Changes in erythrocytopoesis indices in dogs with babesiosis

Holovakha, Volodymyr; Piddubnуak, О. V.; Bakhur, Tetiana; Вовкотруб, Наталія Володимирівна; Antipov, Anatoliy; Anfiorova, M. V.; Gutyj, B. V.; Slivinska, L. G.; Kurdeko, O. P.; Macynovich, A. O.

doi:10.15421/021856

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…They block a huge amount of fibrinogen, increasing the risk of hypofibrinogenemic bleeding. They also increase the anticoagulant activity of the blood plasma (9,28,29,34,35).…”

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation Syndrome as a Complication in Acute Spontaneous Canine Babesiosis

Дубова

Фещенко

Bakhur

et al. 2020

Macedonian Veterinary Review

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The polyetiological syndrome of disseminated intravascular coagulation (DIC) is characterized by changes in patients’ hemostasis. The aim of the current research was to elucidate the main factors for the development of DIC syndrome during canine babesiosis, and to assess their correlation level. Dogs included in this study were of various breeds and sex, weighing 10-40 kg and aged 2-7 years. They were separated in two groups (n=50) according to their diagnosis to babesiosis. Oscillometry (blood pressure, pulse rate), vascular-platelet hemostasis, coagulogram, hematological, biochemical (fibrinogen, fibrin degradation product, soluble fibrin-monomer complex) and hemodynamic (circulating blood volume) assessment methods were used. The group of dogs positive on Babesia spp., had clear manifestation of DIC with 5-7% of the erythrocyte population being affected. DIC was manifested by a significant increase in soluble fibrin-monomer complex and fibrin degradation product (p<0.001), hypofibrinogenemia (p<0.001), thrombocytopenia (p<0.001), and an increase in indicators of spontaneous aggregation ability of platelets and red blood cells (p<0.001). Significant hemodynamic disorders were observed: a decrease in circulating blood volume, circulating erythrocytes volume (p<0.05), specific circulating blood volume and hematocrit value (p<0.001). The average blood pressure was reduced (p<0.001), and the Allgöwer’s shock index was increased 2 times (p<0.05). A shock of II degree (medium, subcompensated) was confirmed. Therefore, it can be concluded that acute spontaneous dogs’ babesiosis can be characterized by the occurrence of DIC in a consumption coagulopathy form, and shock of II degree. This condition renders the patients for emergency admission.

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“…They block a huge amount of fibrinogen, increasing the risk of hypofibrinogenemic bleeding. They also increase the anticoagulant activity of the blood plasma (9,28,29,34,35).…”

Section: Discussionmentioning

confidence: 99%

Disseminated Intravascular Coagulation Syndrome as a Complication in Acute Spontaneous Canine Babesiosis

Дубова

Фещенко

Bakhur

et al. 2020

Macedonian Veterinary Review

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“…Симптомокомплекс гострого спонтанного бабезіозу характеризує розвиток поліорганної недостатності внаслідок впливу патогенних чинників. Основний етіологічний стимул -це руйнівний вплив збудника на еритроцити (Solano-Gallego & Baneth, G., 2011;Köster et al, 2015;Holovakha et al, 2018).…”

Section: вступunclassified

Plasma replacement solutions in the intensive care unit of shock for acute spontaneous canine babesiosis

