First case report of non‐human primates (<i>Alouatta clamitans</i>) with the hypervirulent <i>Klebsiella pneumoniae</i> serotype K1 strain ST 23: A possible emerging wildlife pathogen

Anzai, Eleine Kuroki; Júnior, Júlio César de Souza; Peruchi, Amanda Rezende; Fonseca, Juliana Mello; Gumpl, Elke Kreuscher; Pignatari, Antônio Carlos Campos; Hirano, Zelinda Maria Braga; Silveira, Alessandro Conrado de Oliveira

doi:10.1111/jmp.12296

Cited by 16 publications

(16 citation statements)

References 43 publications

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“…Clinically important K. pneumoniae lineages have been isolated from specific non--human sources ( Fig 3B); e.g. ESBL ST15 in cats and dogs [60][61][62], and hypervirulent ST23 or ST25 in horses, non--human primates and pigs [44,63,64]. Genomic comparisons of K. pneumoniae from diverse sources are rare but show little evidence of segregation between niches: in a global diversity study, 59 bovine isolates were distributed around the species phylogeny comprising mostly human isolates [9]; and a comparison of ESBL isolates from Thai hospitals and a local canal system indicated phylogenetic intermingling [65].…”

Section: Ecological Rangementioning

confidence: 99%

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Wyres

2018

Preprint

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Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae’s contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.

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Section: Ecological Rangementioning

confidence: 99%

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Wyres

2018

Preprint

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“…Clinically important K. pneumoniae lineages have been isolated from specific non--human sources (Fig 3B); e.g. ESBL ST15 in cats and dogs [60][61][62], and hypervirulent ST23 or ST25 in horses, non--human primates and pigs [44,63,64]. Genomic comparisons of K. pneumoniae from diverse sources are rare but show little evidence of segregation between niches: in a global diversity study, 59 bovine isolates were distributed around the species phylogeny comprising mostly human isolates [9]; and a comparison of ESBL isolates from Thai hospitals and a local canal system indicated phylogenetic intermingling [65].…”

Section: Ecological Rangementioning

confidence: 99%

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Wyres

Holt

2018

Preprint

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Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem--resistance genes KPC, OXA--48 and NDM--1). Whilst K. pneumoniae's contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.

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“…9 Recently, infectious diseases such as yellow fever have also been mentioned as a cause of decline in the population. [10][11][12][13][14] Howlers are considered a yellow fever sentinel species, indicating the circulation of the virus through epizootics. 15 Although ecological and behavioral aspects of these species have been broadly studied, [16][17][18][19][20][21][22][23] information on physiological parameters is scarce in the literature.…”

Section: Introductionmentioning

confidence: 99%

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

Gonçalves

Souza

Pitz

et al. 2019

J of Medical Primatology

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Background: Physiological values reflect the health condition and responses of individuals to handling in captivity. The aim of this study was to establish hematological and serum biochemistry parameters of clinically healthy animals of the Alouatta guariba clamitans subspecies. Methods:We collected blood samples from adult males and females kept at the Center for Biological Research of Indaial after chemical containment with 3.9 mg/kg of tiletamine hydrochloride and zolazepam.Results: Significant differences between males and females were found in the levels of erythrocytes, hemoglobin, hematocrit, lymphocytes, neutrophils, platelets, mean corpuscular hemoglobin concentration (MCHC), and gamma-glutamyltranspeptidase (GGT). Conclusions: Our results suggest the existence of sexual dimorphism in some physiological parameters of A guariba clamitans. The parameters reported herein can be used as reference values for other populations kept under similar conditions. K E Y W O R D S Alouatta guariba clamitans, blood biochemistry, electrophoresis, hematology, neotropical primates, reference values, serum proteinogram How to cite this article: Gonçalves GHP, de Souza Junior JC, Pitz HS, Peruchi AR, Branco FS, Hirano ZMB. Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil. J Med Primatol. 2019;48:313-319. https ://doi.

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First case report of non‐human primates (Alouatta clamitans) with the hypervirulent Klebsiella pneumoniae serotype K1 strain ST 23: A possible emerging wildlife pathogen

Abstract: This is the first case report of NHPs caused by K. pneumoniae displaying a hypermucoviscosity phenotype and belonging to capsular serotypes K1 and ST23.

Cited by 16 publications

References 43 publications

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

Hematological and serum biochemistry data on southern brown howler monkeys (Alouatta guariba clamitans) in captivity in Brazil

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