Oral sub-chronic toxicity of fingerroot (Boesenbergia rotunda) rhizome extract formulation in Wistar rats

Oral Bioavailability, Tissue Distribution, Metabolism, and Excretion of Panduratin A from Boesenbergia rotunda Extract in Healthy Rats

“…Our previous sub-chronic toxicity study showed that the administration of 25–100 mg/kg/day of fingerroot extract formulation in rats for 90 days showed no evidence of toxicity or mortality. 22 Therefore, a dose of 45 mg/kg/day of panduratin A-consisted fingerroot extract was administered to examine absolute oral bioavailability, tissue distribution, metabolism, and excretion recovery in rats. In our previous study, healthy dogs were injected with 1 mg/kg/day of pure panduratin A and fed with 5 and 10 mg/kg/day of panduratin A-consisted fingerroot extract formulation that showed acceptable pharmacokinetic parameters and possible metabolic pathways.…”