Fipronil (Phenylpyrazole) induces hemato-biochemical, histological and genetic damage at low doses in common carp, Cyprinus carpio (Linnaeus, 1758)

Ghaffar, Abdul; Hussain, Riaz; Abbas, Ghulam; Kalim, Mujahid; Khan, Ahrar; Ferrando, Sara; Gallus, Lorenzo; Ahmed, Zulfiqar

doi:10.1007/s10646-018-1979-4

Cited by 37 publications

(28 citation statements)

References 42 publications

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“…Contamination with poisonous compounds such as pesticides, trace metal, heavy metals, polycyclic aromatic hydrocarbons and polycyclic aliphatic hydrocarbons and numerous other effluents causes varieties of adverse impacts on living organisms leading to considerable population damage. The development and advancement in technology, industries and common use of numerous synthetic and natural compounds have led to contamination of aquatic ecosystems (Ghaffar et al, 2015a;Ghaffar et al, 2016;Ghaffar et al, 2018a).…”

Section: Introductionmentioning

confidence: 99%

Dose and Time-Related Pathological and Genotoxic Studies on Thiamethoxam in Fresh Water Fish (Labeo rohita) in Pakistan

Ghaffar¹

2020

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Section: Introductionmentioning

confidence: 99%

Dose and Time-Related Pathological and Genotoxic Studies on Thiamethoxam in Fresh Water Fish (Labeo rohita) in Pakistan

Ghaffar¹

2020

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“…The pesticides and herbicides are extensively used in agriculture in response to increase demand of food due to growing population of the world. In spite of numerous benefits of these chemicals, their frequent and constant application has serious concerns to public health, marine and wildlife and the environment (Ghaffar et al, 2018a). Agriculture sector is the main and important source of variety of pesticides contaminations, those reach to adjacent water sources and their residues in different food crops lead to cause toxicological effects on exposed and non target species (Teixeira et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Hussain¹

2019

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Current experimental study was aimed to find out the clinico-hematological, serum biochemical and DNA damage impacts of commonly used herbicide (glyphosate) on non-target adult cockerels. Therefore, a total of 25 cockerels were randomly placed in wire cages in five different groups each containing five birds. After seven days of acclimatization, glyphosate-based herbicide was administered to cockerels of groups (B-E) @ 50, 75, 100 and 125 mg/kg BW respectively except group A (control) for 45 days. Blood and serum was collected at 15, 30 and 45 day of the trial from each cockerel. The treated birds at higher doses indicated different clinical signs such as ruffled feather, dullness, tremors, anemic wattle and comb, depression and reduced frequency of crowing. Feed consumption and body mass was significantly (P≤0.05) lowered in cockerels exposed to higher doses of herbicide. The hematological parameters including red blood cell counts, hematocrit and hemoglobin was significantly lower in treated cockerels. Results on different biochemical parameters showed significantly lower quantity of total proteins and albumin while significantly higher concentrations of liver function tests (alanine aminotransferase, aspartate aminotransferase, alkaline phosphate), kidney function tests (urea and creatinine), cardiac biomarkers (CK-Mb, triglycerides, cholesterol) and oxidative stress parameter (malondialdehyde) of treated cockerels in dose and time dependent manner. Results indicate that the frequency of cells with tail DNA was significantly (P≤0.001) in exposed cockerels. The findings of the study suggested that long term exposure of glyphosate induces adverse clinicohematological, serum biochemical and genotoxic effects on birds. A, 2019. Exposure to sub-acute concentrations of glyphosate induce clinicohematological, serum biochemical and genotoxic damage in adult cockerels. Pak Vet J, 39(2): 181-186. http://dx.

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“…Wepener et al (1992) determined that the presence of chromium in aquatic systems has the potential to decrease hematocrit levels (Wepener et al 1992). A similar response was seen with copper exposure , manganese exposure , arsenic exposure (Ghaffar et al 2016) and exposure to pesticides (Qureshi et al 2016;Ghaffar et al 2018). In these studies, as well as the present study, it is assumed that exposure to chemical pollutants (i.e.…”

Section: Discussionsupporting

confidence: 79%

“…Studies have shown that hematocrit levels have the potential to decrease in fish exposed to heavy metals as erythrocyte production is inhibited (Wepener et al 1992;Buthelezi et al 2000;. The same is true for fish exposed to synthetic chemicals commonly found in anthropogenically stressed landscapes (Ghaffar et al 2016(Ghaffar et al , 2018Qureshi et al 2016). For the first time, this study showed a decrease in the hematocrit levels of fishes residing in systems impacted by UOG.…”

