Fingerroot (Boesenbergia pandurata) Extract Inhibits the Accumulation of Visceral Fat in C57BL/6J Mice

Abstract

Boesenbergia pandurata (Roxb.) Schltr. has been reported to possess anti-oxidative and anti-inflammatory properties. The aim of this study was to investigate the effect of Boesenbergia pandurata extract (BPE) in a high-fat diet (HFD)-induced obese mice model. C57BL/6J mice were fed with either the high-fat diet or a 0.5% BPE-supplemented HFD for 8 weeks. The BPE-containing HFD significantly reduced body weight gain and the accumulation of visceral fat mass in mice model without altering the amount of food intake. Moreover, mice fed with BPE-containing HFD had lower concentrations of lipids in their blood, lower hepatic lipid accumulation, and lower serum leptin levels compared with the HFD-fed mice. RT-PCR analysis showed that the expression levels of peroxisome proliferators-activated receptor γ2 (PPARγ2) and CCAT/enhancer binding protein α (C/EBPα) genes in the epididymal fat tissue of mice fed the BPE-containing HFD increased 1.16-and 1.30-fold, respectively, compared to mice fed HFD only. In conclusion, BPE attenuated visceral fat accumulation and improved dyslipidemia in a mice model with HFD-induced obesity.Key

Pinostrobin: An Adipogenic Suppressor from Fingerroot (Boesenbergia rotunda) and Its Possible Mechanisms

“…Interestingly, several dietary supplements for weight loss in the market indicate fingerroot as the main active ingredient [29]. Studies on high-fat-diet mice indicated that fingerroot extracts prepared from the materials collected from Indonesia could reduce body weight gain by decreasing the accumulation of visceral fat [26,30,31]. Pandurantin A was found to be the major component (0.8% w/w based on dried weight) and was shown to suppress adipogenesis in mouse pre-adipocytes via regulating AMP-activated protein kinase (AMPK) and PPARα/δ signals [26].…”

Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

“…Numerous reports have indicated fingerroot extract’s anti-adipogenic and anti-obesity properties over the past decade. Mechanisms such as activated protein kinase, regulation of lipid metabolism, reduced triglyceride, and increased HDLC4 were identified in rodent models with high-fat diets [46] , [47] , [48] . This toxicity study provides valuable insights and directs the future research of the fingerroot extract formulation.…”