Дубова¹,

Фещенко²,

Goralska³

et al. 2020

SMLNUVMB

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The article presents the results of studies on the study of secondary processes that develop during acute spontaneous babesiosis in dogs, as well as on the use of infusion therapy with plasma substitutes for the development of shock as a complication of the underlying disease. It is shown that acute blood parasitic disease is accompanied by the development of moderate subcompensated shock, which determines the state of unstable equilibrium and the tendency to avalanche-like disorders due to the transition of the process to the decompensated phase. The basis for the diagnosis of the shock state was the establishment of the following hemodynamic and hemorheological changes: hypovolemia with a decrease of all blood components (shaped elements and plasma components) in the circulation, a significant decrease in the specific volume of circulating blood, hematocrit value, a significant increase in spontaneous aggregation of shaped blood elements (platelets and red blood cells), hypotension, an increase in the Alghöver shock index by almost 2 times. There was a significant deficit in the volume of circulating blood (the degree of blood loss), which was about 30 %. It is shown that the presence of a state of shock in the subcompensation stage poses a threat to the life of the animal in the event of transition to the terminal stage. In order to stop the development of shock, infusion therapy was used with the most common plasma–substituting solutions – Rheopolyglucin and Rheosorbylact at a dose of 5 ml/kg of body weight intravenously drip per day for 3 days. A comparative assessment of the effect of drugs on the correction of major hemodynamic and hemorheological shifts was carried out. It was found that Rheopolyglucin as a colloidal plasma substitute has a better effect on the normalization of hemodynamic disorders – hypovolemia and hypotension, and Rheosorbylact as a crystalloid plasma substitute turned out to be the best disaggregant and reducing agent of hemorheological disorders. Both drugs provided a complete recovery of hemodynamic and hemorheological parameters in 72 hours. As a result, it is recommended to use a combination of drugs with the priority of Rheopolyglucin in the first hours of treatment and combine it with an infusion of Rheosorbylact in subsequent days.

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“…The main mechanism of these reactions control is related to the chain of reversible redox reactions of metal ions, ascorbate, tocopherol, glutathione, and other substances (Martyshuk et al,2 021). In addition, the importance of these methods is especially important for the preservation of long-standing macromolecules of nucleic acids and proteins, some components of membranes (Holovakha et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Effect of Fenbenzyl and Fenbendazole on the Antioxidant Status in Dogs During Experimental Infection With Causative Agent of Toxocariasis

Stybel

Gutyj

Said

et al. 2021

Ukrainian journal of veterinary sciences

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The ar cle presents the results of studies of the effect of fenbenzyl and fenbendazole on the an oxidant status in dogs under the experimental infec on with a causa ve agent of toxocariasis. Experiments were performed on 18 dogs, two and four months old. Three groups of six animals in each were formed: control and two experimental. Puppies in all groups were experimentally infected with causa ve agent of toxocariasis at a dose of 5.000 embryonated Toxocara canis eggs per kg of body weight. The control group of dogs was as untreated control. Puppies of the first experimental group were fed with the drug fenbendazole at a dose of 150 mg per 3 kg of body weight once a day for three days in a single dose. Puppies of the second experimental group were fed with the drug fenbenzyl at a dose of 350 mg per 3 kg of body weight once a day for three days. While studying the ac vity of the enzyma c part of the an oxidant defense system, namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, as well as a non-enzyma c part: the level of reduced glutathione, an increase in the ac vity of these indicators was found in animals of experimental groups. It should be noted that the applica on of the drug fenbenzyl in infected dogs contributed to a be er normaliza on of the an oxidant system in animals than the use of the drug fenbendazole. The use of fenbenzyl in infected dogs contributed to a more likely increase in the an oxidant status in dogs of the second experimental group, as this drug includes milk thistle that exhibits an oxidant proper es due to the presence of silymarin, which restores damaged liver cells. Studies confirm the effec veness of the use of milk thistle in drug fenbenzyl in dogs with the development of toxocariasis infec on to ac vate the protec ve systems of their body.

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Changes in erythrocytopoesis indices in dogs with babesiosis

Cited by 10 publications

References 24 publications

Disseminated Intravascular Coagulation Syndrome as a Complication in Acute Spontaneous Canine Babesiosis

Disseminated Intravascular Coagulation Syndrome as a Complication in Acute Spontaneous Canine Babesiosis

Plasma replacement solutions in the intensive care unit of shock for acute spontaneous canine babesiosis

Effect of Fenbenzyl and Fenbendazole on the Antioxidant Status in Dogs During Experimental Infection With Causative Agent of Toxocariasis

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