First certified reference material for cystatin C in human serum ERM-DA471/IFCC

Grubb, Anders; Blirup-Jensen, Søren; Lindström, Veronica; Schmidt, C. N. G.; Althaus, Harald; Zegers, Ingrid

doi:10.1515/cclm.2010.318

Cited by 320 publications

(217 citation statements)

References 10 publications

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…30 Serum cystatin C was measured on the Siemens BN100 Nephelometer using a particle-enhanced immunonephelometric assay (coefficient of variation of 2.7% and 5.5% for intra-and inter-assay imprecision, respectively), with assays traceable to International Federation for Clinical Chemists Working Group for the Standardization of Serum Cystatin C and the Institute for Reference Materials and Measurements certified reference materials. [31][32][33] GFR Estimation Equations eGFR was computed from equations developed by CKD-EPI, the Japanese group, BIS, and CAPA. 6,[15][16][17][18] Supplemental Table 8 shows these equations in detail.…”

Section: Laboratory Methodsmentioning

confidence: 99%

Comparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals

Fan

Levey

Gudnason

et al. 2015

Journal of the American Society of Nephrology

138

117

View full text Add to dashboard Cite

Current guidelines recommend reporting eGFR using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations unless other equations are more accurate, and recommend the combination of creatinine and cystatin C (eGFRcr-cys) as more accurate than either eGFRcr or eGFRcys alone. However, preferred equations and filtration markers in elderly individuals are debated. In 805 adults enrolled in the community-based Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we measured GFR (mGFR) using plasma clearance of iohexol, standardized creatinine and cystatin C, and eGFR using the CKD-EPI, Japanese, Berlin Initiative Study (BIS), and Caucasian and Asian pediatric and adult subjects (CAPA) equations. We evaluated equation performance using bias, precision, and two measures of accuracy. We first compared the Japanese, BIS, and CAPA equations with the CKD-EPI equations to determine the preferred equations, and then compared eGFRcr and eGFRcys with eGFRcr-cys using the preferred equations. Mean (SD) age was 80.3 (4.0) years. Median (25th, 75th) mGFR was 64 (52, 73) ml/min per 1.73 m 2 , and the prevalence of decreased GFR was 39% (95% confidence interval, 35.8 to 42.5). Among 24 comparisons with the other equations, CKD-EPI equations performed better in 9, similar in 13, and worse in 2. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr in four metrics, better than eGFRcys in two metrics, and similar to eGFRcys in two metrics. In conclusion, neither the Japanese, BIS, nor CAPA equations were superior to the CKD-EPI equations in this cohort of community-dwelling elderly individuals. Using the CKD-EPI equations, eGFRcr-cys performed better than eGFRcr or eGFRcys.

show abstract

Section: Laboratory Methodsmentioning

confidence: 99%

Comparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals

Fan

Levey

Gudnason

et al. 2015

Journal of the American Society of Nephrology

138

117

View full text Add to dashboard Cite

show abstract

“…Serum creatinine was measured using a creatinase enzymatic method on a Roche Modular P Chemistry Analyzer (Roche Diagnostics, Indianapolis, Indiana) and standardized to isotope-dilution mass spectrometry. Serum cystatin C level measured by a turbidimetric method (Gentian AS, Moss, Norway), calibrated and standardized to International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) reference 25 .…”

Section: Methodsmentioning

confidence: 99%

Frailty, Kidney Function, and Polypharmacy: The Atherosclerosis Risk in Communities (ARIC) Study

