Finite element simulation of infrared laser ablation for mass spectrometry

Huang, Fan; Murray, Kermit K.

doi:10.1002/rcm.6331

Cited by 4 publications

(1 citation statement)

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“…We interpret the production of nanoparticles and clusters of glycerol most efficiently at 2.9 μm as resulting from rapid boiling (phase explosion) when the laser is tuned to the OH stretch absorption maximum. [46] The phase explosion produces a large number of clusters and nanoparticles and relatively few coarse particles. This vigorous ejection of material on resonant absorption has been observed with fast photography using light scattering.…”

Section: Resultsmentioning

confidence: 99%

Particle formation by infrared laser ablation of MALDI matrix compounds

Musapelo

Murray

2014

J. Mass Spectrom.

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The concentration and size distribution of particles ablated from the infrared matrix-assisted laser desorption/ionization matrix compounds succinic acid (butanedioic acid), α-cyano-4-hydroxycinnamic acid, and glycerol were measured using an aerodynamic particle sizer combined with a scanning mobility particle sizer. The two sizing instruments together had a sizing range to from 10 nm to 20 µm. Thin layers of the matrix compounds were irradiated with fluences between 6.0 and 9.5 kJ/m(2) and wavelengths between 2.8 and 3.0 µm. The distribution of particles was characterized by a large concentration of clusters in the 20-nm-diameter range and large component of mass in the range of coarse particle with diameters greater than 1 µm. The wavelength dependence revealed a blue shift for the maximum particle production that is attributed to heating and disruption of the hydrogen bonds in the matrix that shifts the absorption to shorter wavelengths. This blue shift has been observed previously in infrared matrix-assisted laser desorption/ionization.

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Section: Resultsmentioning

confidence: 99%

Particle formation by infrared laser ablation of MALDI matrix compounds

Musapelo

Murray

2014

J. Mass Spectrom.

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Particle Production in Reflection and Transmission Mode Laser Ablation: Implications for Laserspray Ionization

Musapelo

Murray

2013

J. Am. Soc. Mass Spectrom.

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Particles were ablated from laser desorption and inlet ionization matrix thin films with a UV laser in reflection and transmission geometries. Particle size distributions were measured with a combined scanning mobility particle sizer (SMPS) and aerodynamic particle sizer (APS) system that measured particles in the size range from 10 nm to 20 μm. The matrixes investigated were 2,5-dihydroxybenzoic acid (DHB), α-cyano-4-hydroxycinnamic acid (CHCA), sinapic acid (SA), 2,5-dihydroxy-acetophenone (DHAP), and 2-nitrophloroglucinol (NPG). Nanoparticles with average diameters between 20 and 120 nm were observed in both transmission and reflection geometry. The particle mass distribution was significantly different in reflection and transmission geometry. In reflection geometry, approximately equal mass was distributed between particles in the 20 to 450 nm range of diameters and particles in the 450 nm to 1.5 μm diameter range. In transmission mode, the particle mass distribution was dominated by large particles in the 2 to 20 μm diameter range. Ablation of inlet ionization matrices DHAP and NPG produced particles that were 3 to 4 times smaller compared with the other matrices. The results are consistent with ion formation by nanoparticle melting and breakup or melting and breakup of the large particles through contact with heated inlet surfaces. ᅟ

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Three dimensional transient behavior of thin films surface under pulsed laser excitation

Dimitriou

Kaselouris

Orphanos

et al. 2013

Applied Physics Letters

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The three dimensional spatiotemporal response of thin metal films surfaces excited by nanosecond laser pulses is investigated in both the thermoelastic and the ablation regimes. An experimental laser whole-field interferometric technique allows for the direct monitoring of the dynamic deformation of a macroscopic area on the surface with ultrahigh lateral resolution. A specially developed three dimension finite element model simulates the laser-surface interaction, predicts the experimentally obtained results, and computes key parameters of matter's thermomechanical response. This method provides a powerful instrument for spatiotemporal behavior of thin-film surfaces under extreme conditions demanded for innovative applications.

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Finite element simulation of infrared laser ablation for mass spectrometry

Abstract: These results suggest that the best performance for pulsed IR laser sample irradiation is in the wavelength range from 2.9 to 3.1 µm for materials with a strong OH stretch absorption.

Cited by 4 publications

References 46 publications

Particle formation by infrared laser ablation of MALDI matrix compounds

Particle formation by infrared laser ablation of MALDI matrix compounds

Particle Production in Reflection and Transmission Mode Laser Ablation: Implications for Laserspray Ionization

Three dimensional transient behavior of thin films surface under pulsed laser excitation

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