their ease of synthesis with controlled structure and size, minimal cytotoxicity, biodegradability and high transfection efficiencies. The latest developments on these polymers for gene delivery will be the main focus of this article.

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First Divergent Strategy Using Two AB₂ Unprotected Monomers for the Rapid Synthesis of Dendrimers

Cited by 94 publications

References 39 publications

Dendrimers as Dopant Atom Carriers

Dendrimers as Dopant Atom Carriers

Bifunctional Phosphorus Dendrimers and Their Properties

Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers

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First Divergent Strategy Using Two AB2 Unprotected Monomers for the Rapid Synthesis of Dendrimers

Cited by 94 publications

References 39 publications

Dendrimers as Dopant Atom Carriers

Dendrimers as Dopant Atom Carriers

Bifunctional Phosphorus Dendrimers and Their Properties

Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers

Contact Info

Product

Resources

About

First Divergent Strategy Using Two AB₂ Unprotected Monomers for the Rapid Synthesis of Dendrimers