First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

Bonsdorff, Akseli; Sallinen, Ville; Räihä, Juulia; Ekstrand, Agneta; Nordin, Arno; Lempinen, Marko; Helanterä, Ilkka

doi:10.1111/ctr.14233

Cited by 7 publications

(18 citation statements)

References 22 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In detail, three‐quarters of affected patients developed a major complication. This is in line with the analysis of Bonsdorff et al., 50 underlining the role of plasma amylase as a prognostic marker for early postoperative complications after PT. They detected a strong correlation between plasma amylase levels on the first postoperative day and complications associated with the pancreas graft, especially rate of relaparotomy.…”

Section: Discussionsupporting

confidence: 90%

“…In detail, three-quarters of affected patients developed a major complication. This is in line with the analysis of Bonsdorff et al, 50 underlining the role of plasma amylase as a prognostic marker for early Relaparotomy for urinoma 1…”

Section: Discussionsupporting

confidence: 87%

“…They detected a strong correlation between plasma amylase levels on the first postoperative day and complications associated with the pancreas graft, especially rate of relaparotomy. Plasma amylase levels were even more precise compared to drain amylase values in dividing patients between high and low morbidity groups 50 . However, even if their median 90‐day CCI was comparable to ours, strikingly in their cohort no pancreas graft was lost to vascular complications including pancreas graft thrombosis 50 …”

Section: Discussionsupporting

confidence: 49%

“…50 However, even if their median 90-day CCI was comparable to ours, strikingly in their cohort no pancreas graft was lost to vascular complications including pancreas graft thrombosis. 50 This study has some limitations. First, we did not fully account for potentially significant changes in post-PT treatments over the study period, various immunosuppressive therapies and modifications of recipient and donor selection criteria.…”

Section: Surgical Wound Revision 1 Conversion Of Atrial Fibrillationsupporting

confidence: 50%

“…Plasma amylase levels were even more precise compared to drain amylase values in dividing patients between high and low morbidity groups. 50 However, even if their median 90-day CCI was comparable to ours, strikingly in their cohort no pancreas graft was lost to vascular complications including pancreas graft thrombosis. 50 This study has some limitations.…”

Section: Surgical Wound Revision 1 Conversion Of Atrial Fibrillationsupporting

confidence: 50%

See 4 more Smart Citations

Effect of donor pancreas extraction time on pancreas transplantation—a Swiss tertiary center experience

Kümmerli

Hügli

Jonas

et al. 2022

Clinical Transplantation

View full text Add to dashboard Cite

We aimed to assess the effect of donor pancreas extraction time (ET) on postoperative complications and graft function after pancreas transplantation (PT). We analyzed all consecutive donor pancreas procurements for the simultaneous pancreas and kidney transplantation (SPK) and the associated PT in a Swiss transplant center over a 20-year period. Pancreas ET was defined as the time from cold flush to static storage of the pancreas on ice. The primary endpoint was the effect of extraction time on surgical complications. Secondary endpoints comprised the effect of ET on graft function (insulin-free survival) and graft pancreatitis. Of 115 procured pancreas grafts the median donor pancreas ET was 65 min (IQR: 48-78 min). In multivariable analysis, ET did not negatively affect major complications (OR 1.41 [95% CI: .59-3.36]; p = .438) and insulin-free survival (HR 1.42 [95% CI: .55-3.63]; p = .459). The median CIT was 522 (441-608) min. CIT was associated with major complications (OR 2.51 [95% CI:1.11-5.68]; p = .027), but without impact on insulin-free survival (HR 1.94 [95% CI:.84-4.48]; p = .119). Patients with and without graft pancreatitis had no statistically significant differences in ET and CIT (p = .164 and p = .47, respectively). In multivariable analysis, Amylase levels > 270 U/L on postoperative day 1 were significantly associated with major complications ]; p = .040). Our results suggest that although no effect of ET on complications and graft function after PT was found, shorter CIT and less graft pancreatitis can have a positive impact on surgical complications. Results could possibly be influenced by the exceptional quality of the pancreas donors, with short travel distances and preservation times in Switzerland.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 49%

Section: Surgical Wound Revision 1 Conversion Of Atrial Fibrillationsupporting

confidence: 50%

Section: Surgical Wound Revision 1 Conversion Of Atrial Fibrillationsupporting

confidence: 50%

See 3 more Smart Citations

Effect of donor pancreas extraction time on pancreas transplantation—a Swiss tertiary center experience

Kümmerli

Hügli

Jonas

et al. 2022

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

Exploring definitions of graft pancreatitis following pancreas transplantation: A scoping review

Partelli,

Andreasi,

Tomajer

et al. 2024

Transplantation Reviews

View full text Add to dashboard Cite

Early Increases in Posttransplant Pancreatic Enzymes Are Associated With Surgical Complications But Not Graft Failure Among Pancreas Transplant Recipients

Parajuli¹,

Leverson

Kaufman

et al. 2022

Pancreas

View full text Add to dashboard Cite

ObjectivesThis study aimed to find the association between immediate postoperative increases in pancreatic enzymes and posttransplant complications among pancreas transplant recipients (PTRs).MethodsWe analyzed all PTRs transplanted at the University of Wisconsin between June 2009 and September 2018. Enzyme levels were presented as a ratio of absolute numbers to the upper limit of normal value, with value >1 considered as abnormal. We specifically evaluated bleeding, fluid collections, and thrombosis complications based on the amylase or lipase ratios on day 1 (Amylase1, Lipase1) and maximum ratios within 5 days of transplant (Amylasemax, Lipasemax). For early complications, we focused on technical complications that occurred within 90 days of transplant. For long-term outcomes, we assessed patient and graft survival, and rejections.ResultsThere were a total of 443 PTRs, 287 were simultaneous pancreas and kidney recipients, and 156 were solitary pancreas recipients. Higher Amylase1, Liplase1, Amylasemax, and Lipasemax were associated with an increase in early complications, mainly need for pancreatectomy, fluid collections, bleeding complications, or graft thrombosis, particularly in the solitary pancreas group.ConclusionsOur finding suggests that cases of early perioperative enzyme increase merit consideration for early imaging investigation to mitigate detrimental outcomes.

show abstract

First‐day plasma amylase detects patients at risk of complications after simultaneous pancreas‐kidney transplantation

Cited by 7 publications

References 22 publications

Effect of donor pancreas extraction time on pancreas transplantation—a Swiss tertiary center experience

Effect of donor pancreas extraction time on pancreas transplantation—a Swiss tertiary center experience

Exploring definitions of graft pancreatitis following pancreas transplantation: A scoping review

Early Increases in Posttransplant Pancreatic Enzymes Are Associated With Surgical Complications But Not Graft Failure Among Pancreas Transplant Recipients

Contact Info

Product

Resources

About