First-aid with warm water delays burn progression and increases skin survival

Tobalem, Mickaël; Harder, Yves; Tschanz, Elizabeth R.; Speidel, Victor; Pittet‐Cuénod, Brigitte; Wettstein, Reto

doi:10.1016/j.bjps.2012.09.014

Cited by 28 publications

(19 citation statements)

References 34 publications

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“…Punch skin biopsies were taken from the center of burns at 72 hours post injury to evaluate burn progression during the first 3 days post injury. 37 , 38 Biopsies were fixed in buffered formalin and embedded in paraffin. Ten-μm- sections were stained with Masson’s Trichrome, a stain favorable in partial burns because of its magenta-red coloring of denatured collagen, indicative of the extent of partial burn, whereas rapid FT burns are characterized by a glass-like fixed appearance.…”

Section: Methodsmentioning

confidence: 99%

Hyperspectral Imaging for Burn Depth Assessment in an Animal Model

Chin¹,

Babchenko

Lujan-Hernandez

et al. 2015

Plastic and Reconstructive Surgery - Global Open

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Background:Differentiating between superficial and deep-dermal (DD) burns remains challenging. Superficial-dermal burns heal with conservative treatment; DD burns often require excision and skin grafting. Decision of surgical treatment is often delayed until burn depth is definitively identified. This study’s aim is to assess the ability of hyperspectral imaging (HSI) to differentiate burn depth.Methods:Thermal injury of graded severity was generated on the dorsum of hairless mice with a heated brass rod. Perfusion and oxygenation parameters of injured skin were measured with HSI, a noninvasive method of diffuse reflectance spectroscopy, at 2 minutes, 1, 24, 48 and 72 hours after wounding. Burn depth was measured histologically in 12 mice from each burn group (n = 72) at 72 hours.Results:Three levels of burn depth were verified histologically: intermediate-dermal (ID), DD, and full-thickness. At 24 hours post injury, total hemoglobin (tHb) increased by 67% and 16% in ID and DD burns, respectively. In contrast, tHb decreased to 36% of its original levels in full-thickness burns. Differences in deoxygenated and tHb among all groups were significant (P < 0.001) at 24 hours post injury.Conclusions:HSI was able to differentiate among 3 discrete levels of burn injury. This is likely because of its correlation with skin perfusion: superficial burn injury causes an inflammatory response and increased perfusion to the burn site, whereas deeper burns destroy the dermal microvasculature and a decrease in perfusion follows. This study supports further investigation of HSI in early burn depth assessment.

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Section: Methodsmentioning

confidence: 99%

Hyperspectral Imaging for Burn Depth Assessment in an Animal Model

Chin¹,

Babchenko

Lujan-Hernandez

et al. 2015

Plastic and Reconstructive Surgery - Global Open

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“…I den senere tid er det også blitt gjennomført forskning på førstehjelpsfaktorer som påvirker brannskader (15) og behandling av skadene (16). Wright og medarbeidere oppsummerer nyere forskning som viser at vannkjøling fungerer bra og at effekten går langt utover ren termisk kjøling (17).…”

Section: Forskningsresultaterunclassified

Med livet som innsats

Log¹

2016

Tidsskriftet

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“…They demonstrate that activation of this alternative pathway using the peptide ARA290 lessens TNF-α secretion by immune cells, decreases microvascular thrombosis, and preserves the deep dermal vascular network in burn wounds, subsequently reducing burn wound conversion. A recent study by Yuhua et al similarly showed reduced burn wound progression when secondary burns were treated with Poloxamer 188 (P188), a copolymer suggested to reduce microvascular stasis and decrease PMN ROS generation [79]. Both of these studies emphasize the effects of poor perfusion, microthrombosis, and pro-inflammatory mediators in burn wound conversion.…”

Section: Discussionmentioning

confidence: 99%

Current concepts on burn wound conversion—A review of recent advances in understanding the secondary progressions of burns

Salibian

Rosario

Severo

et al. 2016

Burns

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Burn wound conversion describes the process by which superficial partial thickness burns convert into deeper burns necessitating surgical intervention. Fully understanding and thus controlling this phenomenon continues to defy burn surgeons. However, potentially guiding burn wound progression so as to obviate the need for surgery while still bringing about healing with limited scarring is the major unmet challenge. Comprehending the pathophysiologic background contributing to deeper progression of these burns is an essential prerequisite to planning any intervention. In this study, a review of articles examining burn wound progression over the last five years was conducted to analyze trends in recent burn progression research, determine changes in understanding of the pathogenesis of burn conversion, and subsequently examine the direction for future research in developing therapies. The majority of recent research focuses on applying therapies from other disease processes to common underlying pathogenic mechanisms in burn conversion. While ischemia, inflammation, and free oxygen radicals continue to demonstrate a critical role in secondary necrosis, novel mechanisms such as autophagy have also been shown to contribute affect significantly burn progression significantly. Further research will have to determine whether multiple mechanisms should be targeted when developing clinical therapies.

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First-aid with warm water delays burn progression and increases skin survival

Cited by 28 publications

References 34 publications

Hyperspectral Imaging for Burn Depth Assessment in an Animal Model

Hyperspectral Imaging for Burn Depth Assessment in an Animal Model

Med livet som innsats

Current concepts on burn wound conversion—A review of recent advances in understanding the secondary progressions of burns

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