First- and second-generation quinolone antibacterial drugs interacting with zinc(II): Structure and biological perspectives

Tarushi, Alketa; Lafazanis, Konstantinos; Kljun, Jakob; Turel, Iztok; Pantazaki, Αnastasia A.; Psomas, George; Kessissoglou, Dimitris P.

doi:10.1016/j.jinorgbio.2012.12.009

Cited by 103 publications

(84 citation statements)

References 78 publications

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“…For complex (4), the hydrogen atoms from the py- observed the same behavior with another zinc compound synthesized with a ligand which also contains pyridine and phenol groups; those studies seem to indicate the presence of different isomers in solution [9]. The aliphatic region is dominated by two intense broad signals at 3.95 ppm and 4.08 ppm, which are associated with the methylenic hydrogen atoms.…”

Section: Ir and Nmr Spectrasupporting

confidence: 55%

“…In 2012, Muthmary and co-workers reported the cytotoxicity of dizinc(II) complexes for human hepatoma HepG2 cancer cells, where these compounds were able to induce caspase-dependent apoptosis [8]. In 2013, Kessissoglou and co-workers reported the antimicrobial activity of zinc(II) complexes on five different microorganisms with IC 50 values in the range of 1-4 µg.ml -1 [9]. Another established application for a zinc compound is as an anti-dandruff agent; zinc pyrithione (ZPT) is an antimicrobial compound used since 1960 in anti-dandruff shampoos and also anti-fouling paints [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin

Fields¹,

Reeve

Bartholomaeus

et al. 2014

Food and Chemical Toxicology

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Synthesis, characterization, antibacterial and antitumoral activities of mononuclear zinc complexes containing tridentade amine based ligands with N3 or N2O donor groups, Inorganica Chimica Acta (2014), doi: http://dx.doi.org/10.1016/j.ica. 2014.02.040 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Ir and Nmr Spectrasupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin

Fields¹,

Reeve

Bartholomaeus

et al. 2014

Food and Chemical Toxicology

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“…The displacement of EB by synthesized complexes at 610 nm confirmed the intercalative binding mode for complex to DNA interaction. The extent of fluorescence intensity quenching is the measure of the strength of binding between DNA base pair and complexes . Quenching can occur by different mechanisms.…”

Section: Resultsmentioning

confidence: 99%

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

et al. 2019

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Novel palladium(II) complexes (7a–7e) of substituted quinoline derivatives were synthesized. The complexes were characterized using various techniques such as thermogravimetric analysis (TGA), elemental analysis, conductance measurement, mass, absorption, infra‐red (IR), 1H NMR, 13C NMR and energy‐dispersive X‐ray spectroscopy (EDX). Complexes for herring sperm DNA (HS DNA) binding were explored and absorption titration and the binding constant (Kb) as well as Gibb's free energy were evaluated. Complex 7d exhibited the highest binding constant, therefore the thermodynamic parameters of 7d at different temperatures were evaluated. To support the results of the absorption titration, fluorescence titration, viscosity measurement and molecular docking studies were performed. The fluorescence quenching data as evaluated from Stern–Volmer equation were used to calculate KSV, Kf and the number of binding sites. The results of all these studies were in good agreement with the absorption study. DNA electrophoretic mobility was performed to explore the possible application of metal complexes as artificial metallonucleases. The antibacterial activity of the complexes was accessed against different pathogenic bacteria and cytotoxicity was measured using brine shrimp and S. pombe.

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“…The addition of complexes (6a‐6f) at diverse r‐ values resulted in a significant gradually decrease of the intensity of the emission band of the DNA–EB system at 610 nm indicating the competition of the Pt II complexes with EB in binding to DNA. The observed quenching of DNA–EB fluorescence by the compounds proposes that the complexes can significantly displace to ethidium bromide (EB) from the DNA–EB system, thus the illuminating the partial interaction with HS‐DNA by the intercalative mode . The linear Stern–Volmer plots of DNA–EB for the complexes show that the quenching of EB–DNA by the complexes is in better agreement (r = 3.33) with the linear Stern–Volmer quenching equation proving that the addition of EB from EB–DNA by each compound result in a decrease in the fluorescence intensity .…”

Section: Resultsmentioning

confidence: 83%

Design, synthesis, pharmacological evaluation and DNA interaction studies of binuclear Pt(II) complexes with pyrazolo[1,5‐a]pyrimidine scaffold

Lunagariya

Thakor

Waghela

et al. 2018

Applied Organom Chemis

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Substituted pyrazolo[1,5-a]pyrimidine ligands were synthesized by cyclization, using 3-(thiophen-2-yl)-1H-pyrazol-5-amine with substituted enones (3-phenyl-1-(pyridin-2-yl)prop-2-en-1-one) in presence of KOH and DMF as solvent to form cyclic aromatic compounds. The substituted pyrazolo[1,5-a] pyrimidine based binuclear Pt II complexes containing neutral tetradentated ligands have general formula [Pt 2 (5a-5f)Cl 4 ], (where, (5a -5f) = pyrazolo[1,5-a] pyrimidine ligand). This compounds were characterized by physicochemical and spectroscopic method like elemental analyses, UV-Visible, FT-IR, EDX, TGA, molar conductivity, magnetic susceptibility measurements, mass spectroscopy, 1 H and 13 C NMR method. The square planar geometry was predicted by electronic spectral study. All Pt II compounds were evaluated by antimicrobial assay, in vitro brine shrimp assay, in vivo cellular level bioassay using S. Pombe cells and anti-tuberculosis study. LC 50 (50% lethal concentration) values of compounds are observed between 6.450 -102.07 μg/mL. UV-vis absorption titration, competitive displacement assay, molecular docking and viscosity measurement were carried out to examine the binding type and binding strength of complexes. The binding studies suggest partial intercalative binding mode of the complexes and the observed binding constant (K b ) values are found in the order of 6d > 6b > 6c > 6a > 6e > 6 f. The anti-proliferative cytotoxicity of the synthesized Pt II complexes (6a-6f) were tested against the HCT-116 (Human Colorectal Carcinoma) cancer cell line.

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First- and second-generation quinolone antibacterial drugs interacting with zinc(II): Structure and biological perspectives

Cited by 103 publications

References 78 publications

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin

Fluorescence and absorption studies of DNA–Pd(II) complex interaction: Synthesis, spectroanalytical investigations and biological activities

Design, synthesis, pharmacological evaluation and DNA interaction studies of binuclear Pt(II) complexes with pyrazolo[1,5‐a]pyrimidine scaffold

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