First detection of bovine papillomavirus type 2 in cutaneous wart lesions from ovines

Mazzuchelli-de-Souza, J.; Carvalho, Rogério Falleiros; Módolo, Diego Grando; Thompson, Cameron; Araldi, Rodrigo Pinheiro; Stocco, Rita de Cássia

doi:10.1111/tbed.12892

Cited by 13 publications

(20 citation statements)

References 31 publications

(29 reference statements)

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“…Herein, we report evidence that BPV-1 is not only capable of infecting sheep, but is also able to cause papillomas and cutaneous lesions without fibroblastic involvement. Similar behavior has been previously described for BPV-2 in infected sheep in Brazil [ 13 ], where lesions identified as papillomas by histopathological analysis were localized on the hind feet.…”

Section: Discussionsupporting

confidence: 83%

“…Recent findings have demonstrated that sheep are also permissive hosts for BPVs. Among deltapapillomaviruses, BPV-2 has been detected in sheep warts from Brazil [ 13 ]; BPV-1, -2 and -13 have been detected in the blood of healthy sheep from Sardinia and Campania [ 14 , 15 ]; while BPV-2 and BPV-13 DNA and E5 oncoprotein have been documented to be expressed in congenital lesions on lambs in a flock in Sardinia, in the form of proliferative tissues in the gingiva and oral mucosa [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily

et al. 2020

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A proliferative cauliflower lesion was excised from the udder of a sheep. Histological investigation confirmed the macroscopic classification of the lesion as a papilloma, without any fibroblastic proliferation. PCR revealed the presence of bovine papillomavirus (BPV), which was further confirmed by the identification of a Deltapapillomavirus 4 by Next Generation Sequencing analysis. This was subsequently classified as bovine papillomavirus type 1. Negative staining electron microscopy (EM) analyses produced negative test results for papillomavirus particles. RNA in situ hybridization (ISH) confirmed the presence of BPV-1. The results further confirm the ability of BPVs belonging to the Deltapapillomavirus genus to infect distantly related species and to cause lesions that are different from sarcoids.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily

et al. 2020

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“…E2 sequence shared most identity with the reference sequence (99.3%–100%), suggesting that BPV‐1 exhibits low genetic diversity within the E2 region, as has been reported for E2 of HPV‐16 known as high‐risk types and has most extensively been studied (Veress, Szarka, Dong, Gergely, & Pfister, ). This result also in accordance with that the proteins essential to the viral cycle (L1, L2, E1, and E2) do not accept high mutations (Mazzuchelli‐de‐Souza et al, ).…”

Section: Discussionsupporting

confidence: 87%

“…Another reason for BPV attracts most of the attention in the field was because of its cross‐infection between different species and been reported to associated with carcinoma genesis in equids (Chambers et al, ), ovines (Mazzuchelli‐de‐Souza et al, ), buffalo (Silvestre et al, ), zebras (Silvestre et al, ), yaks (Chambers et al, ) and other kinds of ruminates (da Silva et al, ).…”

Section: Introductionmentioning

confidence: 99%

Detection and genomic characterization of Bovine papillomavirus isolated from Chinese native cattle

Peng

et al. 2019

Transbound Emerg Dis

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Bovine papillomaviruses (BPV) are small circular DNA viruses which can be widely spread in herd, inducing cattle tumours, therefore, leading economic losses in dairy and beef production industries. BPV‐leads symptoms include cutaneous papillomas, fibropapillomas, urinary bladder and oesophageal carcinoma. As one of the most important producers of beef in the world, China has not provided systematic research to prevent the harm of BPV, particularly in papillomavirus molecular characterization which presents among Chinese native cattle which was known to have higher disease resistance. In this study, skin papilloma was observed and samples were collected following by histopathological analysis. We analysed all neoplasms samples and reviewed their degrees in acanthosis and/or hyperkeratosis. Full‐length genomic sequencing was applied for all four isolated strains (JX180408, LA150909, HX160815, and BS160810) to exploring the molecular reason why BPV currently prevalent in Chinese native cattle. As a result, we identified that these four isolates were classified as BPV‐1 and clustered into the Deltapapillomavirus genera. Our study also identified that BPV 1 isolates from Chinese indigenous cattle breeds belong to subtypes A which has a closer genetic background compare with their common ancestor and suggest it can be a more ancestral species. European isolates more recently diverged group (group B) contained almost exclusively European samples. In this study, we analysed the similarity of ORF between Chinese isolated BPV 1 and BPV 1 reference strains and listed results. This study provides the complete genomic characterization of BPVs circulating in Chinese native cattle breeds for the first time, which provide a detailed description of how diverse strains may cause skin tumour among Chinese local breed cattle therefore critical for further epidemiological study of relevant diseases.

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“…Bovine papillomavirus (BPV) is an oncogenic virus belonging to the Papillomaviridae family, which infects the epithelium and mucosa of many animals including cattle. Although papillomaviruses are usually species-specific, BPV has been observed in other animals such as giraffes, buffalo, sheep and horses [1][2][3][4][5][6][7]. BPVs are classified into five genera and 28 types have been identified so far.…”

Section: Introductionmentioning

confidence: 99%

High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

et al. 2020

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Bovine papillomavirus (BPV) can cause damage to the epithelial and mucosal tissue and currently presents 28 known types. Not all BPV types are associated with the development of cancer in cattle. Studies have shown that variants of human papillomavirus types can present different pathogenic profiles. However, despite the similarity, it is not yet known whether variants of BPV types can also present varying degrees of pathogenicity. Thus, the aim of this study was to evaluate the genetic variability of BPV types and variants isolated in Northeastern Brazil. Samples were obtained from animals with papillomatous lesions. BPV DNA was detected by the amplification of the L1 gene and genotyping was performed by sequencing. Mutations were analyzed in a phylogenetic, structural and functional context. In total, 52 positive samples were obtained and 11 different BPV types were identified in the samples. Ten putative new BPV types were also identified. In addition, several non-synonymous mutations were identified and predicted to alter protein stability, having an impact on immune evasion. The study demonstrated a high genetic diversity of BPV in the region with a large number of mutations identified, serving as a basis for more efficient control measures to be adopted for bovine papillomatosis.

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First detection of bovine papillomavirus type 2 in cutaneous wart lesions from ovines

Cited by 13 publications

References 31 publications

Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily

Bovine Papillomavirus 1 Gets Out of the Flock: Detection in an Ovine Wart in Sicily

Detection and genomic characterization of Bovine papillomavirus isolated from Chinese native cattle

High Genotypic Diversity, Putative New Types and Intra-Genotype Variants of Bovine Papillomavirus in Northeast Brazil

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