Section: Introductionsupporting

confidence: 53%

“…In events that require the subject to consume more energy (i.e., avoiding predators), the red blood cell count increases and subsequently the hematocrit value increases (Marshall et al 2012). In stress events that involve exposure to heavy metals, pesticides and disease it is common to see a decrease in hematocrit as red blood cells are being destroyed and white blood cell counts are increasing Buthelezi et al 2000;Ghaffar et al 2018). We expect to see a decrease in the hematocrit levels of fish residing in UOG impacted stream as they are potentially subject to decreased water quality including heavy metal exposure.…”

Section: Hematocrit As a Proxy For Fish Healthmentioning

confidence: 99%

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Analysis of Unconventional Oil and Gas Impacts on Downstream Fish Assemblages and Physiological Stress

Ankeny¹

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Unconventional Oil and Gas (UOG) production has been steadily expanding throughout the mid-Atlantic since 2008. Increased sedimentation, degraded water chemistry and an overall decrease in habitat quality due to UOG is anticipated to negatively impact aquatic inhabitants, a common observation in other stressed landscapes (i.e., mining, agriculture, development). We assessed stream health through both community analysis and physiological parameters (i.e., growth and hematocrit). A before-after-control-impact study uncovered three fish metrics that were significantly different following UOG disturbances. The invertivore-piscivore metric decreased following UOG disturbance (p = 0.045) whereas two benthic metrics saw a surprising increase (p = 0.003 and p = 0.011). Further analysis revealed that fish communities are becoming more uniform as tolerant taxa proliferate through the chronically degraded systems. An ANCOVA alongside a linear mixed effect model failed to find a significant difference between the weight and length of Semotilus atromaculatus residing in both treatment conditions. S. atromaculatus were tested for hematological responses within eleven UOG impacted sites and eight reference sites with a linear mixed effect model. Hematocrit levels were found to be significantly lower in S. atromaculatus residing within UOG impacted streams (p = 0.029). A weak negative correlation (r =-0.397) suggests that as UOG well density increases, resident fish health decreases. Our findings indicate that in systems chronically impaired by anthropogenic stressors, physiological health indicators may provide better insight than community analyses. Additionally, we predict that the steady expansion of horizontal wells could lead to an overall degradation of resident fish populations as they exhibit degraded health. Our findings have potential to shape management practices and establish UOG protocols that protect aquatic environment. iii ACKNOWLEDGEMENTS I would like to begin by thanking my family for their never-ending support. My wife Chantelle Ankeny, for her motivation every day. She encouraged me to always work my hardest and she always showed interest in my project. I owe her immensely as she set aside her education to support me at graduate school. To our son, Griffin Ankeny, though he does not know it yet, I am motivated everyday by the thought of giving him a great life and providing for my family. My mother, Johnette Mathieson, for her belief in me. As a child, my mother instilled in me the urge to explore the outdoors and see the beauty that this world has to offer. She continuously encourages me to reach new heights. My father, Robert Kim Ankeny, for his encouragement. My father guided me through the Boy Scouts of America where he instilled in me countless life lessons as well as a passion for exploring the outdoors. Additionally, I would like to thank my fellow graduate students, especially Rebecca Long, Kevin Eliason and Brian Gordon. Kevin Eliason was always there when I needed him, be it running statistical ana...

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Fipronil (Phenylpyrazole) induces hemato-biochemical, histological and genetic damage at low doses in common carp, Cyprinus carpio (Linnaeus, 1758)

Cited by 37 publications

References 42 publications

Dose and Time-Related Pathological and Genotoxic Studies on Thiamethoxam in Fresh Water Fish (Labeo rohita) in Pakistan

Dose and Time-Related Pathological and Genotoxic Studies on Thiamethoxam in Fresh Water Fish (Labeo rohita) in Pakistan

Exposure to Sub-Acute Concentrations of Glyphosate Induce Clinico-Hematological, Serum Biochemical and Genotoxic Damage in Adult Cockerels

Analysis of Unconventional Oil and Gas Impacts on Downstream Fish Assemblages and Physiological Stress

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