First Detection and Genome Sequencing of SARS-CoV-2 Lambda (C.37) Variant in Symptomatic Domestic Cats in Lima, Peru

Schiaffino, Francesca; Ferradas, Cusi; Jara, Luis M.; Salvatierra, Guillermo; Dávila-Barclay, Alejandra; Sánchez-Carrión, Camila; Ulloa, Alexandra; Mascaro, Lucero; Pajuelo, Mónica; Sarmiento, Luis Guevara; Fernández, Manolo; Zimic, Mirko

doi:10.3389/fvets.2021.737350

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Whole‐genome sequencing of paired virus samples collected from animals and owners found that they were all the same B.1.575 variant strain 54 . In addition, studies reported that cats were also infected with lambda (C.37), AY.3, B.1.1.7, and B.1.1.39 variants, all of which were from households that had experienced COVID‐19 infection 55–59 . These data suggest that SARS‐CoV‐2 can achieve cross‐species transmission from humans to cats.…”

Section: Natural Infections In Animalsmentioning

confidence: 84%

“…54 In addition, studies reported that cats were also infected with lambda (C.37), AY.3, B.1.1.7, and B.1.1.39 variants, all of which were from households that had experienced COVID-19 infection. [55][56][57][58][59] These data suggest that SARS-CoV-2 can achieve cross-species transmission from humans to cats. In addition to humans, the natural infection of cats with SARS-CoV-2 may also originate from other animals.…”

Section: Catsmentioning

confidence: 99%

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SARS‐CoV‐2 and natural infection in animals

Qiu

Liu

Sha

2022

Journal of Medical Virology

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Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is the causative agent of the novel coronavirus disease (COVID‐19) pandemic, which has caused serious challenges for public health systems worldwide. Due to the close relationship between animals and humans, confirmed transmission from humans to numerous animal species has been reported. Understanding the cross‐species transmission of SARS‐CoV‐2 and the infection and transmission dynamics of SARS‐CoV‐2 in different animals is crucial to control COVID‐19 and protect animal health. In this review, the possible animal origins of SARS‐CoV‐2 and animal species naturally susceptible to SARS‐CoV‐2 infection are discussed. Furthermore, this review categorizes the SARS‐CoV‐2 susceptible animals by families, so as to better understand the relationship between SARS‐CoV‐2 and animals.

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Section: Natural Infections In Animalsmentioning

confidence: 84%

Section: Catsmentioning

confidence: 99%

SARS‐CoV‐2 and natural infection in animals

Qiu

Liu

Sha

2022

Journal of Medical Virology

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“…VOI Lambda (C.37) was firstly identified in December 2020 in Peru and was defined by the WHO on June 14, 2021 [102] . This strain has high infectivity and immune-escape abilities and has been detected in North America, Europe, and the Middle East.…”

Section: Voi Strains and Their Mutation Hotpotsmentioning

confidence: 99%

“…VOI Lambda (C.37) was firstly identified in December 2020 in Peru and was defined by the WHO on June 14, 2021. [ 102 ] This strain has high infectivity and immune-escape abilities and has been detected in North America, Europe, and the Middle East. When it was firstly identified in Peru, VOI Lambda showed high infectivity and pathogenicity, and the mortality caused by this strain ranked in the top level worldwide in its first epidemic in August 2021.…”

Section: Voi Strains and Their Mutation Hotpotsmentioning

confidence: 99%

Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape

Dang

Ren

Wang

2022

Chinese Medical Journal

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The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.

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“…In general, natural infections reported in cats linked to multiple VOC resulted not only in subclinical outcomes but also in clinical infections, including signs of tiredness, lethargy, fever, ocular and nasal discharge, dyspnea, sneezing, cough, vomiting, diarrhea, anorexia, myocarditis, depression, arching of the back, lack of appetite, and weight loss [37][38][39][40][41]. The disparate clinical outcomes induced by different lineages of SARS-CoV-2 were demonstrated experimentally in cats, showing that the omicron lineage BA.1.1 represents a lower pathogenicity phenotype than the B.1 and Delta (B.1.1.529) lineages [37].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Potential Role of Cats (Felis catus) as Generators of Relevant SARS-CoV-2 Lineages during the Pandemic

Gomez-Romero,

Basurto-Alcantara,

Velazquez-Salinas

2023

Preprint

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Several questions regarding the evolution of SARS-CoV-2 remain poorly elucidated. One of these questions is the possible evolutionary impact of SARS-CoV-2 after the infection in domestic animals. In this study, we aimed to evaluate the potential role of cats as generators of relevant SARS-CoV-2 lineages during the pandemic. A total of 105 full-length genome viral sequences obtained from naturally infected cats during the pandemic were evaluated by distinct evolutionary algorithms. Analyses were enhanced, including a set of highly related SARS-CoV-2 sequences recovered from human populations. Our results showed the apparent high susceptibility of cats to the infection SARS-CoV-2 compared with other animal species. Evolutionary analyses indicated that the phylogenomic characteristics displayed by cat populations were influenced by the dominance of specific SARS-CoV-2 genetic groups affecting human populations. However, disparate dN/dS rates at some genes between populations recovered from cats and humans suggested that infection in these two species may suppose a different evolutionary constraint for SARS-CoV-2. Interestingly, the branch selection analysis showed evidence of the potential role of natural selection in the emergence of 5 distinct cat lineages during the pandemic. Although these lineages were apparently irrelevant to public health during the pandemic, our results suggested that additional studies are needed to understand the role of other animal species in the evolution of SARS-CoV-2 during the pandemic.

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First Detection and Genome Sequencing of SARS-CoV-2 Lambda (C.37) Variant in Symptomatic Domestic Cats in Lima, Peru

Cited by 7 publications

References 19 publications

SARS‐CoV‐2 and natural infection in animals

SARS‐CoV‐2 and natural infection in animals

Functional mutations of SARS-CoV-2: implications to viral transmission, pathogenicity and immune escape

Assessing the Potential Role of Cats (Felis catus) as Generators of Relevant SARS-CoV-2 Lineages during the Pandemic

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