Finite Element Modeling of Mitral Valve Dynamic Deformation Using Patient-Specific Multi-Slices Computed Tomography Scans

Abstract

The objective of this study was to develop a patient-specific finite element (FE) model of a human mitral valve. The geometry of the mitral valve was reconstructed from multi-slice computed tomography (MSCT) scans at middle diastole with distinguishable mitral leaflet thickness, chordal origins, chordal insertion points, and papillary muscle locations. Mitral annulus and papillary muscle dynamic motions were also quantified from MSCT scans and prescribed as boundary conditions for the FE simulation. Material properties of the human mitral leaflet tissues were obtained from biaxial tests and characterized by an anisotropic hyperelastic material model. In vivo dynamic closing of the mitral valve was simulated. The closed shape of the mitral valve output from the simulation was similar to the mitral valve geometry reconstructed from MSCT images at middle systole. Forces from the anterolateral and posteromedial papillary muscle groups at middle systole were 4.51 N and 5.17 N, respectively. The average maximum principal stress of the midsection of the anterior mitral leaflet was approximately 160 kPa at the systolic peak. Results demonstrated that the developed FE model could closely replicate in vivo mitral valve dynamic motion during middle diastole and systole. This model may serve as a basis for utilizing computational simulations to obtain a better understanding of mitral valve mechanics, disease and surgical repair.

Fluid-Structure Interaction Model of Human Mitral Valve within Left Ventricle

“…Those differences suggest that the incorporation of the left ventricle (the valvular-ventricle interaction) is necessary for modelling the flow patterns around the MV. However, if one is only interested in the MV closure, then a reduced-model (MV only) may be sufficient [6,17]. During diastole, the MV-LV model seems to produce a smaller orifice compared to the corresponding MV-tube model.…”

“…Recent development involves finite strain deformational kinematics, realistic anatomical geometries and advanced hyperelastic constitutive models [2,16,17]. However, most of the studies are based on purely structural analysis with applications to a statically or dynamically pressurized closed valve in isolated situation [9].…”

A D-Shaped Bileaflet Bioprosthesis Which Replicates Physiological Left Ventricular Flow Patterns1

“…al. [18], consisting of one smaller posterior leaflet and a larger anterior leaflet (Fig 1). Upon fixation in glutaraldehyde, the pericardium was sutured onto a D-shaped stent fabricated by a 3D Objet260 printer (Stratasys, Eden Prairie, MN).…”

Multi-modal Pipeline for Comprehensive Validation of Mitral Valve Geometry and Functional Computational Models

“…Driven by the growing prevalence of MV diseases, researchers are developing methods to assess MV anatomy from multiple imaging modalities and simulate its physiology using biomechanical models [3,4]. However, the clinical applicability is limited as they either do not enable patient-specific personalization of the geometric model or this process requires tedious manual interactions.…”