First case of invasive Magnusiomyces capitatus infection in Slovakia

Abstract

Magnusiomyces capitatus (previously known as Geotrichum capitatum or Blastoschizomyces capitatus or Trichosporon capitatum) is a rare cause of fungal infection in immunocompromised patients. Most of these cases (87%) have been reported from the Mediterranean region, as it is extremely rare to recognize it in other regions. Here we report a first case of disseminated M. capitatus infection in Slovakia. The patient – 19 year old woman with myelodysplastic syndrome was diagnosed with M. capitatus fungemia after allogeneic stem cell transplantation. The infection occurred despite antifungal prophylaxis with micafungin, which was in vitro sensitive to the yeast. The treatment according to minimal inhibitory concentrations (micafungin, voriconazol) and granulocyte transfusions were administered. M. capitatus was cleared out from the bloodstream. However, patient died of multiple organ failure. Autopsy showed multiple lesions in organs, but did not prove presence of yeast by histopathology. M. capitatus was confirmed by polymerase chain reaction from all tested organs: heart, brain, lungs, spleen, liver and kidneys. We present the post mortem pictures showing the yeast lesions in affected organs. 2012 Elsevier Ltd. All rights reserved.

Compostos Bioativos Em Frutos De Acerolas Submetidos Ao Branqueamento Por Vapor E Congelamento

“…Quanto a determinação do pH, não houve diferença significativa entre as amostras avaliadas. Xavier et al (2008), afirmam que UH e pH são influenciados pelo tempo de estocagem da amostra, sendo nos primeiros 5 dias o mais preponderante aumento. Neste experimento, o aumento de pH, mesmo nas amostras com as melhores medidas de UH, sugere que a variação de pH não ocorreu devido ao maior tempo de estocagemjá que este fator afetaria todos os parâmetros de qualidade -, mas pela exposição dos ovos às altas temperaturas e umidade, durante a estocagem, fatores estes que afetam rapidamente o pH.…”

Magnusiomyces capitatus fungemia: The value of direct microscopy in early diagnosis

“…This report is noteworthy in that it conveys three important messages, firstly, M. capitatus fungemia occurred in non-neutropenic and non-hematologic patients, secondly, initial diagnosis was made by characteristic morphological feature of the yeast in blood cultures, and thirdly, it emphasizes the need of prior identification and susceptibility testing since arthroconidial yeast-like fungi are intrinsically resistant to echinocandins. M. capitatus (anamorph: Saprochaete capitate ) is an emerging yeast pathogen associated with considerable mortality in immunocompromised patients [2,3,[9], [10], [11]] (Mazzacato et al, 2015; Tanuskova et al, 2017; Martino et al, 2004; Girmenia et al, 2005, Garcia-Ruiz et al, 2013). The species has acquired considerable clinical significance since several cases of breakthrough M. capitatus fungemia, have recently been reported in patients receiving echinocandins [12,13].…”

“…In literature, it has been variedly described as Blastoschizomyces capitatus , Geotrichum capitatum , Trichosporon capitatum and Dispodascus capitatus [1] (de Hoog et al, 2004). M. capitatus can cause invasive infections among immunosuppressed patients especially those with hematologic disorders [2,3] (Mazzcato et al, 2015; Tanuskova et al, 2017). It can also infect non-neutropenic and immunocompetent patients [4,5] (Shah, 2017; D'Assumpcao et al, 2018).…”

A Case of Magnusiomyces capitatus Peritonitis Without Underlying Malignancies

“…Magnusiomyces capitatus , previously known as Geotrichum capitatum, Dipodascus capitatus, Trichosporon captiatum, Saprochaete capitata , or Blastoschizomyces capitatus , 1 is a rare cause of fungal infection in immunocompromised patients, mainly seen in hematological malignancies. 2 - 17 M capitatus is extremely rare in immunocompetent patients, as it is part of normal human microbial flora. 18 Presented here is a case of peritonitis infection with M capitatus without underlying malignancies.…”