First case report of sepsis caused by Mycobacterium wolinskyi in chronic myelogenous leukemia

Ohno, Tatsuharu; Kishimoto, Wataru; Chihara, Dai; Sakamoto, Takashi; Arimoto-Miyamoto, Kazue; Takeoka, Tomoharu; Tsuji, Masaaki; Kida, Kaneyuki; Ohkusu, Kiyofumi; Ezaki, Takayuki

doi:10.1016/j.diagmicrobio.2008.07.017

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Contrary to several reported cases of SSTI caused by other NTM species [6-10], previously reported cases of M. wonlinskyi -related SSTI mostly described incidences following surgical procedures including hip prosthesis, peritoneal dialysis, transplantation, and heart surgery and posttraumatic events [3,11-13]. Infections have also been observed in immunocompromised patients [14,15] and in some cases of tissue necrosis involving subjacent bone [1]. However, M. wolinskyi infection complicating facial cosmetic procedure has not hitherto been reported, although there are increasing reports of SSTI caused by other RGM species involving cosmetic therapy such as M. fortuitum, M. abscessus, M. jacuzzi and M .…”

Section: Discussionmentioning

confidence: 99%

Facial skin and soft tissue infection caused by Mycobacterium wolinskyi associated with cosmetic procedures

et al. 2013

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BackgroundMycobacteirum wolinskyi is a member of the Mycobacterium smegmatis group, which is less frequently found in clinical settings than other nontuberculous mycobacterium (NTM) species. However, its clinical significance has recently increased in opportunistic infections. This case is the first report of facial skin and soft tissue infection by M. wolinskyi complicating cosmetic procedures.Case presentationA 56-year-old Asian female patient with a history of receiving multiple facial cosmetic procedures over the preceding 2 years was admitted to our institution with swelling, local pain, and erythema on the right cheek. Mycobacteirum fortuitum complex isolated from a pus culture was identified as M. wolinskyi by rpoB sequencing. Metallic foreign bodies and abscess were detected by radiologic imaging. The pus was incised and drained. Treatment comprised clarithromycin (500 mg every 12 h), amikacin (200 mg every 8 h), and ciprofloxacin (400 mg every 6 h).ConclusionWe report the first case of facial skin and soft tissue infection with M. wolinskyi after multiple cosmetic procedures of filler injection and laser lipolysis. Increased occurrence of NTM infection in nosocomial settings suggests the importance of appropriate treatment including culturing and rpoB gene sequencing when patients who have undergone cosmetic procedures display symptoms and signs of soft tissue infection indicative of NTM infection.

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Section: Discussionmentioning

confidence: 99%

Facial skin and soft tissue infection caused by Mycobacterium wolinskyi associated with cosmetic procedures

et al. 2013

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“…Previously, it would be identified as M. smegmatis group without further species differentiation. With the advance of molecular identification techniques, M. wolinskyi is increasingly recognized in clinical specimens .…”

Section: Discussionmentioning

confidence: 99%

“…The antimicrobial susceptibility pattern often differs among RGM species . These differences are important not only for therapeutic purposes but also for the identification of the organism.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium wolinskyi Infection Confirmed by rpoB Gene Sequencing

Jeong

Seo

Kim

et al. 2012

Clinical Laboratory Analysis

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Identification of rapidly growing mycobacteria (RGM) is problematic because there are many taxonomic changes. 16S rRNA gene is commonly used to identify Mycobacterium species, but alternative gene targets have been introduced for more accurate identification. We report a rare case of a prosthetic knee infection due to Mycobacterium wolinskyi. The isolate was not identified by 16S rRNA gene sequencing alone and substantially confirmed by rpoB gene sequencing. The identification was delayed because our laboratory did not routinely identify RGM to the species level. Simultaneous sequencing of both 16S rRNA and rpoB genes will allow rapid and accurate identification of M. wolinskyi isolates.

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“…Mycobacterium wolinskyi is an uncommon, rapid growing NTM previously belonging to the Mycobacterium smegmatis group ( 2 ). Although fewer than 30 clinical cases have been described worldwide, M. wolinskyi is associated with bacteremia ( 3 , 4 ), peritonitis ( 5 ), infections associated with implants/prostheses ( 6 – 8 ), and postsurgical skin and soft tissue infections ( 9 – 11 ).…”

Section: Genome Announcementmentioning

confidence: 99%

Draft Genome Sequence of Mycobacterium wolinskyi , a Rapid-Growing Species of Nontuberculous Mycobacteria

et al. 2016

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First case report of sepsis caused by Mycobacterium wolinskyi in chronic myelogenous leukemia

Cited by 10 publications

References 8 publications

Facial skin and soft tissue infection caused by Mycobacterium wolinskyi associated with cosmetic procedures

Facial skin and soft tissue infection caused by Mycobacterium wolinskyi associated with cosmetic procedures

Mycobacterium wolinskyi Infection Confirmed by rpoB Gene Sequencing

Draft Genome Sequence of Mycobacterium wolinskyi , a Rapid-Growing Species of Nontuberculous Mycobacteria

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