First description of the pathogenicity of Babesia vogeli in experimentally infected dogs

Wang, Jiawei; Zhang, Jilei; Kelly, Patrick J.; Zheng, Xiaofeng; Li, Min; You, Jinfeng; Huang, Ke; Qiu, Haixiang; Wang, Yaoyao; Zhang, Rong; Li, Jianji; Dong, Junsheng; Feng, Yong; Zhou, Jinlin; Wang, Chengming

doi:10.1016/j.vetpar.2018.02.028

Cited by 23 publications

(24 citation statements)

References 62 publications

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“…In a survey conducted in Croatia, a higher prevalence of B. vogeli was observed in dogs with subclinical infection compared to those with clinical signs (BECK et al, 2009). The presence of B. vogeli in clinically healthy dogs in our study corroborates the available literature, which considers B. vogeli to be the least pathogenic strain that causes relatively mild disease, usually subclinical infection (BECK et al, 2009;IRWIN 2009;SCHOEMAN, 2009;IONITA et al, 2011;WANG et al, 2018).…”

supporting

confidence: 85%

“…and splenomegaly are common clinical signs of the disease, similar to infections caused by other Babesia spp. (AZMI et al, 2017;WANG et al, 2018).…”

mentioning

confidence: 99%

“…Considered to be less pathogenic, B. vogeli manifests subclinically or with only mild disease, exhibiting greater severity in splenectomized animals and puppies (SCHOEMAN, 2009;WANG et al, 2018). Of the infected dogs, seven (58.3%) exhibited some clinical sign at the time of data and sample collection including lymphadenomegaly, progressive weight loss, petechiae, alopecia, and/or conjunctivitis.…”

mentioning

confidence: 99%

“…Of the infected dogs, seven (58.3%) exhibited some clinical sign at the time of data and sample collection including lymphadenomegaly, progressive weight loss, petechiae, alopecia, and/or conjunctivitis. However, the stage of infection was unknown and other tick-borne diseases could not be excluded (WANG et al, 2018). The other three positive dogs -----------------------------------------------------------------------------Sex------------------------------------------------------------------------------ ------------------------------------------------------------------------Breed------------------------------------------------------------------------------- were subclinical.…”

mentioning

confidence: 99%

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Molecular prevalence and factors associated with Babesia vogeli infection in dogs in the Cerrado Mato-Grossense region of Brazil

et al. 2020

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Canine babesiosis is a common haemoparasitosis in Brazil. Caused by parasites of the genus Babesia, it is transmitted by ixodid ticks and affects domestic and wild canids. The objective of this study was to verify the prevalence of Babesia species (spp.) using molecular methods in dogs living in urban and rural areas of Cuiabá, Mato Grosso State, Brazil, and to identify the main factors associated with infection. A total of 407 samples from 407 dogs were evaluated using a polymerase chain reaction (PCR) technique, among which Babesia species (spp.) was amplified in 10 (2.5%). Although, no statistical association was found among the variables studied (p>0.05), greater positivity was observed in dogs<1 year of age, male sex, those with free access to the street, and the presence of ticks. PCR samples positive for Babesia spp. were submitted to sequencing and compared in GenBank and exhibited a high degree of similarity with Babesia vogeli sequences.

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supporting

confidence: 85%

“…and splenomegaly are common clinical signs of the disease, similar to infections caused by other Babesia spp. (AZMI et al, 2017;WANG et al, 2018).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Molecular prevalence and factors associated with Babesia vogeli infection in dogs in the Cerrado Mato-Grossense region of Brazil

et al. 2020

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“…One of the most common diseases in dogs is babesiosis. Areas of infection are found in the tropics (Jain et al, 2017;Ybañez et al, 2018), Mediterranean countries (Salem & Farag, 2014), Eastern (Davitkov et al, 2015;Bartnicki et al, 2017) and Western Europe (Eichenberger et al, 2016), Asia (Liu et al, 2016;Wang et al, 2018) and America (Di Cicco et al, 2012;Rojas et al, 2014). The analysis of recent publiccations proves that babesiosis in dogs occurs in almost all regions of Ukraine (in 18 of 24).…”

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confidence: 97%

Changes in erythrocytopoesis indices in dogs with babesiosis

Holovakha

Piddubnуak

Bakhur

et al. 2018

Regul. Mech. Biosyst.

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Babesiosis is a common disease in dogs. Babesia canis (Piana & Galli-Valerio, 1895) (Sporozoa, Babesiidae) causes the destruction of erythrocytes, resulting in hypotensive shock and total tissue damage due to lack of oxygen. Because of babesiosis, anemia develops in dogs, and in the first hours of the disease it is normocytic, normochromic and nonregenerative, and on the 2–3rd day of the course, macrocytic, hypochromic anemia with reticulocytosis develops. Scientists have studied the most common indicators of evaluation of erythrocytopoesis during babesiosis (the number of red blood cells, hemoglobin, hematocrit index, indices of “red” blood MCH and MCV), but the age structure of erythrocytes, their acid resistance and the ferrum-transferrin complex for this parasitic pathology have not been sufficiently studied. We carried out research on dogs of service breeds, which were divided into two groups: the first (6–18 months old, n = 10) and the second (2–8 years, n = 15). According to the conducted studies, in dogs of different age groups with babesiosis revealed oligocythemia with anisocytosis and poikilocytosis, oligochromia, decreased hematocrit index and macrocytosis. Significant changes in the morpho-functional state of erythrocytes in dogs of both groups have been revealed, in particular, changes in the population (age) composition of red blood cells: the number of “old” erythrocytes increases (they are rapidly destroyed), the “young” forms of red blood cells decrease and the time for their hemolysis is reduced. As a result of the study of the ferrum-transferrin complex in dogs with babesiosis in both groups, an increase in the level of free ferrum (UIBC) and a decrease in the saturation of transferrin with the trace element was found, which makes it impossible to form a hemoglobin molecule in the bone marrow.

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Molecular detection of pathogens in ticks associated with domestic animals from the Colombian Caribbean region

2020

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First description of the pathogenicity of Babesia vogeli in experimentally infected dogs

Cited by 23 publications

References 62 publications

Molecular prevalence and factors associated with Babesia vogeli infection in dogs in the Cerrado Mato-Grossense region of Brazil

Molecular prevalence and factors associated with Babesia vogeli infection in dogs in the Cerrado Mato-Grossense region of Brazil

Changes in erythrocytopoesis indices in dogs with babesiosis

Molecular detection of pathogens in ticks associated with domestic animals from the Colombian Caribbean region

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