UV nanosecond pulsed laser annealing (UV-NLA) is demonstrating clear benefits in emerging 3D-integrated electronic devices, where the allowed thermal budget is strictly limited to preserve underlying device performance. A possible drawback of UV-NLA is that melting a solid substrate covered by a dielectric layer, which can be found in typical electronic device structures, induces wrinkles on the surface and may be an issue for subsequent processes. In this study, UV-NLA is performed in SiO2/Si structures to systematically investigate the emergence of wrinkles. A classical analytical model shows good agreement with our experimental results if a fitting coefficient is involved. Interestingly, its value rapidly increases for a thinner SiO2 film, whereas it becomes closer to unity for a thicker SiO2 film. This might infer a possible discrepancy of the material properties taken from literature and those of real industrial thin SiO2 films. The degree of the initial SiO2 film stress being negligible compared to the SiO2 shear modulus, its impact on the growth of wrinkles is not significant in our experiment.