Ballew

Chen

Daya

et al. 2017

American Journal of Kidney Diseases

View full text Add to dashboard Cite

Background Frail individuals are at increased risk for poor outcomes, including adverse drug events. Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing; however, creatinine-based measures of kidney function may be biased in frail individuals. Study Design Observational study. Setting & Participants 4,987 community-dwelling older men and women with complete data who participated in visit 5 of the Atherosclerosis Risk in Communities (ARIC) Study (2011–2013). Predictor Kidney measures included glomerular filtration rate (GFR) estimated using serum creatinine (eGFRcr) and serum cystatin C (eGFRcys) and urine albumin-creatinine ratio (ACR). Outcomes Frailty, defined using established criteria of 3 or more frailty characteristics (weight loss, slowness, exhaustion, weakness, and low physical activity). Results In total, 341 participants (7%) were classified as frail, 1475 (30%) had eGFRcr <60 ml/min/1.73 m2, 2480 (50%) had eGFRcys <60 ml/min/1.73 m2, and 1006 (20%) had albuminuria ≥30 mg/g. Among frail participants, prevalences of eGFRcr and eGFRcys <60 ml/min/1.73 m2 were 45% and 77%, respectively. Adjusted for covariates, frailty showed a moderate association with eGFRcr and a strong association with eGFRcys and ACR. Frail individuals with eGFRcr 60–<75 ml/min/1.73 m2 were frequently reclassified to lower eGFR categories using eGFRcys (49% to 45–<60, 32% to 30–<45, and 3% to <30 ml/min/1.73 m2). Hyperpolypharmacy (taking ≥10 classes of medications) was more common in frail individuals (54% vs 38% of non-frail), including classes requiring kidney clearance (e.g., digoxin) and associated with falls and subsequent complications (e.g., hypnotic/sedatives, anticoagulants). Limitations Cross-sectional study design. Conclusions Frail individuals had a high prevalence of reduce kidney function, with large discrepancies when reduced kidney function was classified by eGFRcys versus eGFRcr. Given the substantial medication burden and uncertainty in CKD classification, confirmation of kidney function with alternative biomarkers may be warranted to ensure careful prescribing practices in this vulnerable population.

show abstract

“…Plasma Cystatin C (CysC) was measured using the N Latex cystatin C assay on the Behring Nephelometer II (Siemens Healthcare Diagnostics Products GmbH, Marburg, Germany) (intra-assay coefficient of variation [CV]: 1.4%; inter-assay CV: 5.4%) and was standardized according to the ERM-DA471/IFCC reference material. 25 Creatinine was measured in serum (Scr) using the rateblanked compensated Jaffe technique (Modular P and Cobas 6000, Roche Diagnostics GmbH, Mannheim, Germany).…”

Section: Drug and Biochemical Assaysmentioning

confidence: 99%

Dose optimization of piperacillin/tazobactam in critically ill children

Cock¹,

Dijkman

Jaeger

et al. 2017

Journal of Antimicrobial Chemotherapy

View full text Add to dashboard Cite

Running title: Paediatric piperacillin/tazobactam dose rationale SynopsisObjectives. The aim of this study was to characterize the population pharmacokinetics of piperacillin and tazobactam in critically ill infants and children, in order to develop an evidence-based dosing regimen.Patients and Methods. This pharmacokinetic study enrolled patients admitted to the paediatric ICU for whom intravenous piperacillin/tazobactam (8:1 ratio) was indicated (75 mg/kg q6h based on piperacillin). Piperacillin/tazobactam concentrations were measured by a liquid chromatography-tandem mass spectrometry method. Pharmacokinetic data was analysed using nonlinear mixed effects modelling.Results. Piperacillin and tazobactam blood samples were collected from 47 patients (median age: 2.83 years; range: 2 months -15 years). Piperacillin and tazobactam disposition was best described by a two-compartment model which included allometric scaling and a maturation function to account for the effect of growth and age. Mean clearance estimates for piperacillin and tazobactam were 4.00 L/h and 3.01 L/h for a child of 14 kg. Monte Carlo simulations showed that an intermittent infusion of 75 mg/kg (based on piperacillin) q4h over 2 hours, 100 mg/kg q4h given over 1 hour or a loading dose of 75 mg/kg followed by a continuous infusion of 300 mg/kg/24h were minimally required to achieve the therapeutic targets for piperacillin (60 % fT>MIC>16 mg/L). Conclusion. Standard intermittent dosing regimens do not ensure optimalpiperacillin/tazobactam exposure in critically ill patients, thereby risking treatment failure. The use of a loading dose followed by a continuous infusion is recommended for treatment of severe infections in children >2 months of age.

show abstract

First certified reference material for cystatin C in human serum ERM-DA471/IFCC

Cited by 320 publications

References 10 publications

Comparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals

Comparing GFR Estimating Equations Using Cystatin C and Creatinine in Elderly Individuals

Frailty, Kidney Function, and Polypharmacy: The Atherosclerosis Risk in Communities (ARIC) Study

Dose optimization of piperacillin/tazobactam in critically ill children

Contact Info

Product

Resources

About