A Case of Magnusiomyces capitatus Peritonitis Without Underlying Malignancies

Abstract

Magnusiomyces capitatus is a rare cause of fungal infection in immunocompromised patients, mainly seen in hematological malignancies. M capitatus infections are extremely rare in immunocompetent patients, as it is part of normal human microbial flora. We are presenting an extremely rare case of M capitatus peritonitis in an otherwise immunocompetent patient who suffered from gastrointestinal leakage due to pancreatitis. Fungal identification was performed at reference laboratory by phenotypic characteristics and DNA sequencing of target internal transcribed spacer region of the rRNA gene and the D1-D2 domain of the large-subunit rRNA gene and susceptibility testing by Clinical and Laboratory Standards Institute guidelines (document M27-S4) broth dilution method. He was successfully treated with a combination of surgical repair and voriconazole single therapy.

Infection With Saprochaete Clavata in Children After Hematopoietic Cell Transplantation

“…Besides antifungals, it is essential to remove catheters and other potential sources of infection (e.g. drainage of an empyema or retroperitoneal fluid collection) 27,28,44 . Reduction of immunosuppression and use of granulocyte colony-stimulating factor (G-CSF) tends to be helpful in eliminating the infection in some patients 23 .…”

“…drainage of an empyema or retroperitoneal fluid collection). 27,28,44 Reduction of immunosuppression and use of granulocyte colony-stimulating factor (G-CSF) tends to be helpful in eliminating the infection in some patients. 23 There is no specific data on secondary prevention of Saprochaete spp.…”

Invasive Fungal Infection Caused by Magnusiomyces capitatus in an Immunocompromised Pediatric Patient with Acute Lymphoblastic Leukemia in Mexico City: A Case Report

“…They have also been reported in other areas of Europe (Slovakia, Switzerland, and the Czech Republic) [ 4 ] and in Asia (India, Nepal, Kuwait, and China) [ 21 , 22 , 23 ]. In the Americas, M. capitatus was recently isolated from an alcoholic male patient in the United States [ 24 ].…”

“…Therefore, phylogenetic reconstruction methods were employed for the characterization of the fungal strain. Molecular identification and phylogeny have been used previously for the detection of M. capitatus and its differentiation from closely related species such as S. clavata [ 24 , 25 , 26 ]. These techniques were instrumental for recognizing M. capitatus ENCB-HI-834 as the agent of the present systemic infection.…”

Magnusiomyces capitatus fungemia: The value of direct microscopy in early diagnosis

“…M. capitatus can cause invasive infections among immunosuppressed patients especially those with hematologic disorders [2,3] (Mazzcato et al, 2015; Tanuskova et al, 2017). It can also infect non-neutropenic and immunocompetent patients [4,5] (Shah, 2017; D'Assumpcao et al, 2018). In immunocompromised patients, infections with M. capitatus are associated with increased risk of dissemination and high rates of mortality.…”